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- Chen, J., et al.
(författare)
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Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells
- 1994
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Ingår i: Immunity. - : Cell Press. - 1074-7613 .- 1097-4180. ; 1:1, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells resulted in normal levels of proliferation and immunoglobulin secretion. Likewise, stimulation of c-jun-/- T cells resulted in essentially normal levels of IL-2R alpha expression, IL-2 secretion, and proliferation. We further showed that the relatively normal activation responses of the c-jun-/- T cells probably results from the fact that other members of the Jun family contribute to the bulk of the activator protein-1 (AP-1) complexes in normal T cells and, as a result, AP-1 complexes are found at relatively normal levels in c-jun-/- T cells.
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- Szymanski, J. J., et al.
(författare)
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MEGA : A search for the decay mu –> e gamma
- 1994
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Ingår i: Intersections between particle and nuclear physics. Proceedings, 5th Conference, St. Petersburg, USA, May 31-June 6, 1994. ; , s. 789-792
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Konferensbidrag (refereegranskat)
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4. |
- Chen, F., et al.
(författare)
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Evaluation of a workstation for letter sorting in the Beijing post office
- 1993
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Ingår i: Occupational and environmental economics. - : Indian Society of Ergonomics.. - 819005080X ; , s. 61-66
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Konferensbidrag (refereegranskat)abstract
- In the Chinese postal system, letters are sorted manually using a sorting frame, consisting of vertical and horizontal arrays of pigeon-holes of different dimensions. Letter sorting is a time consuming and a mentally intensive task involving repetitive movements of shoulder and hand muscles. Musculoskeletal complaints and disorders of the lower back, shoulder and hand occur frequently among the letter sorting workers. A total of 293 letter-sorters (71 males and 222 females) from Beijing Postal Sorting Office were subjected to a general health check-up including musculoskeletal disorders coupled with administration of a questionnaire. The worker's daily work load was evaluated by counting the number of letters sorted in each pigeon-hole in the sorting frame and also by considering their arm movements and body postures. The workplace dimensions were also measured. Results revealed that 62.1% of the workers complained of low back pain, 78.5% of shoulder pain and 48.8% of hand pain. A high percentage of workers seemed to have mental intensive symptoms, such as, headache, dizziness and drowsiness. Almost 25% of the female wokers indicated irregularity in their menstruation. An improved ergonomic design of the sorting frame is recommended.
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