1. |
|
|
2. |
|
|
3. |
|
|
4. |
- Sheu, KFR, et al.
(författare)
-
A DLST genotype associated with reduced risk for Alzheimer's disease
- 1999
-
Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 52:7, s. 1505-1507
-
Tidskriftsartikel (refereegranskat)abstract
- Article abstract Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial α-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
|
|
5. |
|
|