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Salivary IgA respon...
Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri
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- Ericson, Dan (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Hamberg, Kristina (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Bratthall, Gunilla (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Sinkiewicz-Enggren, Gabriela (author)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)
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- Ljunggren, Lennart (author)
- Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV)
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(creator_code:org_t)
- Wiley-Blackwell, 2013
- 2013
- English.
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In: Pathogens and Disease. - : Wiley-Blackwell. - 2049-632X. ; 68:3, s. 82-87
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti-mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice daily chewing of gum containing Lactobacillus reuteri (2 9 108 CFU per dose) and the control group (n = 12) received placebo. Resting saliva was collected before and after 12 weeks of treatment and 4 weeks after end of treatment. Total salivary IgA concentrations were measured by ELISA. Specific IgA reactivity was determined using a whole-cell ELISA. Results were expressed as % IgA per protein in saliva. The level of total IgA% per protein increased significantly between pretreatment levels (13.5%) and follow-up treatment levels (14.4%) within the test group only (P < 0.05). No changes were seen in the control group during the trial. The level of probiotic-reactive antibodies decreased significantly between pre- and post-treatment samples (from 12.2% to 9.0%, P < 0.05) in the test group. Similarly, the level of specific mutans streptococci antibodies decreased significantly between pre- and post-treatment samples (P < 0.05) in the test group only (for Streptococcus mutans from 20.1% to 15.0%; for Streptococcus sobrinus from 7.4% to 5.3%). Ingestion of probiotic bacteria might influence the adaptive immune response of the host.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- probiotics
- salivary IgA
- mutans streptococci
- Lactobacillus reuteri
Publication and Content Type
- ref (subject category)
- art (subject category)
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