| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- Bokan, Petar
(författare)
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Pair production of Higgs bosons in the final state with bottom quarks and τ leptons in the ATLAS experiment : Search results using LHC Run 2 data and prospect studies at the HL-LHC
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- After the discovery of the Higgs boson, the ultimate test of the electroweak symmetry breaking and the Standard Model (SM) of particle physics is to establish evidence of Higgs boson self-coupling, which can be achieved by searching for pair production of Higgs bosons. In addition, many theories beyond the SM predict heavy resonances that could decay into pairs of Higgs bosons. A search for non-resonant and resonant pair production of Higgs bosons in the final state with two bottom quarks and two τ leptons (bb̄τ+ τ−) is presented for 36.1 fb-1 of proton-proton collision data at a centre-of-mass energy of 13 TeV recorded by the ATLAS experiment at the Large Hadron Collider (LHC). The observed (expected) 95% confidence level (CL) upper limit on the non-resonant Higgs boson pair production cross-section times the bb̄τ+τ- branching ratio corresponds to 12.7 (14.8) times the SM prediction. The ratio of the Higgs boson self-coupling to its SM expectation, κλ, is observed (expected) to be constrained to κλ ∈ [-7.4, 15.7] ([-8.9, 16.8]) at 95% CL. The sensitivity is extrapolated to a 14 TeV centre-of-mass energy and 3000 fb-1, which is the target integrated luminosity of the High-Luminosity LHC (HL-LHC). Various extrapolation assumptions are taken into account. The estimated expected signal significance for the SM Higgs boson pair production in the bb̄τ+τ- final state at the HL-LHC reaches 2.1 standard deviations, while the expected allowed κλ interval is κλ ∈ [-0.8, 8.8] at 95% CL, assuming the SM Higgs boson couplings. Furthermore, potential improvements of the analysis techniques are discussed in the context of searches for pair production of Higgs bosons with the full Run 2 ATLAS data.
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| 4. |
- Coignard, J, et al.
(författare)
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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- 2021
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 1078-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10−8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
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