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Preoperative accele...
Preoperative accelerated radiotherapy combined with chemotherapy in a defined cohort of patients with high risk soft tissue sarcoma : a Scandinavian Sarcoma Group study
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- Sundby Hall, Kirsten (författare)
- Oslo Univ Hosp, Norwegian Radium Hosp, Dept Oncol, Oslo, Norway
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- Bruland, Øyvind S. (författare)
- Oslo Univ Hosp, Norwegian Radium Hosp, Dept Oncol, Oslo, Norway; Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway
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- Bjerkehagen, Bodil (författare)
- Oslo Univ Hosp, Norwegian Radium Hosp, Dept Pathol, Oslo, Norway; Univ Oslo, Inst Oral Biol, Fac Dent, Oslo, Norway
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- Lidbrink, Elisabet (författare)
- Karolinska Univ Hosp, Dept Med Oncol, Stockholm, Sweden
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- Jebsen, Nina (författare)
- Univ Bergen, Dept Oncol, Haukeland Univ Hosp, Bergen, Norway; Univ Bergen, Dept Orthoped, Haukeland Univ Hosp, Bergen, Norway; Univ Bergen, Ctr Canc Biomarkers CCBIO, Bergen, Norway
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- Hagberg, Hans (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi
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- Papworth, Karin (författare)
- Norrlands Univ Hosp, Dept Oncol, Umeå, Sweden
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- Hagberg, Oskar (författare)
- Lund Univ, Inst Translat Med, Malmö, Sweden
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- Trovik, Clement (författare)
- Haukeland Hosp, Dept Musculoskeletal Tumor Serv Orthoped, Bergen, Norway
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- Bauer, Henrik (författare)
- Karolinska Univ Hosp, Musculoskeletal Tumor Serv, Stockholm, Sweden
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- Eriksson, Mikael (författare)
- Skåne Univ Hosp, Dept Oncol, Lund, Sweden; Lund Univ, Lund, Sweden
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Bruland, OS (författare)
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(creator_code:org_t)
- 2020-11-17
- 2020
- Engelska.
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Ingår i: Clinical Sarcoma Research. - : Springer Science and Business Media LLC. - 2045-3329. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://clinicalsarc...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundWe recently reported outcomes from a Scandinavian Sarcoma Group adjuvant study (SSG XX group A) conducted on localized and operable high risk soft tissue sarcoma (STS) of the extremities and trunk wall. SSG XX, group B, comprised of patients in a defined cohort with locally advanced STS considered at high risk for intralesional surgery. These patients received preoperative accelerated radiotherapy, together with neoadjuvant and adjuvant chemotherapy. Herein we report the results of this group B.MethodsTwenty patients with high-grade, locally advanced and deep STS located in lower extremities (n = 12), upper extremities (5) or trunk wall (3) were included. The median age was 59 years and 14 patients were males. The treatment regimen consisted of 6 cycles of doxorubicin (60 mg/m2) and ifosfamide (6 g/m2), with three cycles given neoadjuvantly, and preoperative radiotherapy (1, 8 Gyx2/daily to 36 Gy) between cycles 2 and 3. After a repeated MRI surgery was then conducted, and the remaining 3 chemotherapy cycles were given postoperatively at 3 weeks intervals. Survival data, local control, toxicity of chemotherapy and postoperative complications are presented.ResultsMedian follow-up time for metastasis-free survival (MFS) was 2.8 years (range 0.3–10.4). The 5-year MFS was 49.5% (95% confidence interval [CI] 31.7–77.4). The median follow-up time was 5.4 years (range 0.3–10.4) for overall survival (OS). The 5-year OS was 64.0% (95% CI 45.8–89.4). The median tumour size was 13 cm, with undifferentiated pleomorphic sarcoma (n = 10) and synovial sarcoma (n = 6) diagnosed most frequently. All patients completed surgery. Resection margins were R0 in 19 patients and R1 in 1 patient. No patients had evidence of disease progression preoperatively. Three patients experienced a local recurrence, in 2 after lung metastases had already been diagnosed. Eleven patients (55%) had postoperative wound problems (temporary in 8 and persistent in 3).ConclusionsPreoperative chemotherapy and radiotherapy were associated with temporary wound-healing problems. Survival outcomes, local control and toxicities were deemed satisfactory when considering the locally advanced sarcoma disease status at primary diagnosis.Trial registration This study was registered at ClinicalTrials.gov Identifier NCT00790244 and with European Union Drug Regulating Authorities Clinical Trials No. EUDRACT 2007-001152-39
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Soft tissue sarcoma
- Preoperative
- Adjuvant
- Chemotherapy
- Radiotherapy
- Accelerated
- Survival
- Toxicity
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- art (ämneskategori)
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Lidbrink, Elisab ...
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Jebsen, Nina
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Hagberg, Hans
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Papworth, Karin
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Hagberg, Oskar
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Trovik, Clement
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Bauer, Henrik
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Eriksson, Mikael
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Bruland, OS
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