| 1. |
- Ajore, Ram, et al.
(författare)
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Functional dissection of inherited non-coding variation influencing multiple myeloma risk
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Thousands of non-coding variants have been associated with increased risk of human diseases, yet the causal variants and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel reporter assays (MPRA), expression analyses (eQTL, meQTL, PCHiC) and chromatin accessibility analyses in primary cells (caQTL), we investigate 1,039 variants associated with multiple myeloma (MM). We demonstrate that MM susceptibility is mediated by gene-regulatory changes in plasma cells and B-cells, and identify putative causal variants at six risk loci (SMARCD3, WAC, ELL2, CDCA7L, CEP120, and PREX1). Notably, three of these variants co-localize with significant plasma cell caQTLs, signaling the presence of causal activity at these precise genomic positions in an endogenous chromosomal context in vivo. Our results provide a systematic functional dissection of risk loci for a hematologic malignancy.
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| 2. |
- Morero, B., et al.
(författare)
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Integrated Waste Management : Adding Value to Oil and Gas Industry Residues Through Co-processing
- 2023
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Ingår i: Waste and Biomass Valorization. - : Springer Science and Business Media LLC. - 1877-2641 .- 1877-265X. ; 14:4, s. 1391-1412
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Tidskriftsartikel (refereegranskat)abstract
- In developing countries, the sustainable management of materials into a circular economy framework is conditioned by several constraints, being economic limitations one of the most relevant. Integrated waste management could effectively aid in overcoming them. This work presents an exhaustive analysis from both economic and environmental points of view addressing the selection and design of treatment alternatives for the integrated management of urban and industrial wastes. We propose a mixed-integer mathematical programming formulation to determine the optimal set of treatments to convert wastes into energy, marketable products or innocuous materials, and we endorse the environmental performance through a life cycle analysis. In our case study, urban wastes include sewage sludge and municipal solid waste, while industrial wastes come from two sources: drill cuttings (an important oil and gas industry residue) and seasonal pomace waste from fruit processing. Treatment alternatives comprise anaerobic digestion, composting, recycling, bioremediation, compost amendment, thermal desorption and final disposal in landfill. Results for different scenarios show that even though the most profitable alternative is to dispose drill cuttings in landfills while processing organic wastes by anaerobic digestion, integrated management using biological treatment alternatives provides a more sustainable and still profitable strategy. We also demonstrate that the process integration increases the profitability and reduces the environmental impact significantly when compared with separate treatment alternatives for waste streams. Graphical abstract: [Figure not available: see fulltext.]
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| 3. |
- Ponticelli, Francesco, et al.
(författare)
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Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study.
- 2021
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Ingår i: International journal of cardiology. - : Elsevier BV. - 1874-1754 .- 0167-5273. ; 337, s. 29-37
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Tidskriftsartikel (refereegranskat)abstract
- Refractory angina (RA) is considered the end-stage of coronary artery disease, and often has no interventional treatment options. Coronary sinus Reducer (CSR) is a recent addition to the therapeutic arsenal, but its efficacy has only been evaluated on small populations. The RESOURCE registry provides further insights into this therapy.The RESOURCE is an observational, retrospective registry that includes 658 patients with RA from 20 centers in Europe, United Kingdom and Israel. Prespecified endpoints were the amelioration of anginal symptoms evaluated with the Canadian Cardiovascular Society (CCS) score, the rates of procedural success and complications, and MACEs as composite of all-cause mortality, acute coronary syndromes, and stroke.At a median follow-up of 502days (IQR 225-1091) after CSR implantation, 39.7% of patients improved by ≥2 CCS classes (primary endpoint), and 76% by ≥1 class. Procedural success was achieved in 96.7% of attempts, with 3% of procedures aborted mostly for unsuitable coronary sinus anatomy. Any complication occurred in 5.7% of procedures, but never required bailout surgery nor resulted in intra- or periprocedural death or myocardial infarction. One patient developed periprocedural stroke after inadvertent carotid artery puncture. At the last available follow-up, overall mortality and MACE were 10.4% and 14.6% respectively. At one, three and five years, mortality rate at Kaplan-Meier analysis was 4%, 13.7%, and 23.4% respectively.CSR implantation is safe and reduces angina in patients with refractory angina.
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