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- Tabassum, R, et al.
(författare)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
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Tidskriftsartikel (refereegranskat)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 2. |
- Christiansen, J. S., et al.
(författare)
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Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations
- 2016
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Ingår i: European Journal of Endocrinology. - : Oxford University Press (OUP). - 0804-4643 .- 1479-683X. ; 174:6
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). Participants: A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists, regulatory scientists, and participants from the pharmaceutical industry. Evidence: Current literature was reviewed for gaps in knowledge. Expert opinion was used to suggest studies required to address potential safety and efficacy issues. Consensus process: Following plenary presentations summarizing the literature, breakout groups discussed questions framed by the planning committee. Attendees reconvened after each breakout session to share group reports. A writing team compiled the breakout session reports into a draft document that was discussed and revised in an open forum on the concluding day. This was edited further and then circulated to attendees from academic institutions for review after the meeting. Participants from pharmaceutical companies did not participate in the planning, writing, or in the discussions and text revision on the final day of the workshop. Scientists from industry and regulatory agencies reviewed the manuscript to identify any factual errors. Conclusions: LAGH compounds may represent an advance over daily GH injections because of increased convenience and differing phamacodynamic properties, providing the potential for improved adherence and outcomes. Better methods to assess adherence must be developed and validated. Long-term surveillance registries that include assessment of efficacy, cost-benefit, disease burden, quality of life, and safety are essential for understanding the impact of sustained exposure to LAGH preparations.
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| 7. |
- Schmidt, M., et al.
(författare)
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Diversity, distribution and preliminary conservation status of the flora of Burkina Faso
- 2017
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Ingår i: Phytotaxa. - : Magnolia Press. - 1179-3155 .- 1179-3163. ; 304:1, s. 1-215
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Tidskriftsartikel (refereegranskat)abstract
- West Africa is a floristically understudied region that is facing severe environmental changes in the 21 st century. Basic distribution data and information on the conservation status for most plant species of the region are scarce, and good information only exists for small areas of interest or for key species. This lack of knowledge seriously hampers urgently needed regional conservation efforts. Here we present comprehensive distribution information and preliminary, automated species conservation assessments for the flora of Burkina Faso, a country in tropical West Africa with a flora and vegetation typical for the savanna belt of the region. We documented and analysed the distribution of 1,568 species or 80% of the flora of Burkina Faso based on an expert curated dataset comprising ca. 150,000 occurrence records from herbarium specimens and vegetation surveys. We used this dataset and environmental niche models to calculate three indicator variables for a preliminary, automated conservation assessment. We classified 350 species (18% of the flora, excluding introduced species) as potentially "Critically Endangered", "Endangered", "Vulnerable" or "Near-Threatened" on the national level. The analyses confirmed species-rich areas in the south-west and south-east of the country, and showed a particular concentration of potentially Endangered species in the south. Furthermore, the proportion of potentially Endangered species differed between plant families, growth forms and habitats. Our results set the base for further plant geographical and ecological studies and are a data-driven baseline for further conservation assessments and large scale conservation strategies of the West African flora.
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