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| 2. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 3. |
- Hashemi, Nashmil, et al.
(författare)
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Right ventricular mechanics and contractility after aortic valve replacement surgery : a randomised study comparing minimally invasive versus conventional approach
- 2018
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Ingår i: Open heart. - : BMJ Publishing Group Ltd. - 2053-3624. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- Objective Minimally invasive aortic valve replacementsurgery (MIAVR) is an alternative surgical technique to conventional aortic valve replacement surgery (AVR) in selected patients. The randomised study Cardiac Function after Minimally Invasive Aortic Valve Implantation (CMILE) showed that right ventricular (RV) longitudinal function was reduced after both MIAVR and AVR, but the reduction was more pronounced following AVR. However, postoperative global RV function was equally impaired in both groups. The purpose of this study was to explore alterations in RV mechanics and contractility following MIAVR as compared with AVR. Methods A predefined post hoc analysis of CMILE consisting of 40 patients with severe aortic valve stenosis who were eligible for isolated surgical aortic valve replacement were randomised to MIAVR or AVR. RV function was assessed by echocardiography prior to surgery and 40 days post-surgery. Results Comparing preoperative to postoperative values, RV longitudinal strain rate was preserved following MIAVR (-1.5 +/- 0.5 vs -1.5 +/- 0.4 1/s, p=0.84) but declined following AVR (-1.7 +/- 0.3 vs -1.4 +/- 0.3 its, p<0.01). RV longitudinal strain reduced following AVR (-27.4 +/- 2.9% vs -18.8%+/- 4.7%, p<0.001) and MIAVR (-26.5 +/- 5.3% vs -20.7%+/- 4.5%, p<0.01). Peak systolic velocity of the lateral tricuspid annulus reduced by 36.6% in the AVR group (9.3 +/- 2.1 vs 5.9 +/- 1.5 cm/s, p<0.01) and 18.8% in the MIAVR group (10.1 +/- 2.9 vs 8.2 +/- 1.4 cm/s, p<0.01) when comparing preoperative values with postoperative values. Conclusions RV contractility was preserved following MIAVR but was deteriorated following AVR. RV longitudinal function reduced substantially following AVR. A decline in RV longitudinal function was also observed following MIAVR, however, to a much lesser extent.
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| 4. |
- Järver, Peter, et al.
(författare)
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Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
- 2018
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathways used by cargo destined for TLR3/4/7 signaling endosomes. Both ssDNA and ssRNA conferred the endocytic inhibition, it was concentration dependent, and required a certain ssON length. The ssON-mediated inhibition modulated signaling downstream ofTLRs that localized within the affected endosomal pathway. We further show that injection of ssON dampens dsRNA-mediated inflammatory responses in the skin of non-human primates. These studies reveal a regulatory role for extracellular ssON in the endocytic uptake of TLR ligands and provide a mechanistic explanation of their immunomodulation. The identified ssON-mediated interference of endocytosis (SOMIE) is a regulatory process that temporarily dampens TLR3/4/7 signaling, thereby averting excessive immune responses.
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| 5. |
- Navarro, Priscilla, 1989-
(författare)
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Exploring Process Management as a Means for Greening Road Freight Transport
- 2019
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Research has proven that we need to reduce our environmental impact. Sweden has set a goal to become fossil free by 2045. The increasing amount of transport and the need to reduce its environmental effects has put pressure on the companies of the road freight transport sector. Therefore, this business sector needs research actions to find tools that will assist in the greening of its services and operations. My research is a contribution to these efforts from a managerial point of view.Process management is a methodology taken from Total Quality Management (TQM) that has been used in several business sectors to improve business performance. Its process orientation and focus on customers allow companies to identify and satisfy the current and latent needs of their customers. Until now, TQM has targeted customer needs. However, it is experiencing a shift towards incorporating societal needs into the equation. Environmental sustainability is becoming a societal requirement for companies in all sectors. Hence, the purpose of my research is to explore the possibilities of using process management to support the greening of small and medium-sized companies within the road freight transport sector.The frame of reference for my study is based on three well-established domains in academia and their intersections. These domains are: process management, road freight transport and environmental sustainability. I have used qualitative methods for my research. Specifically, I performed a case study at two medium-sized Swedish companies within the road freight transport business sector. The data collection methods involved document studies, observations and interviews at each case company. The case study was performed using an action research approach, which involved setting up meetings, seminars and workshops with each case company. Additionally, joint workshops were performed, which allowed me to observe and obtain results from the interactions between the companies. The analysis is presented for each case separately and then for their interactions. The results are compared with the existing literature from the three domains.I based my research on three research questions. The first was intended to identify the principles and tools within process management that may be applied to road freight transport companies interested in implementing this methodology to enhance their environmental sustainability. I concluded that these principles were present in the companies and are needed for the implementation of process management. The tools included in this methodology can be associated with environmental initiatives performed by the companies in support of their greening.The second research question refers to the benefits and challenges that companies in this business sector may face when implementing process management methodology. I conclude that most of the expected benefits of process management were confirmed. Additionally, a new benefit was observed: reducing the environmental effect of their services can interest current customers and attract new customers to road freight transport companies. The challenges identified during the case study include: resistance to change, lack of knowledge and resource allocation limitations. I also confirmed that a stepwise implementation of process management increases the likelihood of the success of the methodology. Hence, underdeveloped management systems are also a challenge when this methodology is used in freight transport companies.The third and final research question involves the adaptations required for process management to enhance environmental sustainability in companies in this business sector. I refer to each of the challenges found and suggest certain requirements for the companies to apply this methodology. Clear communication from top management, the training of employees and the involvement of all employees are some of these requirements. Moreover, to incorporate the environmental aspects clearly, I suggest environmental efforts for each step in the implementation of process management. By including these efforts in the process maturity model, I conclude that road freight transport companies could use process management as a means of enhancing environmental sustainability.
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| 6. |
- Navarro, Priscilla, 1989-, et al.
(författare)
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Greening logistics by introducing process management : A viable tool for freight transport companies going green
- 2018
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Ingår i: Supply Chain Forum. - : Taylor & Francis. - 1625-8312 .- 1624-6039. ; 19:3, s. 204-218
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Tidskriftsartikel (refereegranskat)abstract
- While the usage of process management within the freight transport industry is unknown and presumed low, it has been used within other sectors as an efficient approach for dealing with and fulfilling customer demands as well as environmental requirements. The purpose of this paper is to investigate how process management can enhance a customer focused greening in the transport and logistics sector. We present a literature review of the intersections of process management, freight transport and environmental sustainability. Furthermore, we conducted a case study of how two environmentally ambitious Swedish freight transport companies use process management to enhance environmental sustainability. We found that environmentally ambitious freight transport companies do not proactively use process management, and that workshops with topical experts and practitioners can be a way for introducing process management to enhance environmental sustainability in such companies.
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| 7. |
- Navarro, Priscilla, 1989-, et al.
(författare)
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Using Process Management within Green Logistics – A case study
- 2017
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- PurposeWhile Process Management has not commonly been used within the freight transport business, it has been used within other sectors as an efficient approach for dealing with and fulfilling customer demands as well as environmental requirements. The purpose of the current paper is to present a case study of how Swedish freight transport companies use Process Management to enhance environmental sustainability.Methodology/ApproachWe developed a case study with two environmentally ambitious Swedish freight transport companies. Information was collected by interviews, observations and workshops. We also studied three larger freight transport companies. The analysis is a comparison between empirical findings and literature.FindingsEnvironmentally ambitious freight transport companies do not proactively use Process Management, and workshops with topical experts and practitioners can be a way for introducing Process Management to enhance environmental sustainability in such companies.Research Limitation/implicationThe results will be the basis for propositions for further research, and for practical implications for transport companies.Originality/Value of the paperA previous study of the intersection between Process Management and Green Logistics identified a void in literature, which makes this paper unique. Academically, this paper contributes to filling that void. Practically, the paper is useful for freight transport practitioners with interest in increasing sustainability in their operations.
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| 8. |
- Navarro, Priscilla, 1989-, et al.
(författare)
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What is the potential of process management to enhance sustainability in the freight transport sector?
- 2017
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The freight transport sector largely contributes to the environmental footprint, and the freight transport industry lacks practical tools for implementing green initiatives. Process Management is an efficient approach for fulfilling customer demands as well as environmental requirements within other sectors. This paper presents a literature review of Process Management activities within the freight transport sector, with emphasis on environmental sustainability. While Green Logistics and Process Management are established academic research disciplines, there is little research found in the intersection between the two. Hence, there is a need for future research in this field.
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| 9. |
- Ran, C., et al.
(författare)
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Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden
- 2016
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 45
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Tidskriftsartikel (refereegranskat)abstract
- Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohort reported to date; 1625 cases and 2025 control individuals. We found a significant association with high effect size of the rare variant L444P with PD (odds ratio 8.17; 95% confidence interval: 2.51-26.23; p-value = 0.0020) and a significant association of the common variant E326K (odds ratio 1.60; 95% confidence interval: 1.16-2.22; p-value = 0.026). The rare variant N370S showed a trend for association. Most L444P carriers (68%) were found to reside in northern Sweden, which is consistent with a higher prevalence of Gaucher's disease in this part of the country. Our findings support the role of GBA mutations as risk factors for PD and point to lysosomal dysfunction as a mechanism contributing to PD etiology. (C) 2016 The Author(s). Published by Elsevier Inc.
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| 10. |
- Sundling, Christopher, et al.
(författare)
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B cell profiling in malaria reveals expansion and remodeling of CD11c+ B cell subsets
- 2019
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 4:9
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Tidskriftsartikel (refereegranskat)abstract
- Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute Plasmodium fakiporum malaria for the first time or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we found that approximately 80% of mature B cells that proliferated in response to acute infection expressed CD11c. Only approximately 40% of CD11c+ B cells displayed an atypical B cell phenotype, with the remaining cells primarily made up of activated and resting memory B cells. The CD11c+ B cells expanded rapidly following infection, with previous exposure to malaria resulting in a significantly larger increase compared with individuals with primary infection. This was attributed to an expansion of switched CD11c+ B cells that was absent in primary infected individuals. The rate of contraction of the CD11c+ B cell compartment was independent of previous exposure to malaria and displayed a slow decay, with a half-life of approximately 300 days. Collectively, these results identify CD11c as a marker of B cells responding to malaria and further highlight differences in primary and secondary B cell responses during infection.
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