SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Carrell David S.) srt2:(2018)"

Sökning: WFRF:(Carrell David S.) > (2018)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Mosley, Jonathan D., et al. (författare)
  • Probing the Virtual Proteome to Identify Novel Disease Biomarkers
  • 2018
  • Ingår i: Circulation. - 1524-4539. ; 138:22, s. 2469-2481
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predicted protein levels to clinical diagnoses in >40 000 individuals. METHODS: We used genome-wide association data from the Framingham Heart Study (n=759) to construct genetic predictors for 1129 plasma protein levels. We validated the genetic predictors for 268 proteins and used them to compute predicted protein levels in 41 288 genotyped individuals in the Electronic Medical Records and Genomics (eMERGE) cohort. We tested associations for each predicted protein with 1128 clinical phenotypes. Lead associations were validated with directly measured protein levels and either low-density lipoprotein cholesterol or subclinical atherosclerosis in the MDCS (Malmö Diet and Cancer Study; n=651). RESULTS: In the virtual proteomic analysis in eMERGE, 55 proteins were associated with 89 distinct diagnoses at a false discovery rate q<0.1. Among these, 13 associations involved lipid (n=7) or atherosclerosis (n=6) phenotypes. We tested each association for validation in MDCS using directly measured protein levels. At Bonferroni-adjusted significance thresholds, levels of apolipoprotein E isoforms were associated with hyperlipidemia, and circulating C-type lectin domain family 1 member B and platelet-derived growth factor receptor-β predicted subclinical atherosclerosis. Odds ratios for carotid atherosclerosis were 1.31 (95% CI, 1.08-1.58; P=0.006) per 1-SD increment in C-type lectin domain family 1 member B and 0.79 (0.66-0.94; P=0.008) per 1-SD increment in platelet-derived growth factor receptor-β. CONCLUSIONS: We demonstrate a biomarker discovery paradigm to identify candidate biomarkers of cardiovascular and other diseases.
  •  
2.
  • Weston, David J., et al. (författare)
  • The Sphagnome Project : enabling ecological and evolutionary insights through a genus-level sequencing project
  • 2018
  • Ingår i: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 217:1, s. 16-25
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Considerable progress has been made in ecological and evolutionary genetics with studies demonstrating how genes underlying plant and microbial traits can influence adaptation and even 'extend' to influence community structure and ecosystem level processes. Progress in this area is limited to model systems with deep genetic and genomic resources that often have negligible ecological impact or interest. Thus, important linkages between genetic adaptations and their consequences at organismal and ecological scales are often lacking. Here we introduce the Sphagnome Project, which incorporates genomics into a long-running history of Sphagnum research that has documented unparalleled contributions to peatland ecology, carbon sequestration, biogeochemistry, microbiome research, niche construction, and ecosystem engineering. The Sphagnome Project encompasses a genus-level sequencing effort that represents a new type of model system driven not only by genetic tractability, but by ecologically relevant questions and hypotheses.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (1)
refereegranskat (1)
Författare/redaktör
Turetsky, Merritt R. (1)
Benscoter, Brian W. (1)
Dorrepaal, Ellen (1)
Nilsson, Mats (1)
Melander, Olle (1)
Smith, J Gustav (1)
visa fler...
Norby, Richard J. (1)
Vasan, Ramachandran ... (1)
Roden, Dan M. (1)
Jarvik, Gail P. (1)
Gerszten, Robert E. (1)
Rydin, Håkan, 1953- (1)
Limpens, Juul (1)
Shaw, A. Jonathan (1)
Wang, Thomas J (1)
Rice, Steven K. (1)
Stenoien, Hans K. (1)
Tuittila, Eeva-Stiin ... (1)
Granath, Gustaf (1)
Yang, Qiong (1)
Schmutz, Jeremy (1)
Euskirchen, Eugénie ... (1)
Williams, Marc S. (1)
Mentch, Frank D (1)
Kiryluk, Krzysztof (1)
McCarty, Catherine A ... (1)
Crosslin, David R. (1)
Mosley, Jonathan D (1)
Shaffer, Christian M ... (1)
Carrell, David S. (1)
Larson, Eric B. (1)
Jacobson, Daniel (1)
Ritchie, Marylyn D. (1)
Ferguson, Jane F (1)
Verma, Shefali S. (1)
Kullo, Iftikhar J. (1)
Peissig, Peggy L. (1)
Pacheco, Jennifer A. (1)
Weston, David J. (1)
Namjou, Bahram (1)
Karlson, Elizabeth W ... (1)
Jackson, Michelle (1)
Gordon, Adam S. (1)
Borthwick, Kenneth M ... (1)
Denny, Josh C. (1)
Ranjan, Priya (1)
Ullrich, Kristian K. (1)
Muchero, Wellington (1)
Szovenyi, Peter (1)
Sleiman, Patrick M. (1)
visa färre...
Lärosäte
Umeå universitet (1)
Uppsala universitet (1)
Lunds universitet (1)
Sveriges Lantbruksuniversitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)
Lantbruksvetenskap (1)
År
2018 (2)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy