| 1. |
- Ayreen, Zobia, et al.
(författare)
-
Perilous paradigm of graphene oxide and its derivatives in biomedical applications : Insight to immunocompatibility
- 2024
-
Ingår i: Biomedicine and Pharmacotherapy. - : Elsevier. - 0753-3322 .- 1950-6007. ; 176
-
Forskningsöversikt (refereegranskat)abstract
- With advancements in nanotechnology and innovative materials, Graphene Oxide nanoparticles (GONP) have attracted lots of attention among the diverse types of nanomaterials owing to their distinctive physicochemical characteristics. However, the usage at scientific and industrial level has also raised concern to their toxicological interaction with biological system. Understanding these interactions is crucial for developing guidelines and recommendations for applications of GONP in various sectors, like biomedicine and environmental technologies. This review offers crucial insights and an in-depth analysis to the biological processes associated with GONP immunotoxicity with multiple cell lines including human whole blood cultures, dendritic cells, macrophages, and multiple cancer cell lines. The complicated interactions between graphene oxide nanoparticles and the immune system, are highlighted in this work, which reveals a range of immunotoxic consequences like inflammation, immunosuppression, immunostimulation, hypersensitivity, autoimmunity, and cellular malfunction. Moreover, the immunotoxic effects are also highlighted with respect to in vivo models like mice and zebrafish, insighting GO Nanoparticles' cytotoxicity. The study provides invaluable review for researchers, policymakers, and industrialist to understand and exploit the beneficial applications of GONP with a controlled measure to human health and the environment.
|
|
| 2. |
- Verma, Suresh K., et al.
(författare)
-
The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling
- 2024
-
Ingår i: Biomedicine and Pharmacotherapy. - : Elsevier. - 0753-3322 .- 1950-6007. ; 171
-
Forskningsöversikt (refereegranskat)abstract
- The aggrandised advancement in utility of advanced day-to-day materials and nanomaterials has raised serious concern on their biocompatibility with human and other biotic members. In last few decades, understanding of toxicity of these materials has been given the centre stage of research using many in vitro and in vivo models. Zebrafish (Danio rerio), a freshwater fish and a member of the minnow family has garnered much attention due to its distinct features, which make it an important and frequently used animal model in various fields of embryology and toxicological studies. Given that fertilization and development of zebrafish eggs take place externally, they serve as an excellent model organism for studying early developmental stages. Moreover, zebrafish possess a comparable genetic composition to humans and share almost 70% of their genes with mammals. This particular model organism has become increasingly popular, especially for developmental research. Moreover, it serves as a link between in vitro studies and in vivo analysis in mammals. It is an appealing choice for vertebrate research, when employing high-throughput methods, due to their small size, swift development, and relatively affordable laboratory setup. This small vertebrate has enhanced comprehension of pathobiology and drug toxicity. This review emphasizes on the recent developments in toxicity screening and assays, and the new insights gained about the toxicity of drugs through these assays. Specifically, the cardio, neural, and, hepatic toxicology studies inferred by applications of nanoparticles have been highlighted.
|
|
| 3. |
- Bawankar, Nilesh, et al.
(författare)
-
IoT-enabled Water Monitoring in Smart Cities with Retrofit and Solar-based Energy Harvesting
- 2024
-
Ingår i: IEEE Access. - : IEEE. - 2169-3536. ; 12, s. 58222-58238
-
Tidskriftsartikel (refereegranskat)abstract
- Monitoring water flow helps to identify leaks and wastage, leading to better management of water resources and conservation of this precious resource. To address this challenge, there is a need for an efficient and sustainable water management system. This paper presents an Internet of Things (IoT) based solution that involves retrofitting existing analog water meters using readily available off-the-shelf electronic components. Real-time data collection and analysis are performed through edge computation, which locally processes water meter images captured by the camera and extracts water meter readings. These readings are transmitted to the cloud for storage and further analysis. Various strategies have been implemented to optimize supply-current usage, preserving charge-discharge cycles of solar-powered batteries even in adverse environmental conditions. To streamline the firmware update process for multiple connected devices, a broadcasting technique is employed, offering the benefits of reduced manual labor and time savings. To assess the reliability and performance of developed solution, field deployment is conducted over several months, enabling the characterization of water usage patterns across different locations. Integrating energy harvesting capabilities into system reduces maintenance costs and promotes eco-friendly energy practices. Overall, this solution offers an effective and comprehensive approach towards achieving efficient and sustainable water management.
|
|
