| 1. |
- Björk, Tabita, 1966-, et al.
(författare)
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Laterality, hand control and scholastic performance : a British birth cohort study
- 2012
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Ingår i: BMJ Open. - London, United Kingdom : BMJ. - 2044-6055. ; 2:2, s. e000314-
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To use simple measures of laterality and hand control that can identify a greater risk of poorer scholastic ability, potentially signalling suboptimal hemispheric lateralisation.Design: Analysis of material from a birth cohort study.Setting: Members of the National Child Development Study, a British birth cohort study following people born in 1958.Participants: 10 612 children who undertook tests at age 11 years.Primary outcome measures: Teacher-administered tests of non-verbal general ability, verbal general ability, reading comprehension and mathematics. Results Linear regression produced associations (and 95% CIs) with tests of verbal general ability, non-verbal general ability, reading comprehension and mathematics scores for the lowest third (compared with highest) of a left-hand control test involving picking up matches of −1.21 (−1.73 to −0.68; p<0.001), −0.72 (−1.14 to −0.29; p=0.001), −0.70 (−1.06 to −0.35; p<0.001) and −1.32 (−1.90 to −0.73; p<0.001). Among those in the lowest third of the right-hand control test score, mixed-handedness compared with right-handedness was associated with poorer scholastic performance, with regression coefficients (and 95% CIs; p values) of 1.90 (−3.01 to −0.80; p=0.001), −1.25 (−2.15 to −0.35; p=0.007), −1.28 (2.04 to −0.53; p=0.001) and −1.33 (−2.53 to −0.13; p=0.030). The estimates are for a point change in the scholastic test scores, after adjustment for sex, left-hand motor function and social class. Statistically significant associations with mixed-handedness were only observed for the lowest third of right-hand motor function.Conclusions Measures involving poorer left-hand motor function may represent useful markers of reduced cognitive function possibly reflecting suboptimal hemispheric lateralisation. Crude measures of laterality such as reported non-right-handedness may be more useful for research when combined with measures of motor function.
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| 2. |
- Montgomery, SM, et al.
(författare)
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CHILDHOOD HEARING AND ADULT OBESITY
- 2010
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Ingår i: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. - 1070-5503. ; 17, s. 33-33
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Montgomery, Scott M., et al.
(författare)
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Sex differences in childhood hearing impairment and adult obesity
- 2010
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Ingår i: Longitudinal and Life Course Studies. - 1757-9597. ; 1:4, s. 359-370
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Tidskriftsartikel (refereegranskat)abstract
- Some adult neurological complications of obesity may have early-life origins. Here, we examine associations of childhood hearing impairment with childhood and adult obesity, among 3288 male and 3527 female members of a longitudinal cohort born in Great Britain in 1970. Height and weight were measured at age 10 years and self-reported at 34 years. Audiometry was conducted at age 10 years. The dependent variable in logistic regression was minor bilateral hearing impairment as a marker of systemic effects, while BMI at age 10 or 34 years were modelled as independent variables with adjustment for potential confounding factors including social class, maternal education and pubertal development at age 10 years. Among females, the adjusted odds ratios (and 95% confidence intervals) for hearing impairment at age 10 years were 2.33 (1.36-3.98) for overweight/obesity; and at age 34 years they were 1.71 (1.00-2.92) for overweight and 2.73 (1.58-4.71) for obesity and the associations were not explained by Childhood BMI at age 10 years. There were no consistent associations among males and interaction testing revealed statistically significant effect modification by sex. The dose-dependent associations among females are consistent with childhood origins for some obesity-associated impaired neurological function and the possible existence of a 'pre-obese syndrome'. The accumulation of risks for poorer health among those who become obese in later life begins in childhood. Childhood exposures associated with bilateral hearing impairment are risks for obesity in later life among females.
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| 4. |
- Uijterschout, L., et al.
(författare)
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The value of Ret-Hb and sTfR in the diagnosis of iron depletion in healthy, young children
- 2014
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Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 68:8, s. 882-886
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Reticulocyte hemoglobin (Ret-Hb) content and soluble transferrin receptor (sTfR) are described as promising biomarkers in the analysis of iron status. However, the value of Ret-Hb and sTfR in the early detection of iron depletion, as frequently observed in children in high-income countries, is unclear. We hypothesized that young children to iron depletion, using the WHO cutoff of ferritin < 12 mu g/l, would have lower Ret-Hb and higher sTfR concentrations compared to children with a ferritin >= level 12 mu g/l.SUBJECTS/METHODS: In this cross-sectional study, we analyzed mean concentrations of Ret-Hb and sTfR in 351 healthy children aged 0.5-3 years in a high-income country. The Student's t-test was used to compare Ret-Hb and sTfR concentrations between groups.RESULTS: We showed that concentrations of Ret-Hb and sTfR are similar in children with and without iron depletion. A decrease in Ret-Hb concentration was present only when ferritin concentrations were < 8 mu g/l. sTfR concentrations were similar in children with ferritin concentrations < 6 mu g/l and >= 12 mu g/l.CONCLUSIONS: Our results showed that the discriminative value of Ret-Hb and sTfR for the detection of iron depletion is limited. Our findings suggest that ferritin is the most useful biomarker in the screening of iron depletion in healthy children in high-income countries. However, ideally, reference ranges of iron status biomarkers should be based on studies showing that children with concentrations outside reference ranges have poor neurodevelopmental outcomes.
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