| 1. |
- Machowicz, Rafal, et al.
(författare)
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Allogeneic hematopoietic stem cell transplantation for adult HLH : a retrospective study by the chronic malignancies and inborn errors working parties of EBMT
- 2022
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Ingår i: Bone Marrow Transplantation. - : Springer Nature. - 0268-3369 .- 1476-5365. ; 57:5, s. 817-823
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Tidskriftsartikel (refereegranskat)abstract
- Hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) is a rare syndrome of potentially fatal, uncontrolled hyperinflammation. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is indicated in primary, recurrent or progressive HLH, but information about its outcomes in the adult population is limited. We obtained data about 87 adult (>= 18 years of age) patients retrospectively reported to the EBMT. The median survival time was 13.9 months. The three and five-year overall survival (OS) was 44% (95% CI 33-54%). Among 39 patients with a follow-up longer than 15 months, only three died. Relapse rate was 21% (95% CI 13-30%), while NRM reached 36% (95% CI 25-46%). Younger patients (<30 years of age) had better prognosis, with an OS of 59% (95% CI 45-73%) at three and five years vs 23% (95% CI 8-37%) for older ones. No difference in survival between reduced and myeloablative conditioning was found. To our knowledge, this is the largest report of adult HLH patients who underwent allo-HSCT. Patients who survive the first period after this procedure can expect a long disease-free survival. Both reduced intensity and myeloablative conditioning have therapeutic potential in adult HLH.
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| 2. |
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Accelerating digital transformation : 10 years of software center
- 2022
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- This book celebrates the 10-year anniversary of Software Center (a collaboration between 18 European companies and five Swedish universities) by presenting some of the most impactful and relevant journal or conference papers that researchers in the center have published over the last decade.The book is organized around the five themes around which research in Software Center is organized, i.e. Continuous Delivery, Continuous Architecture, Metrics, Customer Data and Ecosystems Driven Development, and AI Engineering. The focus of the Continuous Delivery theme is to help companies to continuously build high quality products with the right degree of automation. The Continuous Architecture theme addresses challenges that arise when balancing the need for architectural quality and more agile ways of working with shorter development cycles. The Metrics theme studies and provides insight to understand, monitor and improve software processes, products and organizations. The fourth theme, Customer Data and Ecosystem Driven Development, helps companies make sense of the vast amounts of data that are continuously collected from products in the field. Eventually, the theme of AI Engineering addresses the challenge that many companies struggle with in terms of deploying machine- and deep-learning models in industrial contexts with production quality. Each theme has its own part in the book and each part has an introduction chapter and then a carefully selected reprint of the most important papers from that theme.This book mainly aims at researchers and advanced professionals in the areas of software engineering who would like to get an overview about the achievement made in various topics relevant for industrial large-scale software development and management – and to see how research benefits from a close cooperation between industry and academia.
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| 3. |
- Bosch, Jan, 1967, et al.
(författare)
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Accelerating digital transformation: 10 years of software center
- 2022
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This book celebrates the 10-year anniversary of Software Center (a collaboration between 18 European companies and five Swedish universities) by presenting some of the most impactful and relevant journal or conference papers that researchers in the center have published over the last decade. The book is organized around the five themes around which research in Software Center is organized, i.e. Continuous Delivery, Continuous Architecture, Metrics, Customer Data and Ecosystems Driven Development, and AI Engineering. The focus of the Continuous Delivery theme is to help companies to continuously build high quality products with the right degree of automation. The Continuous Architecture theme addresses challenges that arise when balancing the need for architectural quality and more agile ways of working with shorter development cycles. The Metrics theme studies and provides insight to understand, monitor and improve software processes, products and organizations. The fourth theme, Customer Data and Ecosystem Driven Development, helps companies make sense of the vast amounts of data that are continuously collected from products in the field. Eventually, the theme of AI Engineering addresses the challenge that many companies struggle with in terms of deploying machine- and deep-learning models in industrial contexts with production quality. Each theme has its own part in the book and each part has an introduction chapter and then a carefully selected reprint of the most important papers from that theme. This book mainly aims at researchers and advanced professionals in the areas of software engineering who would like to get an overview about the achievement made in various topics relevant for industrial large-scale software development and management - and to see how research benefits from a close cooperation between industry and academia.
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| 4. |
- Sedova, Ksenia A, et al.
(författare)
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Terminal T-wave inversion predicts reperfusion tachyarrhythmias in STEMI
- 2022
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Ingår i: Journal of Electrocardiology. - : Elsevier BV. - 1532-8430 .- 0022-0736. ; 71, s. 28-31
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: A reliable electrocardiographic predictor of ventricular fibrillation (VF) in patients with ST elevation myocardial infarction (STEMI) is lacking so far. Previous experimental/simulation study suggested a terminal T-wave inversion (TTWI) in ischemia-related ECG leads corresponding to anterior infarct localization as an independent predictor of reperfusion VF (rVF). This T-wave characteristic has never been tested as a rVF predictor in clinical settings. The aim of this study was to test if terminal T-wave inversion (TTWI) at admission ECG (before reperfusion) can serve as a predictor of ventricular fibrillation during reperfusion (rVF) in patients with anterior STEMI undergoing primary PCI.METHODS AND RESULTS: Study population included consecutive patients with anterior infarct localization admitted for primary PCI (n = 181, age 65 [57; 76] years, 66% male). Of those, 14 patients had rVF (rVF group, age 59 [47; 76] years, 64% male) and patients without rVF comprised the No-rVF group (n = 167, age 65 [57; 76] years, 66% male). Association of TTWI with rVF was analyzed using logistic regression analysis adjusted for relevant clinical and electrocardiographic covariates. The prevalence of TTWI in rVF group was 62% comparing to 23% in the No-rVF group, p = 0.005. TTWI was associated with increased risk of rVF (OR 5.51; 95% CI 1.70-17.89; p = 0.004) and remained a significant predictor after adjustment for age, gender, history of MI prior to index admission, VF before reperfusion, Tpeak-Tend, maximal ST elevation, and QRS duration (OR 23.49; 95% CI 3.14-175.91; p = 0.002).CONCLUSIONS: The terminal T-wave inversion in anterior leads before PCI independently predicted rVF in patients with anterior MI thus confirming the previous experimental/simulation findings.
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| 5. |
- Silfverberg, Thomas, et al.
(författare)
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Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
- 2023
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Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ Publishing Group Ltd. - 0022-3050 .- 1468-330X.
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundA growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare.MethodsWe assessed 231 patients and the final analysis included 174 RRMS patients who were treated with aHSCT in Sweden before 1 January 2020. Efficacy was evaluated by performing a retrospective analysis of prospectively collected data from the Swedish MS registry. Procedure-related safety was assessed by analysing data from electronic patient records covering a period of 100 days following aHSCT.ResultsWith a median follow-up time of 5.5 (IQR: 3.4-7.5) years, the Kaplan-Meier estimate for no evidence of disease activity was 73% (95% CI 66% to 81%) at 5 years and 65% (95% CI 57% to 75%) at 10 years. Out of the 149 patients with baseline disability, 80 (54%) improved, 55 (37%) were stable and 14 (9%) deteriorated. The mean number of adverse events per patient was 1.7 (& PLUSMN;SD: 1.5) for grade 3 events and 0.06 (& PLUSMN;SD: 0.3) for grade 4 events. Febrile neutropenia was the most common adverse event, affecting 68% of patients. There was no treatment-related mortality.ConclusionsTreatment with aHSCT for RRMS is associated with freedom from disease activity in a majority of patients, with acceptable adverse events. This procedure should be considered a standard of care for patients with highly active RRMS.
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| 6. |
- Bilic, Damir, et al.
(författare)
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Detecting inconsistencies in annotated product line models
- 2020
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Ingår i: SPLC '20: Proceedings of the 24th ACM Conference on Systems and Software Product Line: Volume A. - New York, NY, USA : Association for Computing Machinery. - 9781450375696 ; , s. 252-262
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Konferensbidrag (refereegranskat)abstract
- Model-based product line engineering applies the reuse practices from product line engineering with graphical modeling for the specification of software intensive systems. Variability is usually described in separate variability models, while the implementation of the variable systems is specified in system models that use modeling languages such as SysML. Most of the SysML modeling tools with variability support, implement the annotation-based modeling approach. Annotated product line models tend to be error-prone since the modeler implicitly describes every possible variant in a single system model. To identifying variability-related inconsistencies, in this paper, we firstly define restrictions on the use of SysML for annotative modeling in order to avoid situations where resulting instances of the annotated model may contain ambiguous model constructs. Secondly, inter-feature constraints are extracted from the annotated model, based on relations between elements that are annotated with features. By analyzing the constraints, we can identify if the combined variability- and system model can result in incorrect or ambiguous instances. The evaluation of our prototype implementation shows the potential of our approach by identifying inconsistencies in the product line model of our industrial partner which went undetected through several iterations of the model.
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| 7. |
- Campeanu, Gabriel, et al.
(författare)
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Component-based development of embedded systems with GPUs
- 2020
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Ingår i: Journal of Systems and Software. - : Elsevier Inc.. - 0164-1212 .- 1873-1228. ; 161
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Tidskriftsartikel (refereegranskat)abstract
- One pressing challenge of many modern embedded systems is to successfully deal with the considerable amount of data that originates from the interaction with the environment. A recent solution comes from the use of GPUs, providing a significantly improved performance for data-parallel applications. Another trend in the embedded systems domain is component-based development. However, existing component-based approaches lack specific support to develop embedded systems with GPUs. As a result, components with GPU capability need to encapsulate all the required GPU information, leading to component specialization to specific platforms, hence drastically impeding component reusability. To facilitate component-based development of embedded systems with GPUs, we introduce the concept of flexible components. This increases the design flexibility by allowing the system developer to decide component allocation (i.e., either the CPU or GPU) at a later stage of the system development, with no change to the component implementation. Furthermore, we provide means to automatically generate code for adapting flexible components corresponding to their hardware placement, as well as code for component communication. Through the introduced support, components with GPU capability are platform-independent, and can be executed, without manual adjustment, on a large variety of hardware (i.e., platforms with different GPU characteristics).
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| 8. |
- Capannini, Gabriele, et al.
(författare)
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Reliable Visibility Algorithms for Emergency Stop Systems in Smart Industries
- 2022
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Ingår i: Proceedings - 2022 IEEE 46th Annual Computers, Software, and Applications Conference, COMPSAC 2022. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665488105 ; , s. 89-94
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Konferensbidrag (refereegranskat)abstract
- Automated machinery and robots working with humans are the norm in modern smart industries. A previous work in this area proposed a tool for improving the safety of such work places: an emergency system which halts those machines that are visible from an emergency stop button when it is pressed [1]. The solution presented in this paper improves the reliability of the aforementioned one at the expense of a higher computational complexity. Furthermore, two algorithmic optimizations are presented to mitigate the extra computational cost as it is shown by the results collected from the set of experiments conducted.
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| 9. |
- Capannini, Gabriele, et al.
(författare)
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Thou Shalt Not Move : A Visibility-based Emergency Stop System for Smart Industries
- 2021
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Ingår i: ACM International Conference Proceeding Series. - New York, NY, USA : Association for Computing Machinery. - 9781450390576
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Konferensbidrag (refereegranskat)abstract
- Nowadays, industries are crowded with automatized machinery and robots that interact with human operators. In addition to other safety measures already present, we propose a further tool to equip such working places with a visibility-based emergency stop system that only affects those machines that are visible from the position of an emergency stop button when it is pressed. This paper presents the realization of such a system and the preliminary results collected from the conducted scalability experiments.
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| 10. |
- De Greef, Julien, et al.
(författare)
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Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients : A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
- 2024
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Ingår i: Journal of Infection. - : Elsevier. - 0163-4453 .- 1532-2742. ; 88:6
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesNocardiosis is a rare but life-threatening infection after hematopoietic cell transplantation (HCT). We aimed at identifying risk factors for nocardiosis after allogeneic HCT and clarifying the effect of trimethoprim-sulfamethoxazole prophylaxis on its occurrence.MethodsWe performed a retrospective multicenter case-control study of patients diagnosed with nocardiosis after allogeneic HCT between January 2000 and December 2018. For each case, two controls were matched by center, transplant date, and age group. Multivariable analysis was conducted using conditional logistic regression to identify potential risk factors for nocardiosis. Kaplan-Meier survival curves of cases and controls were compared using log-rank tests.ResultsSixty-four cases and 128 controls were included. Nocardiosis occurred at a median of 9 months after allogeneic HCT (interquartile range: 5–18). After adjustment for potential confounders in a multivariable model, Nocardia infection was associated with tacrolimus use (adjusted odds ratio [aOR] 9.9, 95 % confidence interval [95 % CI]: 1.6–62.7), lymphocyte count < 500/µL (aOR 8.9, 95 % CI: 2.3–34.7), male sex (aOR 8.1, 95 % CI: 2.1–31.5), recent use of systemic corticosteroids (aOR 7.9, 95 % CI: 2.2–28.2), and recent CMV infection (aOR 4.3, 95 % CI: 1.2–15.9). Conversely, use of trimethoprim-sulfamethoxazole prophylaxis was associated with a significantly decreased risk of nocardiosis (aOR 0.2, 95 % CI: 0.1–0.8). HCT recipients who developed nocardiosis had a significantly decreased survival, as compared with controls (12-month survival: 58 % and 90 %, respectively; p < 0.0001).ConclusionsWe identified six factors independently associated with the occurrence of nocardiosis among allogeneic HCT recipients. In particular, trimethoprim-sulfamethoxazole prophylaxis was found to protect against nocardiosis.
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