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- CARLSTEN, S, et al.
(författare)
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RADAR TECHNIQUES FOR INDICATING INTERNAL EROSION IN EMBANKMENT DAMS
- 1995
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Ingår i: JOURNAL OF APPLIED GEOPHYSICS. - : ELSEVIER SCIENCE BV. - 0926-9851. ; 33:1-3, s. 143-156
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- For improved dam safety in Sweden, radar techniques have been tested for detecting anomalous zones in the central core of embankment dams and the level of the core crest. Anomalies in the core may indicate a continuing process and a greater risk of intern
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- Jonsson, Charlotte A, 1971, et al.
(författare)
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Mycophenolate mofetil ameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr mice.
- 1999
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Ingår i: Cellular immunology. - : Elsevier BV. - 0008-8749. ; 197:2, s. 136-44
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Tidskriftsartikel (refereegranskat)abstract
- Effects on T lymphocyte mediated pathology, phenotypes, and functions in MRLlpr/lpr mice given mycophenolate mofetil (MMF) (100 mg/kg/day) via drinking water or controls given ip cyclophosphamide (CYC) injections (1.8 mg/mouse/week) or water were described. Both MMF and CYC treatment diminished kidney and large salivary gland perivascular cell infiltrates, reduced profoundly double-negative (DN) T cell frequencies, decreased total lymphocyte number in spleen, and increased in vitro proliferative response to Con A. IFN-gamma and IL-10 in supernatants from Con A stimulated spleen cells were augmented after MMF but not CYC treatment. MMF treatment increased whereas CYC reduced IL-12 in serum. Kidney expressions of IFN-gamma, IL-10, and IL-12 mRNA were unaffected by MMF but decreased by CYC. Our results demonstrate that MMF and CYC suppress perivascular T lymphocyte inflammation by reducing the DN T cell population and by amelioration of T cell function. The varying cytokine patterns suggest different mechanisms of the two drugs.
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