| 1. |
- Andreasson, Patrik, et al.
(författare)
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BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
- 1997
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Ingår i: Genes, Chromosomes and Cancer. - 1045-2257. ; 20:3, s. 299-304
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Tidskriftsartikel (refereegranskat)abstract
- A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
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| 2. |
- Brånemark, Rickard, 1960, et al.
(författare)
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Biomechanical characterization of osseointegration: an experimental in vivo investigation in the beagle dog.
- 1998
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Ingår i: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. - : Wiley. - 0736-0266. ; 16:1, s. 61-9
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Tidskriftsartikel (refereegranskat)abstract
- This study reports the results of torsion tests, pull-out tests, and lateral loading tests on osseointegrated commercially pure titanium fixtures. The tests were performed in vivo on six beagle dogs. Three fixtures, each with a diameter of 3.7 mm, were installed bilaterally in the tibia of each animal. The mean maximal pull-out load was 1.55 kN (n = 4), the mean maximal lateral transverse load was 0.21 kN (n = 2), the mean maximal lateral axial load was 0.18 kN (n = 2), the mean breakpoint torque was 0.31 Nm (n = 3), and the mean maximal torque was 0.43 Nm (n = 3). The torsion test revealed an almost immediate plastic deformation of the interface between the implant and bone; this indicates that although the contact between the bone and the implant is close, there is no strong bond, at least not in shear. The major transfer of load from the implant to the surrounding bone tissue must therefore depend on the design of the implant. A histological evaluation with measurements of the amount of bone in contact with the fixtures was performed. By the use of the histological and mechanical data, it is possible to estimate shear stresses in bone tissue (pull-out test) and in the interface (torque test). The mean maximal shear stress in bone tissue in the pull-out tests was 100 MPa (n = 4); the mean shear stress in the interface was 4.3 MPa (n = 3) in the torsion tests at the breakpoint torque and was 6.0 MPa (n = 3) at the maximal torque. It was also possible to estimate the shear modulus of elasticity in the pull-out and torque tests. The mean shear modulus in pull-out was 119 MPa (n = 4), and the mean apparent shear modulus in torsion was 9 kPa (n = 3) for an assumed interface thickness of 100 nm and was 86 kPa (n = 3) for an assumed interface thickness of 1,000 nm.
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| 3. |
- Lundberg, Ingvar, 1934, et al.
(författare)
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Självmedvetande
- 1995
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Ingår i: Nationalencyklopedin, 1:a uppl., Band 16. - Höganäs : Bra Böcker. - 917024619X
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Bokkapitel (refereegranskat)
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| 4. |
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