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Träfflista för sökning "WFRF:(Brodeur J.) srt2:(2005-2009)"

Search: WFRF:(Brodeur J.) > (2005-2009)

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  • Saxena, Richa, et al. (author)
  • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
  • 2007
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
  • Journal article (peer-reviewed)abstract
    • New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
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3.
  • Crawley, E. F., et al. (author)
  • Overview
  • 2007
  • In: Rethinking Engineering Education. - Boston, MA : Springer-Verlag New York. - 9780387382876 ; , s. 6-44
  • Book chapter (peer-reviewed)abstract
    • The objective of engineering education is to educate students who are ready to engineer, that is, broadly prepared with the pre-professional skills of engineering, and deeply knowledgeable of the technical fundamentals. It is the task of engineering educators to continuously improve the quality and nature of undergraduate engineering education in order to meet this objective. Over the past 25 years, many in industry, government, and university programs have addressed the need for reform of engineering education, often by stating the desired outcomes in terms of attributes of engineering graduates. By examining these views, we identified an underlying need: to educate students to understand how to Conceive-Design-Implement-Operate complex value-added engineering products, processes and systems in a modern, team-based environment.
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