| 1. |
- Raval, Aparna, et al.
(författare)
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Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
- 2007
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Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 129:5, s. 879-890
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Tidskriftsartikel (refereegranskat)abstract
- The heritability of B cell chronic lymphocytic leukemia (CLL) is relatively high; however, no predisposing mutation has been convincingly identified. We show that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL. Epigenetic silencing of DAPK1 by promoter methylation occurs in almost all sporadic CLL cases. Furthermore, we defined a disease haplotype, which segregates with the CLL phenotype in a large family. DAPK1 expression of the CLL allele is downregulated by 75% in germline cells due to increased HOXB7 binding. In the blood cells from affected family members, promoter methylation results in additional loss of DAPK1 expression. Thus, reduced expression of DAPK1 can result from germline predisposition, as well as epigenetic or somatic events causing or contributing to the CLL phenotype.
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| 4. |
- Eusebio, Alexandre, et al.
(författare)
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Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease.
- 2008
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Ingår i: Experimental Neurology. - : Elsevier BV. - 0014-4886 .- 1090-2430. ; 209:1, s. 125-30
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Tidskriftsartikel (refereegranskat)abstract
- Excessive synchronization of basal ganglia neural activity at low frequencies is considered a hallmark of Parkinson's disease (PD). However, few studies have unambiguously linked this activity to movement impairment through direct stimulation of basal ganglia targets at low frequency. Furthermore, these studies have varied in their methodology and findings, so it remains unclear whether stimulation at any or all frequencies < or = 20 Hz impairs movement and if so, whether effects are identical across this broad frequency band. To address these issues, 18 PD patients chronically implanted with deep brain stimulation (DBS) electrodes in both subthalamic nuclei were stimulated bilaterally at 5, 10 and 20 Hz after overnight withdrawal of their medication and the effects of the DBS on a finger tapping task were compared to performance without DBS (0 Hz). Tapping rate decreased at 5 and 20 Hz compared to 0 Hz (by 11.8+/-4.9%, p=0.022 and 7.4+/-2.6%, p=0.009, respectively) on those sides with relatively preserved baseline task performance. Moreover, the coefficient of variation of tap intervals increased at 5 and 10 Hz compared to 0 Hz (by 70.4+/-35.8%, p=0.038 and 81.5+/-48.2%, p=0.043, respectively). These data suggest that the susceptibility of basal ganglia networks to the effects of excessive synchronization may be elevated across a broad low-frequency band in parkinsonian patients, although the nature of the consequent motor impairment may depend on the precise frequencies at which synchronization occurs.
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| 5. |
- Holmberg, Sture, et al.
(författare)
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Drug-resistant bacteria in hospital wards - the role of ventilation
- 2009
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Ingår i: 9th International Conference and Exhibition - Healthy Buildings 2009, HB 2009. ; , s. 596-
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Konferensbidrag (refereegranskat)abstract
- To limit the airborne spread of infectious agents (antibiotic-resistant bacteria) in hospital wards is an increasing world-wide concern. A multi-disciplinary Swedish research team is together with industry focusing on this problem. New knowledge is sought on how building ventilation services should be designed to minimize the risk of airborne infectious agents. In the literature there is strong and sufficient evidence to demonstrate the association between ventilation, air movements in buildings and the transmission/spread of diseases. There is, however, insufficient data to specify and quantify the minimum ventilation requirements in relation to the spread of infectious diseases via the airborne route. The latest developments in the advanced numerical simulation (CFD) methods offer new possibilities to follow the routes of airborne contaminants. Many ventilation parameters, including air flow rates, thermal and pressure conditions as well as the behavior of persons in the room are analyzed. The influence of both local air supply and local air exhaust has been analyzed and very promising results from this part of the work are presented. A bacterium spread from a patient confined to his bed was limited and for certain conditions almost eliminated. Ventilation and spatial parameter combinations to limit and prevent the spread of contaminants are mapped for different hospital wards. The risk of airborne transmission is modeled and discussed. Implementation in practice is sought via close collaboration with industry.
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| 6. |
- Reza, Bagger, et al.
(författare)
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RF LDMOS Power Amplifier Integrated Circuits for Cellular Wireless Base Station Applications
- 2006
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Konferensbidrag (refereegranskat)abstract
- Three broadband RF LDMOS Power Amplifier Integrated Circuits (PA ICs) for cellular base station applications have been developed in Si LDMOS IC technologies. They can be used for all typical modulation formats from 800 MHz to 2300 MHz, and power levels from 30 W to 50 W depending on application. GSM/EDGE PA IC achieved 35 dB gain and 30 W with 200 MHz bandwidth (22% bandwidth) at 900_MHz. CDMA2000 PA IC achieved 30 dB gain and 40 W with 300 MHz bandwidth (15% bandwidth) at 1900 MHz. TD-SCDMA/WCDMA PA IC achieved 27 dB gain and 50 W under TD-SCDMA signal and 40 W under WCDMA signal with 400 MHz bandwidth (20% bandwidth) at 2100 MHz. All three PA ICs have been characterized under all typical modulations formats and showed excellent linear power, efficiency, and bandwidth. The excellent performances of these three PA ICs, simplify power amplifier designs, enable a small footprint and help lower the cost of the modern base-station.
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| 7. |
- Tsai, Pei-I, et al.
(författare)
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Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.
- 2008
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Ingår i: Neural development. - : Springer Science and Business Media LLC. - 1749-8104. ; 3, s. 26-
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Focal adhesion kinase (FAK) functions in cell migration and signaling through activation of the mitogen-activated protein kinase (MAPK) signaling cascade. Neuronal function of FAK has been suggested to control axonal branching; however, the underlying mechanism in this process is not clear. RESULTS: We have generated mutants for the Drosophila FAK gene, Fak56. Null Fak56 mutants display overgrowth of larval neuromuscular junctions (NMJs). Localization of phospho-FAK and rescue experiments suggest that Fak56 is required in presynapses to restrict NMJ growth. Genetic analyses imply that FAK mediates the signaling pathway of the integrin alphaPS3betanu heterodimer and functions redundantly with Src. At NMJs, Fak56 downregulates ERK activity, as shown by diphospho-ERK accumulation in Fak56 mutants, and suppression of Fak56 mutant NMJ phenotypes by reducing ERK activity. CONCLUSION: We conclude that Fak56 is required to restrict NMJ growth during NMJ development. Fak56 mediates an extracellular signal through the integrin receptor. Unlike its conventional role in activating MAPK/ERK, Fak56 suppresses ERK activation in this process. These results suggest that Fak56 mediates a specific neuronal signaling pathway distinct from that in other cellular processes.
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