| 1. |
- Borga, Magnus, et al.
(författare)
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A Survey of Current Techniques for Reinforcement Learning
- 1992
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This survey considers response generating systems that improve their behaviour using reinforcement learning. The difference between unsupervised learning, supervised learning, and reinforcement learning is described. Two general problems concerning learning systems are presented; the credit assignment problem and the problem of perceptual aliasing. Notations and some general issues concerning reinforcement learning systems are presented. Reinforcement learning systems are further divided into two main classes; memory mapping and projective mapping systems. Each of these classes is described and some examples are presented. Some other approaches are mentioned that do not fit into the two main classes. Finally some issues not covered by the surveyed articles are discussed, and some comments on the subject are made.
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| 2. |
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| 3. |
- Danielsson, L, et al.
(författare)
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Human monoclonal antibodies with different fine-specificity for digoxin derivatives: Cloning of heavy and light chain variable region sequences
- 1991
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Ingår i: Immunology. - 0019-2805. ; 74:1, s. 50-54
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Tidskriftsartikel (refereegranskat)abstract
- Human-mouse hybridoma cell lines producing human monoclonal antibodies against the cardiac glycoside digoxin were established after in vitro immunization or direct immortalization of human peripheral blood lymphocytes with digoxin. Three antibodies, designated M06, LH92 and LH 1 14, displayed different patterns of fine specificity against digoxin and several digoxin analogues, as elucidated by inhibition ELISA. All three monoclonal antibodies had p heavy chains, two of them (M06 and LH 114) had K light chains and one (LH92) A light chains. DNA encoding the variable regions of both heavy and light chains of the three antibodies were amplified from cDNA using the polymerase chain reaction (PCR). The nucleotide sequences of the amplified DNA were determined after subcloning of PCR fragments in M13 vectors. The deduced amino acid sequences revealed considerable sequence differences in the complementarity determining regions between the three antibodies.
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| 4. |
- Hakeberg, Magnus, 1954, et al.
(författare)
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A 10-year follow-up of patients treated for dental fear.
- 1990
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Ingår i: Scandinavian journal of dental research. - 0029-845X. ; 98:1, s. 53-9
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Tidskriftsartikel (refereegranskat)abstract
- Different types of treatment have been used in trying to reduce dental anxiety in adult patients with severe fear and avoidance behavior. However, there is an obvious shortage in long-term treatment follow-up. The present investigation reports results over a period of 10 yr of 14 patients treated for dental fear in a specialized dental fear treatment and research clinic. The aims of this project were to evaluate patients' regularity in dental behavior between 1977 and 1987, changes in and present level of dental fear and other long-standing positive/negative effects of the respective initial treatments. The 14 dental phobic patients were assigned to two treatment groups, one receiving Systematic Desensitization and one Premedication with valium before dental treatment. Pre- and posttreatment status as well as the 10-yr follow-up were evaluated by psychometric (Corah's Dental Anxiety Scale and a Mood Adjective Checklist) and physiological (Skin Conductance Response) measurements. A majority of patients (100% SD, 63% P) reported regular dental care during the period 1977-87. Positive side-effects were reported by seven patients. A significant reduction of dental fear (DAS) was found with a better effect for the SD-group. This was paralleled by a rise in mood (MACL). The SCR figures were non-significant. In conclusion, the results revealed long-standing effects with regard to a high degree of regular dental care and reduction of dental fear. In addition, positive side-effects were reported.
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| 5. |
- Hakeberg, Magnus, 1954, et al.
(författare)
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Long-term effects on dental care behavior and dental health after treatments for dental fear.
- 1993
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Ingår i: Anesthesia progress. - 0003-3006 .- 1878-7177. ; 40:3, s. 72-7
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Tidskriftsartikel (refereegranskat)abstract
- Three different treatments for dental fear were tested in a long-term perspective study. Twenty-nine patients with severe dental anxiety and avoidance behavior were assigned to Behavioral Therapy (BT, n = 12), PRemedication with bensodiazepine (PR, n = 8) or dental treatment under General Anesthesia (GA, n = 9). Ten years after initial treatment the patients were reexamined. Changes in dental anxiety and dental care attendance were reported. Patients' dental health status was assessed by radiographic survey. Regular dental attendance was reported by 19 patients (65.5%), with a significantly better result for the BT group (91.6%) compared to the GA group (33.3%). Reported level of dental anxiety, as measured by the Dental Anxiety Scale, revealed a significant reduction during the 10-yr period except among GA patients and those reporting irregular dental attendance behavior. A rise in mood as assessed by the Mood Adjective Checklist was revealed in the total group, with a better effect in the BT and PR groups as well as in patients who reported regular dental attendance. A substantial general improvement in oral health was seen during the 10-yr period, especially among patients receiving regular dental care. Thus, for a majority of patients in this study, directed treatment for dental anxiety and avoidance behavior made it possible to maintain regular dental care behavior during a 10-yr period.
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| 6. |
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| 7. |
- Hakeberg, Magnus, 1954, et al.
(författare)
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Prevalence of dental anxiety in an adult population in a major urban area in Sweden.
- 1992
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Ingår i: Community dentistry and oral epidemiology. - 0301-5661 .- 1600-0528. ; 20:2, s. 97-101
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Tidskriftsartikel (refereegranskat)abstract
- The aims of the study were to describe the level of dental anxiety in a representative sample of an adult population, to evaluate different demographic variables in relation to dental anxiety, and to compare two measurement scales of dental anxiety. A random sample of residents (n = 830) of the city of Gothenburg (population 432,000) was selected for a telephone survey. The survey comprised different questions concerning demographic variables, dental care habits, and the level of dental anxiety. The methods of measurement of dental anxiety were a 10-point dental Fear Scale (FS) and the Corah Dental Anxiety Scale (DAS). A total of 620 interviews were completed giving a response rate of 74.7%. 41.4% of the respondents were males, 58.6% females. Females were significantly more likely to report a high dental anxiety compared with males. The prevalence of high dental anxiety in the sample as measured by the FS and DAS was 6.7% and 5.4% respectively. The correlation between the FS and DAS was 0.81. The distribution of high dental anxiety and age showed a clearly and significantly higher portion of dental anxiety in the age group 20-39 yr compared to both younger and older groups. The effect of dental anxiety on regularity of dental visits revealed a significant difference as measured by the FS. No significant correlation was found between dental anxiety and educational level or income. A majority of the respondents (82-95%) expressed a desire for establishment of a special dental fear treatment clinic without need for referral.
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| 9. |
- Sandberg, Ann-Sofie, et al.
(författare)
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Alginate, small bowel sterol excretion, and absorption of nutrients in ileostomy subjects
- 1994
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Ingår i: American Journal of Clinical Nutrition. - 0002-9165 .- 1938-3207. ; 60:5, s. 751-756
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Tidskriftsartikel (refereegranskat)abstract
- The effect of alginate on ileostomy excretion of sterols and nutrients was investigated in six ileostomy subjects fed a constant low-fiber diet with or without supplementation with 7.5 g sodium alginate. A mean of 95% of uronic acids derived from the sodium alginate was recovered in the ileostomy contents. Supplementation with alginate increased fat excretion by 140% and decreased bile acids excretion by 12%. Sodium and potassium excretion were significantly increased whereas starch and nitrogen excretion were unchanged. Five of six subjects showed a decreased apparent absorption of iron and manganese with alginate, which, however, was not statistically significant. Absorption of phosphorus, calcium, magnesium, and zinc were unchanged. Almost no digestion of sodium alginate occurs in the stomach and small intestine. The increased fatty acids excretion may be explained by the binding or trapping of fatty acids in the gel matrix formed by alginate, which may also cause a reduced bile flow.
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