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- Rylander, L, et al.
(författare)
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Per- and Polyfluoroalkyl Substances in Early Pregnancy and Risk for Preeclampsia: A Case-Control Study in Southern Sweden
- 2020
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Ingår i: Toxics. - : MDPI AG. - 2305-6304. ; 8:2
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Tidskriftsartikel (refereegranskat)abstract
- Preeclampsia is one of the most common causes of perinatal and maternal morbidity/mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per- and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk of developing preeclampsia. The study included 296 women diagnosed with preeclampsia (cases) and 580 healthy pregnant women (controls). Maternal serum samples were obtained from a biobank of samples collected in early pregnancy in connection with screening for infections. Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) were analyzed using liquid chromatography-tandem-mass-spectrometry (LC/MS/MS). Among primiparous women, there were no differences in PFAS concentrations in early pregnancy between the cases and the controls whereas among multipara women, the cases had significantly higher concentrations of PFNA (median concentrations were 0.44 and 0.38 ng/mL, p = 0.04). When individual PFAS were categorized into quartiles and adjustment for potential confounders was performed, the women in the highest quartiles had no significant increased risks of developing preeclampsia as compared with women in the lowest category. In conclusion, the present study provides limited support for the hypothesized association between PFAS and preeclampsia in a population with relatively low exposure levels.
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- Broberg, K., et al.
(författare)
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OS03-11 Exposure to PFAS and associated toxicity in workers exposed to hexavalent chromium – a cross-sectional study within the SafeChrom project : Abstracts of the 58th Congress of the European Societies of Toxicology (EUROTOX 2024)
- 2024
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Ingår i: Toxicology Letters. - 0378-4274. ; 399:Supplement 2, s. 67-67
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundThis study aimed to investigate the exposure to perfluoroalkyl substances (PFAS) and cancer-related toxicity in workers in different Swedish industry sectors with exposures to hexavalent chromium (Cr(VI)).MethodsThe study consisted of 111 exposed workers and 72 controls. The exposed workers were performing manufacture/processing of metal products (n=55), working in steel production (n=31), bath plating (n=17), a nd o thers (n=8). T he P FAS e xposure w as a ssessed b y t he determination of ten PFAS in serum samples by LC-MS/MS. Cr was measured in red blood cells (RBC) by ICP-MS, as a long-term marker for Cr(VI) exposure. Telomere length and DNA methylation of lung cancer-related genes in DNA from peripheral blood were measured by qPCR and pyrosequencing, respectively.ResultsSignificant differences between workers with Cr(VI) exposure and controls were found for the PFHpA and PFOA (P<0.001, linear regression analysis adjusted for age). There were significant differences between occupational groups where the bath platers showed significantly higher levels of PFHpA, PFHPS, PFPeS, PFOS, PFDS, and PFHxS compared with the other occupational groups. The highest serum concentration was found for PFOS: 700 ng/ml in a bath plater, to be compared with the median concentration of 3.82 ng/ml among the controls. PFOA and PFHPS correlated positively with RBC-Cr (rS=0.27 and 0.35 respectively) in exposed workers. PFOA was associated with shorter telomere length after adjustment for age. No clear associations was found for DNA methylation in cancer-related genes. Ongoing analysis will assess mixture effects on toxicity biomarkers.ConclusionThe considerably high PFAS exposure in Cr(VI) bath platers can be explained by the former application of PFAS as mist suppressants in electroplating baths but further sources of exposure should be examined. The association between PFAS and some cancer-related biomarkers warrants further examination, including potential mixture effects.
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