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- Brant, William R., et al.
(författare)
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Rapid Lithium Insertion and Location of Mobile Lithium in the Defect Perovskite Li0.18Sr0.66Ti0.5Nb0.5O3
- 2012
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Ingår i: ChemPhysChem. - : Wiley-Blackwell. - 1439-4235 .- 1439-7641. ; 13:9, s. 2293-2296
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Tidskriftsartikel (refereegranskat)abstract
- Fast and fancy: Lithium that was originally disordered within the structure of the perovskite Li0.18Sr0.66Ti0.5Nb0.5O3 can be induced into ordering within the yellow region of the unit cell by low temperatures and treatment with n-butyl-lithium. The fast kinetics of lithium insertion, in connection with a color change, make this nontoxic, air-stable material a suitable candidate for use in electrochromic systems or lithium-storage batteries.
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| 4. |
- Franke, Andre, et al.
(författare)
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
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Tidskriftsartikel (refereegranskat)abstract
- We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
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| 5. |
- Stark, Daniel P., et al.
(författare)
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Ultraviolet emission lines in young low-mass galaxies at z similar or equal to 2 : physical properties and implications for studies at z > 7
- 2014
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 445:3, s. 3200-3220
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Tidskriftsartikel (refereegranskat)abstract
- We present deep spectroscopy of 17 very low mass (M* similar or equal to 2.0 x 10(6)-1.4 x 10(9) M-circle dot) and low luminosity (M-UV similar or equal to -13.7 to -19.9) gravitationally lensed galaxies in the redshift range z similar or equal to 1.5-3.0. Deep rest-frame ultraviolet spectra reveal large equivalent width emission from numerous emission lines (N IV], O III], C IV, Si III], C III]) which are rarely seen in individual spectra of more massive star-forming galaxies. C III] is detected in 16 of 17 low-mass star-forming systems with rest-frame equivalent widths as large as 13.5 angstrom. Nebular C (IV) emission is present in the most extreme C III] emitters, requiring an ionizing source capable of producing a substantial component of photons with energies in excess of 47.9 eV. Photoionization models support a picture whereby the large equivalent widths are driven by the increased electron temperature and enhanced ionizing output arising from metal-poor gas and stars (0.04-0.13 Z(circle dot)), young stellar populations (6-50 Myr), and large ionization parameters (log U = -2.16 to -1.84). The young ages implied by the emission lines and continuum spectral energy distributions (SEDs) indicate that the extreme line emitters in our sample are in the midst of a significant upturn in their star formation activity. The low stellar masses, blue UV colours, and large specific star formation rates of our sample are similar to those of typical z greater than or similar to 6 galaxies. Given the strong attenuation of Ly alpha in z greater than or similar to 6 galaxies, we suggest that C III] is likely to provide our best probe of early star-forming galaxies with ground-based spectrographs and one off the most efficient means of confirming z greater than or similar to 10 galaxies with the James Webb Space Telescope.
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| 6. |
- Vehik, Kendra, et al.
(författare)
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Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY
- 2013
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Ingår i: Diabetes/Metabolism Research & Reviews. - : Wiley. - 1520-7552. ; 29:7, s. 557-567
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe vast array and quantity of longitudinal samples collected in The Environmental Determinants of Diabetes in the Young study present a series of challenges in terms of quality control procedures and data validity. To address this, pilot studies have been conducted to standardize and enhance both biospecimen collection and sample obtainment in terms of autoantibody collection, stool sample preservation, RNA, biomarker stability, metabolic biomarkers and T-cell viability. Research Design and MethodsThe Environmental Determinants of Diabetes in the Young is a multicentre, international prospective study (n=8677) designed to identify environmental triggers of type 1 diabetes (T1D) in genetically at-risk children from ages 3months until 15years. The study is conducted through six primary clinical centres located in four countries. ResultsAs of May 2012, over three million biological samples and 250 million total data points have been collected, which will be analysed to assess autoimmunity status, presence of inflammatory biomarkers, genetic factors, exposure to infectious agents, dietary biomarkers and other potentially important environmental exposures in relation to autoimmunity and progression to T1D. ConclusionsDetailed procedures were utilized to standardize both data harmonization and management when handling a large quantity of longitudinal samples obtained from multiple locations. In addition, a description of the available specimens is provided that serve as an invaluable repository for the elucidation of determinants in T1D focusing on autoantibody concordance and harmonization, transglutaminase autoantibody, inflammatory biomarkers (T-cells), genetic proficiency testing, RNA lab internal quality control testing, infectious agents (monitoring cross-contamination, virus preservation and nasal swab collection validity) and HbA(1c) testing. Copyright (c) 2013 John Wiley & Sons, Ltd.
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