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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Raj, Kavita, et al.
(författare)
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Family Mismatched Allogeneic Stem Cell Transplantation for Myelofibrosis : Report from the Chronic Malignancies Working Party of European Society for Blood and Marrow Transplantation
- 2019
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 25:3, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- This analysis included 56 myelofibrosis (MF) patients transplanted from family mismatched donor between 2009 and 2015 enrolled in the European Society for Blood and Marrow Transplantation database. The median age was 57 years (range, 38 to 72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34(+) cell dose was 4.8 x 10(6)/kg (range, 1.7 to 22.9; n = 43). Conditioning was predominantly myeloablative in 70% and reduced intensity in the remainder. Regimens were heterogeneous with thiotepa, busulfan, fludarabine, and post-transplant cyclophosphamide used in 59%. The incidence of neutrophil engraftment by 28 days was 82% (range, 70% to 93%), at a median of 21 days (range, 19 to 23). At 2 years the cumulative incidence of primary graft failure was 9% (95% CI 1% to 16%) and secondary graft failure was 13% (95% CI 4% to 22%). The cumulative incidence of acute graft-versus-host disease (GVHD) grades II to IV and Ill to IV was 28% (95% CI 16% to 40%) and 9% (95% CI 2% to 17%) at 100 days. The cumulative incidence of chronic GVHD at 1 year was 45% (95% CI 32% to 58%), but the cumulative incidence of death without chronic GVHD by 1 year was 20% (95% CI 10% to 31%). With a median follow-up of 32 months, the 1- and 2-year overall survival was 61% (95% CI 48% to 74%) and 56% (95% CI 41% to 70%), respectively. The 1- and 2- year progression-free survival was 58% (95% CI 45% to 71%) and 43% (95% CI 28% to 58%), respectively, with a 2-year cumulative incidence of relapse of 19% 95% CI 7% to 31%). The 2-year nonrelapse mortality was 38% (95% CI 24% to 51%). This retrospective study of MF allo-SCT using family mismatched donors demonstrated feasibility of the approach, timely neutrophil engraftment in over 80% of cases, and acceptable overall and progression-free survival rates with relapse rates not dissimilar to the unrelated donor setting. However, strategies to minimize the risk of graft failure and the relatively high nonrelapse mortality need to be used, ideally in a multicenter prospective fashion.
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| 4. |
- Axelsson, Jakob, et al.
(författare)
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Towards the architecture of a decision support ecosystem for system component selection
- 2017
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Ingår i: 11th Annual IEEE International Systems Conference, SysCon 2017 - Proceedings. - 9781509046225 - 9781509046232
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Konferensbidrag (refereegranskat)abstract
- When developing complex software-intensive systems, it is nowadays common practice to base the solution partly on existing software components. Selecting which components to use becomes a critical decision in development, but it is currently not well supported through methods and tools. This paper discusses how a decision support system for this problem could benefit from a software ecosystem approach, where participants share knowledge across organizations both through reuse of analysis models, and through partially disclosed past decision cases. We show how the ecosystem architecture becomes fundamental to deal with efficient knowledge sharing, while respecting constraints on integrity of intellectual property. A concrete architecture proposal is outlined, which is a web-based distributed system-of-systems. Experiences of a proof-of-concept implementation are also described.
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| 5. |
- Burt, Richard K., et al.
(författare)
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Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis : A Randomized Clinical Trial
- 2019
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Ingår i: Journal of the American Medical Association (JAMA). - : AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 321:2, s. 165-174
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS).OBJECTIVE To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression.DESIGN, SETTING, AND PARTICIPANTS Between September 20, 2005, and July 7, 2016, a total of 110 patients with relapsing-remitting MS, at least 2 relapses while receiving DMT in the prior year, and an Expanded Disability Status Scale (EDSS; score range, 0-10 [10 = worst neurologic disability]) score of 2.0 to 6.0 were randomized at 4 US, European, and South American centers. Final follow-up occurred in January 2018 and database lock in February 2018.INTERVENTIONS Patients were randomized to receive HSCT along with cyclophosphamide (200mg/kg) and antithymocyte globulin (6mg/kg) (n = 55) or DMT of higher efficacy or a different class than DMT taken during the previous year (n = 55).MAIN OUTCOMES AND MEASURES The primary end point was disease progression, defined as an EDSS score increase after at least 1 year of 1.0 point or more (minimal clinically important difference, 0.5) on 2 evaluations 6 months apart, with differences in time to progression estimated as hazard ratios. RESULTS Among 110 randomized patients (73 [66%] women; mean age, 36 [SD, 8.6] years), 103 remained in the trial, with 98 evaluated at 1 year and 23 evaluated yearly for 5 years (median follow-up, 2 years; mean, 2.8 years). Disease progression occurred in 3 patients in the HSCT group and 34 patients in the DMT group. Median time to progression could not be calculated in the HSCT group because of too few events; it was 24 months (interquartile range, 18-48 months) in the DMT group (hazard ratio, 0.07; 95% CI, 0.02-0.24; P < .001). During the first year, mean EDSS scores decreased (improved) from 3.38 to 2.36 in the HSCT group and increased (worsened) from 3.31 to 3.98 in the DMT group (between-group mean difference,-1.7; 95% CI,-2.03 to -1.29; P < .001). There were no deaths and no patients who received HSCT developed nonhematopoietic grade 4 toxicities (such as myocardial infarction, sepsis, or other disabling or potential life-threatening events).CONCLUSIONS AND RELEVANCE In this preliminary study of patients with relapsing-remitting MS, nonmyeloablative HSCT, compared with DMT, resulted in prolonged time to disease progression. Further research is needed to replicate these findings and to assess long-term outcomes and safety.
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| 6. |
- Campeanu, Gabriel, et al.
(författare)
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A GPU-aware Component Model Extension for Heterogeneous Embedded Systems
- 2015
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Ingår i: The Tenth International Conference on Software Engineering Advances ICSEA 2015. - 9781612084381
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Konferensbidrag (refereegranskat)abstract
- One way for modern embedded systems to tackle the demand for more complex functionality requiring more computational power is to take advantage of heterogeneous hardware. These hardware platforms are constructed from the combination of different processing units including both traditional CPUs and for example Graphical Processing Units (GPUs). However, there is a lack of efficient approaches supporting software development for such systems. In particular, modern software development approaches, such as component-based development, do not provide sufficient support for heterogeneous hardware platforms. This paper presents a component model extension, which defines specific features for components with GPU capabilities. The benefits of the proposed solution include an increased system performance by accelerating the communication between GPU-aware components and the possibility to control the distribution of GPU computation resources at system level.
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| 7. |
- Campeanu, Gabriel, et al.
(författare)
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Allocation Optimization for Component-based Embedded Systems with GPUs
- 2018
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Ingår i: 44th Euromicro Conference on Software Engineering and Advanced Applications SEAA 2018. - 9781538673829 ; , s. 101-110
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Konferensbidrag (refereegranskat)abstract
- Platforms equipped with GPU processors help mitigating the ever-increasing computational demands of modern embedded systems. Such systems can be specifically developed by using component-based development thanks to the concept of flexible components. Through this concept, a component can be transparently executed either on a CPU or a GPU. However, this flexibility complicates the allocation process because it adds additional complexity (i.e., due to the undecided CPU or GPU execution) and constraints to consider (i.e., CPUs and GPUs properties). In this work, we address this problem by providing an optimization model for component-based embedded systems executing on both CPU and GPU. The model addresses important optimization goals, characteristic to the embedded system domain, such as memory usage, energy usage and execution time. A novelty of this work is the formal description of the optimization model, which supports the usage of mixed integer nonlinear programming to compute optimal allocation schemes. To examine the feasibility of the proposed method, we apply the optimization model on a vision system constructed using the industrial Rubus component model.
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| 8. |
- Campeanu, Gabriel, et al.
(författare)
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Developing CPU-GPU Embedded Systems using Platform-Agnostic Components
- 2017
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Ingår i: Proceedings - 43rd Euromicro Conference on Software Engineering and Advanced Applications, SEAA 2017. - 9781538621400 ; , s. 176-180
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Konferensbidrag (refereegranskat)abstract
- Nowadays, there are many embedded systems with different architectures that have incorporated GPUs. However, it is difficult to develop CPU-GPU embedded systems using component-based development (CBD), since existing CBD ap- proaches have no support for GPU development. In this context, when targeting a particular CPU-GPU platform, the component developer is forced to construct hardware-specific components, which are problematic to (re-)use in different contexts. More- over, hard-coding specific GPU-usage characteristics (e.g., the number of utilized GPU threads) inside the component is not possible without making detailed assumptions about the system in which the component is used, which conflicts with separation- of-concerns CBD principle. The paper presents a solution to allow component-based development of platform-agnostic CPU-GPU embedded systems through: i) high-level API, ii) adapters, and iii) code template. The API abstracts the specifics of the different platforms, while the adapters externalize hardware-specific activities outside components. We also raise the decision regarding the GPU- usage specifications, from the component to the system level. Furthermore, to minimize the development effort, we provide a code template that contains ready-made code fragments required for GPU development. As a case study, we examine the feasibility of our solution applied on a component-based vision system of an underwater robot.
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| 9. |
- Campeanu, Gabriel, et al.
(författare)
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Extending the Rubus Component Model with GPU-Aware Components
- 2016
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Ingår i: Proceedings - 2016 19th International ACM SIGSOFT Symposium on Component-Based Software Engineering, CBSE 2016. - 9781509025695 ; , s. 59-68
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Konferensbidrag (refereegranskat)abstract
- To support the complex functionality expected of modern embedded systems, the trend is to supplement CPUs with Graphical Processing Units (GPUs), thus creating heterogeneous embedded systems. However, taking full advantage of GPUs increases the complexity of the development and requires dedicated support, and no such support exists in the component models currently available. The only solution today is to completely encapsulate all GPU-specific information and operations within the components, which increases the communication overhead and reduces component reusability, thus significantly limiting the applicability of component-based development to heterogeneous embedded systems. In this paper, we propose to extend Rubus, an industrial component model for embedded systems, with dedicated support for GPUs. We introduce new constructs, including GPU ports and automatically generated adapters to facilitate seamless component communication over the heterogeneous processing units, regardless of whether the components use the CPU, GPU, or both. A running example is used for the problem description, the proposed extension, and to evaluate our solution.
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| 10. |
- Campeanu, Gabriel, et al.
(författare)
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Flexible Components for Development of Embedded Systems with GPUs
- 2017
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Ingår i: 24th Asia-Pacific Software Engineering Conference APSEC 2017. - 9781538636817 ; , s. 219-228
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Konferensbidrag (refereegranskat)abstract
- Today, embedded systems incorporate GPUs through a multitude of different architectures. When it comes to the development of these systems with GPUs, component-based development is ill-equipped as it does not provide support for GPUs. Instead, the component developer needs to encapsulate inside the component, besides functionality, settings and environment information that are specific to a particular GPU architecture. This binds the component this GPU architecture. Using these hardware-specific components characterized by restricted reusability, the system developer is confined to a limited design space which may negatively impact the overall system feasibility. In this paper, we introduce the concept of flexible components, which are components that can be executed indifferently on CPU or GPU, regardless of the architecture. Using flexible components, component developers are relieved from the side development activities (e.g., environment information) which are automatically handled by component-level mechanisms. To enhance component communications, connection elements (i.e., adapters) are generated to handle component data transmission, taking in consideration the platform characteristics. Finally, our proposed solution is evaluated by using flexible components to implement the vision system of an underwater robot, and execute it on three platforms with different GPU architectures.
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