| 1. |
- Costa, Pedro Alves, et al.
(författare)
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Influence of soil non-linearity on the dynamic response of high-speed railway tracks
- 2010
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Ingår i: Soil Dynamics and Earthquake Engineering. - : Elsevier BV. - 0267-7261 .- 1879-341X. ; 30:4, s. 221-235
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Tidskriftsartikel (refereegranskat)abstract
- The main objectives of this paper are the evaluation of the relevance of the non-linear behaviour of the soil on the track response and the validation of a methodology, which includes these effects through an equivalent linear analysis. The proposed numerical model is based on 2.5D finite/infinite elements method, coupled with an iterative procedure in order to obtain an agreement between the strain levels and the dynamicproperties of the materials. In order to validate the model, the case study of Ledsgard was simulated, and the experimental and numerical results of displacements of the trackwere compared, considering several circulation speeds for the X2000 train. From the results, it is possible to recognize that the stiffness degradation, function of the strain level, plays a relevant role for the case of high-speed railway lines on soft ground. Moreover, the simulations developed with the proposed methodology provided similar results to those observed, independently of the train speed, contrary to what was obtained when the elastic linear model was used.
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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 3. |
- O'Donovan, Tony, et al.
(författare)
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The GINSENG system for wireless monitoring and control : Design and deployment experiences
- 2013
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Ingår i: ACM transactions on sensor networks. - : Association for Computing Machinery (ACM). - 1550-4867 .- 1550-4859. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Today's industrial facilities, such as oil refineries, chemical plants, and factories, rely on wired sensor systems to monitor and control the production processes. The deployment and maintenance of such cabled systems is expensive and inflexible. It is, therefore, desirable to replace or augment these systems using wireless technology, which requires us to overcome significant technical challenges. Process automation and control applications are mission-critical and require timely and reliable data delivery, which is difficult to provide in industrial environments with harsh radio environments. In this article, we present the GINSENG system which implements performance control to allow us to use wireless sensor networks for mission-critical applications in industrial environments. GINSENG is a complete system solution that comprises on-node system software, network protocols, and back-end systems with sophisticated data processing capability. GINSENG assumes that a deployment can be carefully planned. A TDMA-based MAC protocol, tailored to the deployment environment, is employed to provide reliable and timely data delivery. Performance debugging components are used to unintrusively monitor the system performance and identify problems as they occur. The article reports on a real-world deployment of GINSENG in an especially challenging environment of an operational oil refinery in Sines, Portugal. We provide experimental results from this deployment and share the experiences gained. These results demonstate the use of GINSENG for sensing and actuation and allow an assessment of its ability to operate within the required performance bounds. We also identify shortcomings that manifested during the evaluation phase, thus giving a useful perspective on the challenges that have to be overcome in these harsh application settings.
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| 4. |
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| 5. |
- Schön, Lennart, et al.
(författare)
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The Rise of the Fiscal State in Sweden 1800-1914
- 2010
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Ingår i: Paying for the Liberal State. The Rise of Public Finance in Nineteenth-Century Europe. - 9780521518529 ; , s. 162-185
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Soares, Pedro, et al.
(författare)
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Climatology of Iberia Coastal Low-Level Wind Jet : WRF High Resolution Results
- 2014
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Ingår i: Tellus. Series A, Dynamic meteorology and oceanography. - : Stockholm University Press. - 0280-6495 .- 1600-0870. ; 66, s. 22377-
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Tidskriftsartikel (refereegranskat)abstract
- Coastal low level jets are a low-tropospheric wind feature driven by the pressure gradient produced by a sharp contrast between high temperatures over land and lower temperatures over the sea. This contrast between the cold ocean and the warm land in the summer is intensified by the impact of the coast-parallel winds on the ocean generating upwelling currents, sharpening the temperature gradient close to the coast, and giving rise to strong baroclinic structures at the coast.During summertime the Iberian Peninsula is often under the effect of the Azores High and a thermal low pressure system inland, leading to a seasonal wind, in the west coast, called the Nortada (northerly wind). This study presents climatology of the costal low level jet off the west coast of the Iberian Peninsula, based on a high resolution (9 km) downscaling data produced using the WRF mesoscale model, forced by 20 years of ERA-Interim reanalysis (1989-2008). The simulation results show that the jet hourly frequency of occurrence in summer is above 30%, and decreases for about 10% in spring and autumn. The monthly frequencies of occurrence can reach higher values, around 40% in summer months, and reveal large inter-annual variability in all the three seasons. In summer, on a daily basis, the low level jet is present in almost 70% of the days. The jet wind direction is mostly from north-northeasterly, and occurs more persistently in three areas, where the interaction of the jet flow with local capes and headlands are more pronounced. The jet occurs at heights between 300 and 400 m, and its speed has a median around 15 m s-1, reaching maximum speeds of 25 m s-1.
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| 7. |
- Soares, Pedro M. M., et al.
(författare)
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Climatology of the Iberia coastal low-level wind jet : weather research forecasting model high-resolution results
- 2014
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Ingår i: Tellus. Series A, Dynamic meteorology and oceanography. - : Stockholm University Press. - 0280-6495 .- 1600-0870. ; 66, s. 22377-
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Tidskriftsartikel (refereegranskat)abstract
- Coastal low-level jets (CLLJ) are a low-tropospheric wind feature driven by the pressure gradient produced by a sharp contrast between high temperatures over land and lower temperatures over the sea. This contrast between the cold ocean and the warm land in the summer is intensified by the impact of the coastal parallel winds on the ocean generating upwelling currents, sharpening the temperature gradient close to the coast and giving rise to strong baroclinic structures at the coast. During summertime, the Iberian Peninsula is often under the effect of the Azores High and of a thermal low pressure system inland, leading to a seasonal wind, in the west coast, called the Nortada (northerly wind). This study presents a regional climatology of the CLLJ off the west coast of the Iberian Peninsula, based on a 9km resolution downscaling dataset, produced using the Weather Research and Forecasting (WRF) mesoscale model, forced by 19 years of ERA-Interim reanalysis (1989-2007). The simulation results show that the jet hourly frequency of occurrence in the summer is above 30% and decreases to about 10% during spring and autumn. The monthly frequencies of occurrence can reach higher values, around 40% in summer months, and reveal large inter-annual variability in all three seasons. In the summer, at a daily base, the CLLJ is present in almost 70% of the days. The CLLJ wind direction is mostly from north-northeasterly and occurs more persistently in three areas where the interaction of the jet flow with local capes and headlands is more pronounced. The coastal jets in this area occur at heights between 300 and 400 m, and its speed has a mean around 15 m/s, reaching maximum speeds of 25 m/s.
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