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| 2. |
- Monti, M., et al.
(författare)
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Microcalorimetric investigation of cell metabolism in tumour cells from patients with non‐Hodgkin lymphoma (NHL)
- 1986
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Ingår i: Scandinavian Journal of Haematology. - : Wiley. - 0036-553X. ; 36:4, s. 353-357
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Tidskriftsartikel (refereegranskat)abstract
- The overall metabolism in tumour cells from 36 untreated patients with non‐Hodgkin lymphoma was evaluated by direct calorimetry. For 20 patients with lymphoma of high grade malignancy the median value of heat production rate per tumour cell was 3.9 pW and for 16 patients with low grade lymphomas the corresponding value was 2.8 pW. The difference between the two morphclogical groups is significant (p = 0.05). The median value of heat production rate per tumour cell from 13 patients who died within 2 yr after diagnosis was 4.0 pW. The corresponding value for 17 patients who have survived for more than 2 yr was 2.5 pW. The difference between the two groups is significant (p = 0.02). A high correlation was found between heat production rates in tumour cells and survival of the patients (p = 0.006).
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| 3. |
- Olsson, H., et al.
(författare)
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Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents
- 1988
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 14:4, s. 246-251
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Tidskriftsartikel (refereegranskat)abstract
- An occupational history of exposure to organic solvents, defined as daily occupational exposure for at least one year, was more common among 167 men with newly diagnosed non-Hodgkin's lymphoma than among 130 healthy referents from the general population (38 versus 14%). Categorization in five-year age groups gave 3.3 as a Mantel-Haenszel estimate of the odds ratio (95% CI 1.9-5.8). The odds ratio was 6.5 (95% CI 3.2-13.3) for localized supradiaphragmatic tumors and 2.3 (95% CI 1.3-4.3) for other lymphoma presentations. In a logistic model including age and organic solvent, phenoxy acid, and chlorophenol exposure, it could be shown that solvent exposure was an independent risk factor and that no important interaction occurred between the risk factors. With increasing duration of exposure there was a significantly increased risk of lymphoma, a finding implying a dose-response relationship. There was no significant difference in tumor histology between the exposed and unexposed patients. These findings support the concept that occupational exposure to organic solvents is a risk factor for non-Hodgkin's lymphoma. The results also confirm a strong association between such exposure and an supradiaphragmatic location of the lymphomas.
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| 4. |
- Åkerman, M., et al.
(författare)
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Mitotic activity in non-Hodgkinʹs lymphoma. Relation to the kiel classification and to prognosis
- 1987
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 55:2, s. 219-223
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Tidskriftsartikel (refereegranskat)abstract
- At histopathological diagnosis of non-Hodgkin's lymphoma (NHL) the mean number of mitoses in 10 high power fields (×40) was determined in thin sections (2μm) and designated 'mitotic index' (MI). In 38 patients the thymidine labelling index (LI) of the lymphoma cells was also determined. There was a close correlation between MIs and LIs (r=0.81, P<0.001) indicating that MI reflects the proliferative activity in NHL. Among 101 patients with NHL classified according to the Kiel nomenclature MIs were generally lower in lymphomas of low grade malignant type than in the high grade malignant lymphomas. The variation of MIs within morphological subgroups was especially pronounced in high grade lymphomas. Only 18 of 49 patients (37%) with MI ≧ 2 have survived for 2 years in contrast to 37 of 52 patients (77%) with MI<2 (P=0.001). For patients with histologically low grade lymphomas and MI ≧ 2.0 the median survival was 23 months and for those with MI<2.0 58 months (P=0.09). Patients with high grade lymphomas and MI ≧ 2.0 had a median survival of 15 months compared to 57 months for those with MI <2.0 (P= 0.04). In a multivariate analysis of 50 patients with centroblastic-centrocytic (CB-CC) or centroblastic (CB) lymphomas the importance of different prognostic factors was analysed. Among the variables age, MI, growth pattern (follicular vs. diffuse), cell type (CB-CC vs. CB), clinical stage (I vs. II-IV), initial chemotherapy (active vs. less active) only age and MI gave significant prognostic information. It is concluded that the assessment of mitoses in NHL gives prognostic information in addition to histopathologic classification. The method is simple and the proliferative activity and histopathological diagnosis can be ascertained routinely on the same occasion.
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