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- Jiang, Xuehe, et al.
(författare)
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Multifunctional Cellulose Nanofibrils-GdF3 Nanoparticles Hybrid Gel and Its Potential Uses for Drug Delivery and Magnetic Resonance Imaging
- 2023
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Ingår i: ACS Applied Nano Materials. - : American Chemical Society (ACS). - 2574-0970. ; 6:22, s. 21182-21193
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Tidskriftsartikel (refereegranskat)abstract
- A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF3 NPs) via Cu0-mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF3 NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF3-PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF3 NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF3-PSA-CNF). The nanostructures of GdF3 NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF3 nanoparticles, properties for magnetic resonance imaging (MRI) of GdF3-PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
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| 2. |
- Lerouge, Frederic, et al.
(författare)
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In vivo targeting and multimodal imaging of cerebral amyloid-beta aggregates using hybrid GdF3 nanoparticles
- 2022
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Ingår i: Nanomedicine. - : FUTURE MEDICINE LTD. - 1743-5889 .- 1748-6963. ; 17:29, s. 2173-2187
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To propose a new multimodal imaging agent targeting amyloid-beta (A beta) plaques in Alzheimers disease. Materials & methods: A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimers disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging. Results & conclusion: Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution. In vivo brain uptake was dependent on the blood-brain barrier status. Nevertheless, multimodal imaging showed successful A beta targeting in both transgenic mice and A beta fibril-injected rats.
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