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- Stenström, Mats, 1960-
(författare)
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Computerised Microtomography : Non-invasive imaging and analysis of biological samples, with special reference to monitoring development of osteoporosis in small animals
- 2001
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The use of Computerised microtomography (CμT) in biomedical research is well established, with most applications developed at synchrotron facilities. The possibility to non-invasively monitor morphological changes in biological samples, makes it an attractive technique in biomedicine. However, high absorbed doses and long examination times are a disadvantage that limits the possibilities of performing longitudinal examinations.The aim of this work was to optimise CmT using conventional X-ray tubes for applications in non-destructive material testing and for skeleton research in small animals (rat). A calculational model of the imaging system was developed and used to optimise the relation between image quality, expressed as the signal-to-noise ratio (SNR) in detecting a contrasting detail, and imaging time in material testing. The model was modified to optimise the relation between the SNR in detecting a trabecular detail in cancelleous bone and the mean absorbed dose in spongiosa and skin for (rat) tibia and femur.Gastrectomized Sprague-Dawley rats were used to initiate osteoporotic changes. In order to detect differences in between gastrectomized rats and controls, spatial resolutions of 150 mm or better were needed. The minimum absorbed doses in femur spongiosa at SNR = 5 were 1mGy - 700 mGy at spatial resolutions from 100 mm to10 mm. In femur skin, the corresponding minimum absorbed doses were 2 mGy - 2000 mGy. Corresponding values for tibia were 0.3 mGy - 300 mGy for both spongiosa and skin (spatial resolution of 100 mm to10 mm). Taking 0.5 Gy as the tolerance limit for the spongiosa dose, longitudinal studies with six repeated examinations will be possible at a spatial resolution of 25 mm in femur and 17 examinations in tibia.
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| 2. |
- Alm Carlsson, Gudrun
(författare)
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Bragg-Gray Dosimetry : Theory of Burch
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The theoretical approach to Bragg-Gray dosimetry is: a Bragg-Gray cavity is a cavity (detector) so small that, when inserted into a medium, it does not disturb the fluence of charged particles existing in the medium. This means that the ideal Bragg-Gray cavity (detector) is one of infinitesimal dimensions, a "point" detector. In practice, such detectors do not exist but many real detectors may, in a first approximation, be treated as Bragg-Gray detectors to a high degree of accuracy. Corrections needed (so called perturbation corrections) to account for the deviation of the signal from a practical detector from that of an ideal one has been treated by, e.g., ICRU 1984, Alm Carlsson, 1985, Svensson and Brahme 1986, Alm Carlsson 1987. Derivation of "perturbation corrections" needs careful consideration and under-standing of the ideal case, i.e., that from which deviations are to be corrected for. The ideal case of a Bragg-Gray detector has been treated by Bragg 1912, Gray 1936, Laurence 1937, Spencer and Attix 1955 and Burch 1955. The formulation of Bragg-Gray theory by Spencer and Attix has found wide practical application and has been treated in detail elsewhere. The theory of Burch treats the same problem as did Spencer and Attix, viz., the significance of generation and slowing down of delta-particles in both medium and detector. Burch treated the problem in considerable detail but didn't find a solution for practical calculations. From a physical point of view, however, there is much to learn from Burch's approach. Also, his treatment of so called track ends, evaluated in some detail by Burch 1957, has been adapted in later versions of the Spencer-Attix formulation of Bragg-Gray theory.
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| 3. |
- Alm Carlsson, Gudrun
(författare)
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Fanos Teorem
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I ett oändligt medium erhålles en fullt uppbyggd fluens i alla punkter av mediet. I ett ändligt medium erhålles inte full uppbyggnad av fluensen på avstånd mindre än en maximal "partikelräckvidd" från begränsningsytorna. Fanos teorem har visats gälla för alla punkter i ett oändligt medium men kan endast gälla i det inre av ett ändligt medium där förhållandena är ekvivalenta med dem i det oändliga mediet.
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| 4. |
- Alm Carlsson, Gudrun
(författare)
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Spencer-Attix Cavity Theory
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The cavity theory by Spencer and Attix treats the energy deposition in a Bragg-Gray (B-G) cavity (detector). Originally the theory was developed for the case of a B-G detector inside a medium irradiated with photons and assuming electronic equilibrium in the medium at the position of the cavity. The theory is also applicable in media irradiated with other types of uncharged ionizing particles (e.g., neutrons) and charged particles such as electrons and protons. The special case of photon irradiation under CPE (charged particle equilibrium) conditions was coupled to a model for calculating the energy spectrum of the equilibrium fluence of electrons in the undisturbed medium. For other situations, e.g., in a medium externally irradiated with electrons, the problem is to evaluate the energy spectrum of the electron fluence at the point considered in the medium. Today, this is mostly accomplished using Monte Carlo simulations. A Bragg-Gray cavity is regarded to be so small that: the energy imparted to the cavity from electrons released by photons in the cavity is negligible compared to the energy imparted from electrons released by photons in the surrounding medium and passing through the cavity the cavity should not disturb the fluence of electrons in the medium, i. e., the fluence of electrons traversing the cavity is assumed to be identical to that existing at the point of interest in the medium in the absence of the cavity.
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| 5. |
- Alm Carlsson, Gudrun
(författare)
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Spencer-Attix kavitetsteori
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Spencer-Attix kavitetsteori behandlar energideponeringen i en Bragg-Gray kavitet (detektor) inuti ett medium bestrålat med fotoner och med elektronjämvikt i mediet på kavitetens plats. Med en Bragg-Gray kavitet menas en kavitet så liten att energideponeringen i kaviteten från elektroner frigjorda av fotoner i kaviteten är försumbar jämfört med energideponeringen från elektroner frigjorda av fotoner i omgivande mediet och som passerar in kaviteten kaviteten skall inte nämnvärt störa fluensen av elektronerna i mediet, dvs kaviteten antas i varje punkt genomkorsad av samma fluens av elektroner, som finns i mediet i frånvaro av kaviteten
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| 6. |
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| 7. |
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| 8. |
- Dance, David, et al.
(författare)
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Influence of anode/filter material and tube potential on contrast, signal-to-noise ratio and average absorbed dose in mammography: a Monte Carlo study
- 2000
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Ingår i: British Journal of Radiology. - 0007-1285. ; 73, s. 1056-1067
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Tidskriftsartikel (refereegranskat)abstract
- The comparative performance of mammographic X-ray systems that use different anode/filter combinations has been assessed for screen±®lm and digital imaging. Monte Carlo techniques have been used to calculate average glandular dose as well as contrast and signal-tonoise ratio for imaging two test details. Five anode/filter combinations have been studied to establish the potential for dose saving or image quality improvement. For screen±film mammography, it was found that little bene®t is gained by changing from a standard 28 kV molybdenum/molybdenum spectrum for breasts up to 6 cm thick. For thicker breasts, where the tube potential for the standard technique might be increased, 20% improvement in contrast can be achieved without dose penalty using molybdenum/rhodium or rhodium/rhodium spectra, whereas dose savings of more than 50% can be attained whilst maintaining contrast using tungsten/rhodium or rhodium/aluminium spectra. In digital mammography, a molybdenum/ molybdenum spectrum delivers the lowest dose for a 2 cm breast, but gives the highest dose for thicker breasts. Tungsten/rhodium or rhodium/aluminium spectra provide the lowest doses at greater thicknesses. It is concluded that for screen±film mammography, molybdenum/ molybdenum is the spectrum of choice for all but the thickest or most glandular breasts. In digital mammography, an alternative spectrum is preferable for breasts thicker than 2 cm.
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| 9. |
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| 10. |
- Hedtjärn, Håkan, 1964-, et al.
(författare)
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Accelerated Monte Carlo-based dose calculations for brachytherapy planning using correlated sampling.
- 2000
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Ingår i: Digest of papers of the 2000 world congress on medical physics. CD-Rom Chicago July 23-28,2000. - : IEEE. - 0780364651 ; , s. 372-375 vol. 1
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Konferensbidrag (refereegranskat)abstract
- Correlated sampling is evaluated as a strategy for accelerating Monte Carlo photon transport (MCPT) simulation for use as a practical patient-specific treatment-planning tool. Correlated MCPT simulation was shown to offer substantial efficiency gains over conventional MCPT simulation for selected parts of the 3D volume but was not sufficient to improve MCPT simulation everywhere
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