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Estimation of recur...
Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease : the updated SMART2 algorithm
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- Hageman, Steven H. J. (författare)
- Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
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- McKay, Ailsa J. (författare)
- Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
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- Ueda, Peter (författare)
- Karolinska Institutet
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- Gunn, Laura H. (författare)
- Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.;Univ North Carolina Charlotte, Dept Publ Hlth Sci, Charlotte, NC USA.;Univ North Carolina Charlotte, Sch Data Sci, Charlotte, NC USA
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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- Hagström, Emil (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Bhatt, Deepak L. (författare)
- Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA
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- Steg, Ph Gabriel (författare)
- Univ Paris, Hop Bichat, AP HP, INSERM Unite,French Alliance Cardiovasc Trials, F-1148 Paris, France
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- Lall, Kristi (författare)
- Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
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- Magi, Reedik (författare)
- Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
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- Gynnild, Mari Nordbo (författare)
- NTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Stroke, Clin Med, St Olavs Hosp, Trondheim, Norway
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- Ellekjaer, Hanne (författare)
- NTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Stroke, Clin Med, St Olavs Hosp, Trondheim, Norway
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- Saltvedt, Ingvild (författare)
- NTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Geriatr, Clin Med, St Olavs Hosp, Trondheim, Norway
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- Tunon, Jose (författare)
- Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Cardiol, Madrid, Spain.;CIBERCV, Madrid, Spain
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- Mahillo, Ignacio (författare)
- Fdn Jimenez Diaz, Dept Epidemiol, Madrid, Spain
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- Acena, Alvaro (författare)
- Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Cardiol, Madrid, Spain
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- Kaminski, Karol (författare)
- Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland
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- Chlabicz, Malgorzata (författare)
- Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.;Med Univ Bialystok, Dept Invas Cardiol, Bialystok, Poland
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- Sawicka, Emilia (författare)
- Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.;Med Univ Bialystok, Dept Cardiol, Bialystok, Poland
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- Tillman, Taavi (författare)
- UCL, Ctr Noncommunicable Dis, Inst Global Hlth, London, England
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- McEvoy, John W. (författare)
- Natl Inst Prevent & Cardiovasc Hlth, Galway, Ireland.;Natl Univ Ireland Galway, Galway Campus, Galway, Ireland
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- Di Angelantonio, Emanuele (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England
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- Graham, Ian (författare)
- Univ Dublin, Trinity Coll Dublin, Sch Med, Dublin, Ireland
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- De Bacquer, Dirk (författare)
- Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium
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- Ray, Kausik K. (författare)
- Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
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- Dorresteijn, Jannick A. N. (författare)
- Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
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- Visseren, Frank L. J. (författare)
- Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
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(creator_code:org_t)
- 2022-02-15
- 2022
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 43:18, s. 1715-1727
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and may help refine clinical management. To broaden generalizability across regions, we updated the existing tool (SMART2 risk score) and recalibrated it with regional incidence rates and assessed its performance in external populations.Methods and results Individuals with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysms were included from the Utrecht Cardiovascular Cohort-SMART cohort [n = 8355; 1706 ASCVD events during a median follow-up of 8.2 years (interquartile range 4.2-12.5)] to derive a 10-year risk prediction model for recurrent ASCVD events (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular mortality) using a Fine and Gray competing risk-adjusted model. The model was recalibrated to four regions across Europe, and to Asia (excluding Japan), Japan, Australia, North America, and Latin America using contemporary cohort data from each target region. External validation used data from seven cohorts [Clinical Practice Research Datalink, SWEDEHEART, the international REduction of Atherothrombosis for Continued Health (REACH) Registry, Estonian Biobank, Spanish Biomarkers in Acute Coronary Syndrome and Biomarkers in Acute Myocardial Infarction (BACS/BAMI), the Norwegian COgnitive Impairment After STroke, and Bialystok PLUS/Polaspire] and included 369 044 individuals with established ASCVD of whom 62 807 experienced an ASCVD event. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] in BACS/BAMI to 0.772 (95% CI 0.659-0.886) in REACH Europe high-risk region. The clinical utility of the model was demonstrated across a range of clinically relevant treatment thresholds for intensified treatment options.Conclusion The SMART2 risk score provides an updated, validated tool for the prediction of recurrent ASCVD events in patients with established ASCVD across European and non-European populations. The use of this tool could allow for a more personalized approach to secondary prevention based upon quantitative rather than qualitative estimates of residual risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Risk prediction
- Secondary prevention
- Established ASCVD
- Personalized treatment
- Residual risk
- Recurrent risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hageman, Steven ...
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McKay, Ailsa J.
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Ueda, Peter
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Gunn, Laura H.
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Jernberg, Tomas
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Hagström, Emil
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visa fler...
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Bhatt, Deepak L.
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Steg, Ph Gabriel
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Lall, Kristi
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Magi, Reedik
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Gynnild, Mari No ...
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Ellekjaer, Hanne
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Saltvedt, Ingvil ...
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Tunon, Jose
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Mahillo, Ignacio
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Acena, Alvaro
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Kaminski, Karol
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Chlabicz, Malgor ...
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Sawicka, Emilia
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Tillman, Taavi
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McEvoy, John W.
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Di Angelantonio, ...
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Graham, Ian
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De Bacquer, Dirk
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Ray, Kausik K.
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Dorresteijn, Jan ...
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Visseren, Frank ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
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Uppsala universitet
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Karolinska Institutet