| 1. |
- Kalman, L. V., et al.
(författare)
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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting
- 2016
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Ingår i: Clinical Pharmacology and Therapeutics. - : WILEY-BLACKWELL. - 0009-9236 .- 1532-6535. ; 99:2, s. 172-185
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Tidskriftsartikel (refereegranskat)abstract
- This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward.
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| 2. |
- Bruckner, Barbara, et al.
(författare)
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A note on extracting electronic stopping from energy spectra of backscattered slow ions applying Bragg's rule
- 2018
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Ingår i: Nuclear Instruments and Methods in Physics Research Section B. - : ELSEVIER SCIENCE BV. - 0168-583X .- 1872-9584. ; 423, s. 82-86
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Tidskriftsartikel (refereegranskat)abstract
- Electronic stopping measurements in chemically reactive targets, e.g., transition and rare earth metals are challenging. These metals often contain low Z impurities, which contribute to electronic stopping. In this article, we present two ways how one can correct for the presence of impurities in the evaluation of proton and He stopping in Ni for primary energies between 1 and 100 keV, either considering or ignoring the contribution of the low Z impurities to multiple scattering. We find, that for protons either method leads to concordant results, but for heavier projectiles, e.g. He ions, the influence on multiple scattering must not be neglected.
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| 3. |
- Farmer, A. D., et al.
(författare)
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Regional gastrointestinal contractility parameters using the wireless motility capsule : inter-observer reproducibility and influence of age, gender and study country
- 2018
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 47:3, s. 391-400
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Tidskriftsartikel (refereegranskat)abstract
- Background:The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres.Methods:Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators.Results:Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.412 vs 122 +/- 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log(e) motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times.Conclusions: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.
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| 4. |
- Roth, D., et al.
(författare)
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Electronic Stopping of Slow Protons in Oxides : Scaling Properties
- 2017
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 119:16
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Tidskriftsartikel (refereegranskat)abstract
- Electronic stopping of slow protons in ZnO, VO2 (metal and semiconductor phases), HfO2, and Ta2O5 was investigated experimentally. As a comparison of the resulting stopping cross sections (SCS) to data for Al2O3 and SiO2 reveals, electronic stopping of slow protons does not correlate with electronic properties of the specific material such as band gap energies. Instead, the oxygen 2p states are decisive, as corroborated by density functional theory calculations of the electronic densities of states. Hence, at low ion velocities the SCS of an oxide primarily scales with its oxygen density.
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| 5. |
- Roth, D., et al.
(författare)
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Electronic Stopping of Slow Protons in Transition and Rare Earth Metals : Breakdown of the Free Electron Gas Concept
- 2017
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 118:10
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Tidskriftsartikel (refereegranskat)abstract
- The electronic stopping cross sections (SCS) of Ta and Gd for slow protons have been investigated experimentally. The data are compared to the results for Pt and Au to learn how electronic stopping in transition and rare earth metals correlates with features of the electronic band structures. The extraordinarily high SCS observed for protons in Ta and Gd cannot be understood in terms of a free electron gas model, but are related to the high densities of both occupied and unoccupied electronic states in these metals.
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| 6. |
- Konemann, S., et al.
(författare)
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Combination of In Situ Feeding Rate Experiments and Chemical Body Burden Analysis to Assess the Influence of Micropollutants in Wastewater on Gammarus pulex
- 2019
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Ingår i: Int J Environ Res Public Health. - : MDPI AG. - 1660-4601. ; 16:5
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Tidskriftsartikel (refereegranskat)abstract
- Wastewater discharge is one of the main sources of micropollutants within the aquatic environment. To reduce the risks for the aquatic environment, the reduction of the chemical load of wastewater treatment plant effluent is critical. Based on this need, additional treatment methods, such as ozonation, are currently being tested in several wastewater treatment plants (WWTPs). In the present study, effects were investigated using in situ feeding experiments with Gammarus pulex and body burden analyses of frequently detected micropollutants which used a Quick Easy Cheap Effective Rugged and Safe (QuEChERS) multi-residue method to quantify internal concentrations in collected gammarids. Information obtained from these experiments complemented data from the chemical analysis of water samples and bioassays, which predominantly cover hydrophilic substances. When comparing up- and downstream feeding rates of Gammarus pulex for seven days, relative to the WWTPs, no significant acute effects were detected, although a slight trend of increased feeding rate downstream of the WWTP Aachen-Soers was observed. The chemical load released by the WWTP or at other points, or by diffuse sources, might be too low to lead to clear acute effects on G. pulex. However, some compounds found in wastewater are able to alter the microbial community on its leaves, leading to an increase in the feeding rate of G. pulex. Chemical analysis of internal concentrations of pollutants in the tissues of collected gammarids suggests a potential risk for chronic effects with the chemicals imidacloprid, thiacloprid, carbendazim, and 1H-benzotriazole when exceeding the critical toxic unit value of -3. This study has demonstrated that a combination of acute testing and measurement of the internal concentration of micropollutants that might lead to chronic effects is an efficient tool for investigating river systems, assuming all relevant factors (e.g., species or season) are taken into account.
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| 7. |
- Mueller, Michael, et al.
(författare)
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Microstructural, mechanical, and thermo-physical characterization of hypereutectic AlSi40 fabricated by selective laser melting
- 2019
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Ingår i: Journal of laser applications. - : Laser Institute of America. - 1042-346X .- 1938-1387. ; 31:2
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Tidskriftsartikel (refereegranskat)abstract
- The powder bed additive manufacturing process selective laser melting (SLM) enables designers and engineers to overcome restrictions of conventional manufacturing technologies. The potential of fabricating complex lightweight structures and processing advanced materials is a key feature for enhancing further development of high performance components for space applications. Due to a high specific stiffness and a thermal expansion coefficient very close to electroless nickel, which is an advantageous optical coating material, the hypereutectic aluminum-silicon alloy AlSi40 shows great potential for the manufacturing of optical mirrors for space applications. In prior investigations, Hilpert et al.showed the feasibility to process AlSi40 by SLM [E. Hilpert and S. Risse, Materials Science & Technology Conference and Exhibition MS&T'15, Columbus, Ohio, 4–8 October 2015(Association for Iron & Steel Technology, Warrendale, PA, 2015) and E. Hilpert, “Struktur und Eigenschaften von additiv gefertigten hypereutektischen Aluminum-Siliciumlegierungen,” in Werkstoffwoche 2017, Dresden, Germany, 28 September 2017 (Deutsche Gesellschaft für Materialkunde e.V., Berlin, 2017)]. Nevertheless, in order to qualify this material for space applications, the manufacturing process and fabricated samples need to be thoroughly investigated in terms of microstructural, mechanical, as well as thermo-physical characterization. The authors present results of the SLM process development for manufacturing dense AlSi40 samples with a relative density above 99.50%. The effect of various process parameters, such as hatch distance, preheating, and scanning strategy, on the formation of defects was investigated by destructive [e.g., optical microscopy (OM)] and nondestructive (e.g., computed tomography) testing. In addition, the effect of several thermal post-treatments on the AlSi40 microstructure was profoundly analyzed by multiple methods such as OM, scanning electron microscopy, and energy dispersive x-ray spectroscopy analysis. Moreover, mechanical and thermo-physical testing of manufactured specimens was conducted to provide material characteristics for component design. In conclusion, the determined material properties of AlSi40 samples fabricated by SLM were compared to bulk material properties. The gained knowledge and testing data were evaluated in order to identify correlations and dependencies.
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