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Amelioration of typ...
Amelioration of type 2 diabetes by the novel 6, 8-guanidyl luteolin quinone-chromium coordination via biochemical mechanisms and gut microbiota interaction
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- Ge, Xiaodong (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
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- He, Xiaoyu (författare)
- Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China.
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- Liu, Junwei (författare)
- Yancheng Inst Technol, Coll Marine & Bioengn, Yancheng 224051, Jiangsu, Peoples R China.
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- Zeng, Feng (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
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- Chen, Ligen (författare)
- Yancheng Inst Technol, Coll Marine & Bioengn, Yancheng 224051, Jiangsu, Peoples R China.
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- Xu, Wei (författare)
- Yancheng Inst Technol, Coll Marine & Bioengn, Yancheng 224051, Jiangsu, Peoples R China.
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- Shao, Rong (författare)
- Yancheng Inst Technol, Coll Marine & Bioengn, Yancheng 224051, Jiangsu, Peoples R China.
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- Huang, Ying (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.
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- Farag, Mohamed A. (författare)
- Cairo Univ, Coll Pharm, Pharmacognosy Dept, Cairo, Egypt.
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- Capanoglu, Esra (författare)
- Istanbul Tech Univ, Fac Chem & Met Engn, Dept Food Engn, TR-34469 Istanbul, Turkiye.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakognosi
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- Zhao, Chao (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.;Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Fujian, Peoples R China.
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- Liu, Bin (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China.;Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China.
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Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China Fujian Agr & Forestry Univ, Natl Engn Res Ctr JUNCAO Technol, Fuzhou 350002, Fujian, Peoples R China. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: JOURNAL OF ADVANCED RESEARCH. - : Elsevier. - 2090-1232 .- 2090-1224. ; 46, s. 173-188
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Luteolin is a plant-derived flavonoid that exhibits a broad range of pharmacological activ-ities. Studies on luteolin have mainly focused on its use for hyperlipidaemia prevention, whereas the capacity of the flavonoid to hinder hyperglycaemia development remains underexplored.Objectives: To probe the anti-hyperglycemic mechanism of 6,8-guanidyl luteolin quinone-chromium coordination (GLQ.Cr), and to assess its regulatory effect on intestinal microbiota in type 2 diabetes mel-litus (T2DM) mice.Methods: High-sucrose/high-fat diet-induced and intraperitoneal injection of streptozotocin was used to develop a T2DM model. Glycometabolism related indicators, histopathology, and gut microbiota compo-sition in caecum samples were evaluated, and RNA sequencing (RNA-seq) of liver samples was con-ducted. Faecal microbiota transplantation (FMT) was further used to verify the anti-hyperglycemic activity of intestinal microbiota.Results: The administration of GLQ.Cr alleviated hyperglycaemia symptoms by improving liver and pan-creatic functions and modulating gut microbe communities (Lactobacillus, Alistipes, Parabacteroides, Lachnoclostridium, and Desulfovibrio). RNA-seq analysis showed that GLQ.Cr mainly affected the peroxi-some proliferative activated receptor (PPAR) signalling pathway in order to regulate abnormal glucose metabolism. FMT significantly modulated the abundance of Lactobacillus, Alloprevotella, Alistipes, Bacteroides, Ruminiclostridium, Brevundimonas and Pseudomonas in the caecum to balance blood glucose levels and counteract T2DM mice inflammation.Conclusion: GLQ.Cr improved the abnormal glucose metabolism in T2DM mice by regulating the PPAR signalling pathway and modulating intestinal microbial composition. FMT can improve the intestinal microecology of the recipient and in turn ameliorate the symptoms of T2DM-induced hyperglycaemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Anti-hyperglycemic
- Luteolin
- Intestinal microbiota
- Faecal microbiota transplantation
- RNA-seq
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Ge, Xiaodong
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He, Xiaoyu
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Liu, Junwei
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Zeng, Feng
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Chen, Ligen
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Xu, Wei
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Shao, Rong
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Huang, Ying
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Farag, Mohamed A ...
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Capanoglu, Esra
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El-Seedi, Hesham
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Zhao, Chao
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Liu, Bin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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JOURNAL OF ADVAN ...
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Uppsala universitet