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- Perez-Nadales, Elena, et al.
(författare)
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Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales : The impact of cytomegalovirus disease and lymphopenia
- 2020
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Ingår i: American Journal of Transplantation. - : WILEY. - 1600-6135 .- 1600-6143. ; 20:6, s. 1629-1641
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Tidskriftsartikel (refereegranskat)abstract
- Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score >= 8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score >= 8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
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- Nguyen, F., et al.
(författare)
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Undulators and Light Production with the XLS-CompactLight Design Study
- 2022
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Ingår i: MOSCOW UNIVERSITY PHYSICS BULLETIN. - : Allerton Press. - 0027-1349 .- 1934-8460. ; 77:2, s. 241-244
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Tidskriftsartikel (refereegranskat)abstract
- Free electron laser (FEL) facilities provide broadly tunable and highly coherent photon beams. These machines still have an unexplored potential and development. The XLS-CompactLight design aims at a flexible hard plus soft X-ray FEL facility exploiting the latest concepts in terms of short period magnetic undulators, paving the road towards more compact photon sources.
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- Cafiso, S., et al.
(författare)
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Zastosowanie i porównanie różnych metod analizy konfliktów ruchowych - Studium przypadku drogi 2+1
- 2021
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Ingår i: Archives of Civil Engineering. - 1230-2945. ; 67:1, s. 619-634
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Tidskriftsartikel (refereegranskat)abstract
- Safety Performance Functions and Crash Modification Factors are statistically-based prediction methods that require significant efforts and long periods in crash data collection. Traffic conflict studies can mitigate this issue using a short time survey to measure the number and severity of traffic conflicts, which are regarded as surrogate safety measures. Unfortunately, they are empirical studies that can be carried out only after the implementation of a treatment. The overall objective of the present research is to investigate the performance of different methods for conflict detection and classification, considering the observed conflicts on 2+1 roads in Poland. Observations were compared with conflicts detected in simulated environments. The latter include either the Agent-Based Microsimulation (ABM) approach, or the virtual reality simulation using a Driving Simulator (DS). Conflicts were detected and classified based on video recording and analysis of vehicle trajectories in the merging area of 2+1 roads. The studies focused only on lane-changing conflicts. Locations, Post Encroachment Time and Time to Collision values of observed conflicts between vehicles were subsequently identified. Observed conflicts were compared with the ones resulting from ABM and DS, to determine whether there is a correlation between them.
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