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Träfflista för sökning "WFRF:(Chang Shu Hao) srt2:(2016)"

Sökning: WFRF:(Chang Shu Hao) > (2016)

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  • Lee, Jin-Ching, et al. (författare)
  • Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki
  • 2016
  • Ingår i: Marine Drugs. - : MDPI AG. - 1660-3397 .- 1660-3397. ; 14:8
  • Tidskriftsartikel (refereegranskat)abstract
    • A new marine ecdysteroid with an alpha-hydroxy group attaching at C-4 instead of attaching at C-2 and C-3, named palythone A (1), together with eight known compounds (2-9) were obtained from the ethanolic extract of the Formosan zoanthid Palythoa mutuki. The structures of those compounds were mainly determined by NMR spectroscopic data analyses. The absolute configuration of 1 was further confirmed by comparing experimental and calculated circular dichroism (CD) spectra. Anti-dengue virus 2 activity and cytotoxicity of five isolated compounds were evaluated using virus infectious system and [3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assays, respectively. As a result, peridinin (9) exhibited strong antiviral activity (IC50 = 4.50 +/- 0.46 mu g/mL), which is better than that of the positive control, 2'CMC. It is the first carotene-like substance possessing anti-dengue virus activity. In addition, the structural diversity and bioactivity of the isolates were compared by using a ChemGPS-NP computational analysis. The ChemGPS-NP data suggested natural products with anti-dengue virus activity locate closely in the chemical space.
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