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- Arriagada, R., et al.
(författare)
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Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
- 2004
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Ingår i: N Engl J Med. ; 350:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: On the basis of a previous meta-analysis, the International Adjuvant Lung Cancer Trial was designed to evaluate the effect of cisplatin-based adjuvant chemotherapy on survival after complete resection of non-small-cell lung cancer. METHODS: We randomly assigned patients either to three or four cycles of cisplatin-based chemotherapy or to observation. Before randomization, each center determined the pathological stages to include, its policy for chemotherapy (the dose of cisplatin and the drug to be combined with cisplatin), and its postoperative radiotherapy policy. The main end point was overall survival. RESULTS: A total of 1867 patients underwent randomization; 36.5 percent had pathological stage I disease, 24.2 percent stage II, and 39.3 percent stage III. The drug allocated with cisplatin was etoposide in 56.5 percent of patients, vinorelbine in 26.8 percent, vinblastine in 11.0 percent, and vindesine in 5.8 percent. Of the 932 patients assigned to chemotherapy, 73.8 percent received at least 240 mg of cisplatin per square meter of body-surface area. The median duration of follow-up was 56 months. Patients assigned to chemotherapy had a significantly higher survival rate than those assigned to observation (44.5 percent vs. 40.4 percent at five years [469 deaths vs. 504]; hazard ratio for death, 0.86; 95 percent confidence interval, 0.76 to 0.98; P<0.03). Patients assigned to chemotherapy also had a significantly higher disease-free survival rate than those assigned to observation (39.4 percent vs. 34.3 percent at five years [518 events vs. 577]; hazard ratio, 0.83; 95 percent confidence interval, 0.74 to 0.94; P<0.003). There were no significant interactions with prespecified factors. Seven patients (0.8 percent) died of chemotherapy-induced toxic effects. CONCLUSIONS: Cisplatin-based adjuvant chemotherapy improves survival among patients with completely resected non-small-cell lung cancer.
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- Chugai, N. N., et al.
(författare)
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Circumstellar interaction of the type Ia supernova 2002ic
- 2004
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 355, s. 627-637
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Tidskriftsartikel (refereegranskat)abstract
- We propose a model to account for the bolometric light curve, the quasi-continuum and the CaII emission features of the peculiar type Ia supernova (SN) 2002ic, which exploded in a dense circumstellar envelope. The model suggests that the SN Ia had the maximum possible kinetic energy and that the ejecta expand in an approximately spherically symmetric (possibly clumpy) circumstellar environment. The CaII and the quasi-continuum are emitted by shocked SN ejecta that underwent deformation and fragmentation in the intershock layer. Modelling of the CaII triplet implies that the contribution of the OI 8446-Åline is about 25 per cent of the 8500-Åfeature on day 234, which permits us to recover the flux in the CaII 8579-Åtriplet from the flux of 8500-Åblend reported by Deng et al. We use the CaII doublet and triplet fluxes on day 234 to derive the electron temperature (~ 4400 K) in the CaII line-emitting zone and the ratio of the total area of dense fragments to the area of the shell, S/S0~ 102. We argue that CaII bands and the quasi-continuum originate from different zones of the shocked ejecta that reflect the abundance stratification of the supernova.
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- Sollerman, Jesper, et al.
(författare)
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Observations of the Crab Nebula and Its Pulsar in the Far-Ultraviolet and in the Optical
- 2000
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 537, s. 861-874
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Tidskriftsartikel (refereegranskat)abstract
- We present far-UV observations of the Crab Nebula and its pulsar made with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. Broad, blueshifted absorption arising in the nebula is seen in C IV λ1550, reaching a blueward velocity of ~2500 km s-1. This can be interpreted as evidence for a fast outer shell surrounding the Crab Nebula, and we adopt a spherically symmetric model to constrain the properties of such a shell. From the line profile we find that the density appears to decrease outward in the shell. A likely lower limit to the shell mass is ~0.3 Msolar with an accompanying kinetic energy of ~1.5×1049 ergs. A fast massive shell with 1051 ergs cannot be excluded but is less likely if the density profile is much steeper than ρ(R)~R-4 and the maximum velocity is <~6000 km s-1. The observations cover the region 1140-1720 Å, which is further into the ultraviolet than has previously been obtained for the pulsar. With the time-tag mode of the spectrograph we obtain the pulse profile in this spectral regime. The profile is similar to that previously obtained by us in the near-UV, although the primary peak is marginally narrower. Together with the near-UV data, and new optical data from the Nordic Optical Telescope, our spectrum of the Crab pulsar covers the entire region from 1140 to 9250 Å. Dereddening the spectrum with a standard extinction curve we achieve a flat spectrum for the reddening parameters E(B-V)=0.52, R=3.1. This dereddened spectrum of the Crab pulsar can be fitted by a power law with spectral index αν=0.11+/-0.04. The main uncertainty in determining the spectral index is the amount and characteristics of the interstellar reddening, and we have investigated the dependence of αν on E(B-V) and R. In the extended emission covered by our 25''×0.5" slit in the far-UV, we detect C IV λ1550 and He II λ1640 emission lines from the Crab Nebula. Several interstellar absorption lines are detected along the line of sight to the pulsar. The Lyα absorption indicates a column density of (3.0+/-0.5)×1021 cm-2 of neutral hydrogen, which agrees well with our estimate of E(B-V)=0.52 mag. Other lines show no evidence of severe depletion of metals in atomic gas. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc. under NASA contract NAS5-26555.
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