| 1. |
- Frauenfelder, H., et al.
(författare)
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A unified model of protein dynamics
- 2009
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:13, s. 5129-5134
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Tidskriftsartikel (refereegranskat)abstract
- Protein functions require conformational motions. We show here that the dominant conformational motions are slaved by the hydration shell and the bulk solvent. The protein contributes the structure necessary for function. We formulate a model that is based on experiments, insights from the physics of glass-forming liquids, and the concepts of a hierarchically organized energy landscape. To explore the effect of external fluctuations on protein dynamics, we measure the fluctuations in the bulk solvent and the hydration shell with broadband dielectric spectroscopy and compare them with internal fluctuations measured with the Mossbauer effect and neutron scattering. The result is clear. Large-scale protein motions are slaved to the fluctuations in the bulk solvent. They are controlled by the solvent viscosity, and are absent in a solid environment. Internal protein motions are slaved to the beta fluctuations of the hydration shell, are controlled by hydration, and are absent in a dehydrated protein. The model quantitatively predicts the rapid increase of the mean-square displacement above approximate to 200 K, shows that the external beta fluctuations determine the temperature- and time-dependence of the passage of carbon monoxide through myoglobin, and explains the nonexponential time dependence of the protein relaxation after photodissociation.
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| 2. |
- Grimheden, Martin, et al.
(författare)
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Culture coaching : A model for facilitating globally distributed collaborative work
- 2006
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Ingår i: 36th Annual Frontiers in Education, Conference Program, Vols 1-4. - NEW YORK, NY : IEEE. - 9781424402564 ; , s. 1669-1674
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Konferensbidrag (refereegranskat)abstract
- Engineering students engaged in product-based learning typically see what they have produced, but do not as easily see what they have learned. In a joint course between the Royal Institute of Technology in Stockholm, Sweden and Stanford University, U.S., graduate students from each university worked in high performance design-development teams on globally distributed scenarios for an industrial client. One of the difficulties of distributed teamwork is establishing team cohesion, trust, and credibility early in the project. Recognizing these challenges, an intervention engaging local "culture coaches" was implemented. Each coach served as a facilitator and interpreter of each team's similarities and differences with regards to local class culture as well as the social culture. In I he study, the work of the culture coaches contributed to a more unified team identity and increased student awareness of learning in the design process and product.
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| 3. |
- Saxena, Richa, et al.
(författare)
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
- 2007
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
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Tidskriftsartikel (refereegranskat)abstract
- New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
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| 4. |
- Undeland, Ingrid, 1968, et al.
(författare)
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Seafood and health-the full story
- 2009
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Ingår i: Marine Functional Foods. - 9789086860784
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Undeland, Ingrid, 1968, et al.
(författare)
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Seafood and health: What is the full story?
- 2009
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Ingår i: Marine Functional Food. - The Netherlands : Wageningen Academic Publishers. - 9789086860784 ; , s. 17-87
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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