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- Fawole, Henrietta O., et al.
(författare)
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Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis : The MOST Study
- 2020
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Ingår i: International Journal of Rheumatic Diseases. - 1756-1841. ; 23:4, s. 559-568
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA). Methods: A longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2-year follow-up. Participants self-reported fatigue at baseline for the first time in the MOST cohort and at follow-up using a 0-10 visual analog scale. At baseline, questionnaires on sociodemographics, disease-related symptoms, physical and mental health factors were completed. Data were analyzed using linear regressions with a backwards elimination approach. Results: Of the 2330 individuals in the MOST cohort at baseline, 576 had symptomatic knee OA and of these, 449 with complete fatigue values at baseline and follow-up were included in this analysis. Minimally important fatigue change (ie, worsening [≥1.13], no change [<0.82 or <1.13] and improvement [≥−0.82]) from baseline to follow-up were unequal within the population (34.5%, 26.9%, 38.5%; χ2 [2, N = 449] = 9.32, P =.009). The multiple linear regression showed that baseline fatigue (unstandardized coefficient [Β] = 0.435; 95% confidence interval [CI] 0.348-0.523, P <.001), slow gait speed (Β = −1.124; 95% CI −1.962 to −0.285, P =.009), depressive symptoms (Β = 0.049; 95% CI 0.024-0.075, P <.001) and higher numbers of comorbidities (Β = 0.242; 95% CI 0.045-0.439, P =.016) were significant predictors of greater fatigue at follow-up. Conclusion: Fatigue is strongly associated with physical- and mental-related health factors. Individualized treatments that include combined psychological and physical function rehabilitation might be modalities for fatigue management.
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| 2. |
- Fawole, Henrietta O., et al.
(författare)
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Temporal associations between physical activity, mental activity and fatigue dimensions in knee osteoarthritis : an exploratory intensive longitudinal study
- 2020
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Ingår i: Fatigue: Biomedicine, Health and Behavior. - : Informa UK Limited. - 2164-1846 .- 2164-1862. ; 8:1, s. 32-48
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Tidskriftsartikel (refereegranskat)abstract
- Background: Fatigue may include both physical and mental dimensions. Evidence suggests that physical and mental activity may influence fatigue in knee osteoarthritis (OA). However, how physical and mental activities relate to fatigue dimensions in knee OA is unclear. Purpose: This study estimated intra-day contributions of physical and mental fatigue to general fatigue and evaluated temporal associations between physical activity, mental activity and fatigue dimensions in knee OA. Methods: An intensive longitudinal study combined with ecological momentary assessment of mental activity intensity and fatigue dimensions was conducted on 23 participants with knee OA. Physical activity was monitored continuously with an accelerometer over 7 days. Results: Physical fatigue contributed 33% more to general fatigue earlier in the day than mental fatigue, and 11% more near the end of the day. Within-day, previous general fatigue significantly and negatively predicted: future step counts, light intensity physical activity time, and light intensity physical activity + standing time. We found a significant bidirectional association between mental activity and general fatigue, a positive association between mental activity and mental fatigue and a significant negative association between mental fatigue and mental activity. Conclusion: Within-day general fatigue may be a significant fatigue dimension that reduces physical activity. Conversely there was no evidence that physical activity might contribute to lower scores on any fatigue dimensions in this population. To manage general fatigue, physical and mental fatigue might have to be targeted more precisely at different time of the day.
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| 3. |
- Giné-Garriga, Maria, et al.
(författare)
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A Pilot Randomised Clinical Trial of a Novel Approach to Reduce Sedentary Behaviour in Care Home Residents : Feasibility and Preliminary Effects of the GET READY Study
- 2020
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:8
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Tidskriftsartikel (refereegranskat)abstract
- Care-home residents are among the most sedentary and least active of the population. We aimed to assess the feasibility, acceptability, safety, and preliminary effects of an intervention to reduce sedentary behaviour (SB) co-created with care home residents, staff, family members, and policymakers within a pilot two-armed pragmatic cluster randomized clinical trial (RCT). Four care homes from two European countries participated, and were randomly assigned to control (usual care, CG) or the Get Ready intervention (GR), delivered by a staff champion one-to-one with the care home resident and a family member. A total of thirty-one residents participated (51.6% female, 82.9 (13.6) years old). GR involves six face to face sessions over a 12-week period with goal-oriented prompts for movement throughout. The feasibility and acceptability of the intervention were assessed and adverse events (AEs) were collected. The preliminary effects of the GR on SB, quality of life, fear of falling, and physical function were assessed. Means and standard deviations are presented, with the mean change from baseline to post-intervention calculated along with 95% confidence intervals. The CG smoked more, sat more, and had more functional movement difficulties than the GR at baseline. The GR intervention was feasible and acceptable to residents and staff. No AEs occurred during the intervention. GR participants showed a decrease in daily hours spent sitting/lying (Cohen's d = 0.36) and an increase in daily hours stepping, and improvements in health-related quality of life, fear of falling, and habitual gait speed compared to usual care, but these effects need confirmation in a definitive RCT. The co-created GR was shown to be feasible and acceptable, with no AEs.
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| 4. |
- Stamatakis, Emmanuel, et al.
(författare)
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Emerging collaborative research platforms for the next generation of physical activity, sleep and exercise medicine guidelines : the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS)
- 2020
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Ingår i: British Journal of Sports Medicine. - : BMJ. - 0306-3674 .- 1473-0480. ; 54:8, s. 435-437
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Galileo Galilei’s quote ‘measure what is measurable, and make measurable what is not so’ has particular relevance to health behaviours, such as physical activity (PA), sitting and sleep, whose measurement during free living is notoriously difficult. To date, much of what we know about how these behaviours affect our health is based on self-report by questionnaires which have limited validity, are prone to bias and inquire about selective aspects of these behaviours. Although self-reported evidence has made great contributions to shaping public health and exercise medicine policy and guidelines until now,1 the ongoing advancements of accelerometry-based measurement and evidence synthesis methods are set to change the landscape. The aim of this editorial is to outline new directions in PA and sleep-related epidemiology that open new horizons for guideline development and improvement; and to describe a new research collaboration platform: the Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS).
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