| 1. |
- Aamodt, K., et al.
(författare)
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The ALICE experiment at the CERN LHC
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08002
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Forskningsöversikt (refereegranskat)abstract
- ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries, Its overall dimensions are 16 x 16 x 26 m(3) with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008.
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| 2. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 3. |
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| 4. |
- Cao, J., et al.
(författare)
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A monolithic ultra-compact inp o-cdma encoder with : Planarization by hvpe regrowth
- 2006
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Ingår i: OFC/NFOEC. - : Optical Society of America. - 1557528020 - 9781557528025
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Konferensbidrag (refereegranskat)abstract
- We report a monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip in InP with surface planarization by low-pressure Hydride-Vapor-Phase-Epitaxy regrowth. The chip consists of an AWG pair and eight electro-optic phase shifters and demonstrated excellent encoding operation.
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| 5. |
- Cao, J., et al.
(författare)
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A monolithic ultra-compact inp o-cdma encoder with : Planarization by hvpe regrowth
- 2005
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Ingår i: Optics InfoBase Conference Papers. - : Optics Info Base, Optical Society of America. - 1557527849 - 9781557527844
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Konferensbidrag (refereegranskat)abstract
- We report a monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip in InP with surface planarization by low-pressure Hydride-Vapor-Phase-Epitaxy regrowth. The chip consists of an AWG pair and eight electro-optic phase shifters and demonstrated excellent encoding operation.
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| 6. |
- Cao, J., et al.
(författare)
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Error-free spectral encoding and decoding operation of InP O-CDMA encoder
- 2006
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Ingår i: 2006 Optical Fiber Communication Conference, and the 2006 National Fiber Optic Engineers Conference. - : IEEE. - 1557528039 - 9781557528032
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Konferensbidrag (refereegranskat)abstract
- We report error-free spectral encoding and decoding operation of an InP monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip pair. The experimental results demonstrate the strong potential for realizing high performance O-CDMA networks with InP micro-systems.
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| 7. |
- Cao, J., et al.
(författare)
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Spectral encoding and decoding of monolithic InP OCDMA encoder
- 2005
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Ingår i: 31st European Conference on Optical Communications (ECOC 2005), 2005. - : Institution of Engineering and Technology. ; , s. 501-502
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Konferensbidrag (refereegranskat)abstract
- We report the optical-coding operation of monolithic, ultra-compact optical-CDMA encoder and decoder pair, consisting of InP based integrated AWGs and phase modulators. The encoder and decoder successfully demonstrate eight-bit Walsh code based encoding and decoding.
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| 8. |
- Cao, RH, et al.
(författare)
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Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action
- 2006
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 107:9, s. 3531-3536
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Tidskriftsartikel (refereegranskat)abstract
- Hepatocyte growth factor (HGF) has previously been reported to act as a hemangiogenic factor, as well as a mitogenic factor for a variety of tumor cells. Here, we demonstrate that HGF is a lymphangiogenic factor, which may contribute to lymphatic metastasis when overexpressed in tumors. In a mouse corneal lymphangiogenesis model, implantation of HGF induces sprouting and growth of new lymphatic vessel expressing the lymphatic vessel endothelial specific marker hyaluronan receptor-1 (Lyve-1). Unlike blood vessels, the Lyve-1–positive structures consist of blunt-ended vessels of large diameters that generally lack expression of CD31. The growth of HGF-induced lymphatic vessels can be partially blocked by a soluble VEGFR-3, suggesting that HGF may stimulate lymphatic vessel growth through an indirect mechanism. Consistent with this finding, the HGF receptor (c-Met) is only localized on corneal blood vessels but is absent on lymphatic vessels in a mouse corneal assay. In a transgenic mouse model that expresses HGF under the control of the whey acidic protein (WAP) gene promoter, transgenic females develop tumors in the mammary glands after several pregnancies. Interestingly, dilated Lyve-1–positive lymphatic vessels accumulate in the peritumoral area and occasionally penetrate into the tumor tissue. Our findings indicate that HGF may play a critical role in lymphangiogenesis and potentially contribute to lymphatic metastasis.
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| 9. |
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| 10. |
- Ji, C., et al.
(författare)
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Monolithically integrated InP-based photonic chip development for O-CDMA systems
- 2005
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Ingår i: IEEE Journal of Selected Topics in Quantum Electronics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1077-260X .- 1558-4542. ; 11:1, s. 66-77
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Tidskriftsartikel (refereegranskat)abstract
- This paper discusses photonic integration efforts toward developing an InP-based inonolithically integrated photonic chip for optical code-division multiple-access (O-CDMA) system applications. The chip design includes the colliding pulsed mode (CPM) locked laser, the. Mach-Zehnder interferometer-based threshold detector (MZI), and the monolithic O-CDMA encoder/decoder chip based on array-waveguide-gratings and phase modulator arrays. The compact 4 x I cm monolithic chip can replace a complex and large O-CDMA setup based on bulk optics. The integration technique involves active-passive integration using dry etching, metal organic chemical vapor deposition growth, and lateral hydride vapor phase epitaxy regrowth technologies. The fabricated CPM showed stable 1.54 ps modelocked laser output, the MZI showed excellent O-CDMA threshold detection, and the O-CDMA encoder showed Walsh-code O-CDMA, encoding. Further, the fabricated devices showed excellent planarity, which accelerate our progress toward monolithic integration of O-CDMA systems.
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