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- Burney, P., et al.
(författare)
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A case-control study of the relation between plasma selenium and asthma in European populations : a GAL2EN project
- 2008
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 63:7, s. 865-871
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma. METHODS: The GA(2)LEN network has organized a multicentre case-control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months. RESULTS: All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 microg/l in Palermo to 67.7 microg/l in Vienna and 56.1 microg/l among the children in Oslo. Random effects meta-analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 microg/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89-1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29-0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98-2.90) and Ghent (OR: 1.35; 95% CI: 1.03-1.77). CONCLUSION: This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.
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| 4. |
- Ericson, Dan, et al.
(författare)
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Clinical evaluation of two minimal interventional restorative approaches : 5-year follow-up
- 2007
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Konferensbidrag (refereegranskat)abstract
- Objective: To compare the performance of two minimally invasive restorative treatment approaches for managing dental caries. Methods: A total of 50 pregnant women (second trimester of pregnancy), mean age 22±5.30 years, were treated by two previously trained operators. The treatment approaches tested were: chemo-mechanical (Carisolv-MediTeam, Sweden) and mechanical (Atraumatic Restorative Treatment -ART) methods. A parallel-group study design was used in which the two treatments were randomly placed in 50 matched pairs of permanent teeth. The treatments were performed in Public Health Centers located in suburban areas of Bauru city in Brazil. The restorative material used was high strength glass ionomer cement (Ketac Molar, 3M ESPE).The restorations were evaluated by 2 calibrated independent double-blind examiners according to ART criteria. The inter examiner kappa was 0.93. The data were analyzed using 95% confidence interval on the binomial distribution and Fisher Exact test. A difference was statistically significant if p<0.05. Results: In a 5-year follow-up, 34% of the restorations were evaluated. In the chemo-mechanical group 53% (CI=27-77%) of the restorations were considered as successful and in the mechanical group 60% (CI=33-83%). There was no statistically significant difference between the 5-year success rate for both groups (p=0.73). Conclusion: The two minimal interventional restorative approaches showed similar clinical performance after 5 years.
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