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- Åkesson, Torsten, et al.
(författare)
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Tracking performance of the transition radiation tracker prototype for the ATLAS experiment
- 2002
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 485:3, s. 298-310
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Tidskriftsartikel (refereegranskat)abstract
- A prototype of the Transition Radiation Tracker (TRT) for the ATLAS experiment at the CERN LHC has been built and tested at the CERN SPS. Detailed studies of the drift-time measurements, alignment technique, hit registration efficiency, track and momentum accuracy were performed. A coordinate measurement accuracy of 150 Pin for a single TRT drift tube and momentum resolution of 0.8% for 20 GeV pions in a 1.56 T magnetic field were achieved. The results obtained are in agreement with the expected tracking performance of the ATLAS TRT. (C) 2001 Published by Elsevier Science B.V.
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- Carling, K. M., et al.
(författare)
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Vacancy concentration in Al from combined first-principles and model potential calculations
- 2003
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 67:5
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Tidskriftsartikel (refereegranskat)abstract
- We present a comprehensive study of vacancy formation enthalpies and entropies in aluminum. The calculations are done in the framework of the local-density and generalized-gradient approximations in the density-functional formalism. To assess anharmonic contributions to the formation free energies, we use an interatomic potential with parameters determined from density-functional-theory calculations. We find that the binding energy for the nearest-neighbor divacancy is negative, i.e., it is energetically unstable. The entropy contributions slightly stabilize the divacancy but also the binding free energy at the melting temperature is found to be negative. We show that the anharmonic atomic vibrations explain the non-Arrhenius temperature dependence of the vacancy concentration in contrast to the commonly accepted interpretation of the experimental data in terms of the monovacancy-divacancy model.
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- Villablanca, A, et al.
(författare)
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Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism
- 2002
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Ingår i: European journal of endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 147:3, s. 313-322
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Familial isolated hyperparathyroidism (FIHP) is a hereditary disorder characterised by uni- or multiglandular parathyroid disease. A subset of families are likely to be genetic variants of other familial tumour syndromes in which PHPT is the main feature, for example multiple endocrine neoplasia type 1 (MEN 1) and the hyperparathyroidism-jaw tumour syndrome (HPT-JT). OBJECTIVE: To investigate seven families diagnosed with FIHP, each with two to eight affected family members, to clarify the underlying genetic mechanism. METHODS: The entire MEN1 gene was sequenced for germline mutations and, in addition, tumour specimens were analysed in comparative genomic hybridisation and loss of heterozygosity studies. RESULTS: Two families exhibited MEN1 mutations, L112V and 1658delG, which were associated with loss of the wild-type 11q13 alleles in all tumours analysed. In the remaining five families, no MEN1 mutation was identified. CONCLUSION: These results support the involvement of the MEN1 tumour suppressor gene in the pathogenesis of some of the FIHP kindreds. However, loss on chromosome 11 was seen in all tumours exhibiting somatic deletions, although in two families the tumour deletions involved 11q distal to MEN1. We conclude that the altered MEN1 gene function is of importance in the development of FIHP.
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