Sökning: WFRF:(Brodmerkel Maxim N.)
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Collision induced u...
Collision induced unfolding and molecular dynamics simulations of norovirus capsid dimers reveal strain-specific stability profiles
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- Brodmerkel, Maxim N. (författare)
- Uppsala universitet,Biokemi
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- De Santis, Emiliano, PhD (författare)
- Uppsala universitet,Biokemi,Institutionen för fysik och astronomi
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Uetrecht, Charlotte (författare)
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- Caleman, Carl (författare)
- Uppsala universitet,Kemisk och biomolekylär fysik,Deutsches Elektronen-Synchrotron, DESY, Notkestrasse 85, 22607 Hamburg, Germany
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- Marklund, Erik, Teknologie doktor, 1979- (författare)
- Uppsala universitet,Biokemi
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(creator_code:org_t)
- Royal Society of Chemistry, 2024
- 2024
- Engelska.
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Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry. - 1463-9076 .- 1463-9084.
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Collision induced unfolding is method used with ion mobility mass spectrometry to examine protein structures and their stability. Such experiments yield information about higher order protein structures, yet are unable to provide details about the underlying processes. That information can however be provided using molecular dynamics simulations. Here, we investigate the collision induced unfolding of norovirus capsid dimers from the Norwalk and Kawasaki strains by employing molecular dynamics simulations over a range of temperatures, representing different levels of activation. The dimers have highly similar structures, but the activation reveals differences in the dynamics that arises in response to the activation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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