| 1. |
- Kharitonov, D. S., et al.
(författare)
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Corrosion of AD31 (AA6063) Alloy in Chloride-Containing Solutions
- 2018
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Ingår i: Protection of Metals and Physical Chemistry of Surfaces. - : MAIK NAUKA/INTERPERIODICA/SPRINGER. - 2070-2051. ; 54:2, s. 291-300
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Tidskriftsartikel (refereegranskat)abstract
- Corrosion of AD31 (AA6063) alloy in neutral 0.05 M NaCl solutions is investigated via scanningprobe microscopy, linear-sweep voltammetry, and electrochemical-impedance spectroscopy. Al−Fe−Si−Mg intermetallic particles are determined to prevail in the structure of alloy and act as local cathodes. Intermodulation electrostatic-force-microscopy imaging shows that their Volta potential differs by 570 mV from that of the host aluminum matrix, making the alloy prone to localized corrosion. We show that the corrosion of alloy in the studied electrolyte mainly develops locally and results in pitting, with charge transfer being the limiting stage of the process. A mechanism of corrosion of the AD31 (AA6063) alloy in neutral chloride-containing solutions is proposed.
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| 2. |
- Bibikova, E. V., et al.
(författare)
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The early crust of the Volgo-Uralian segment of the East European Craton: Isotope-geochronological zirconology of metasedimentary rocks of the Bolshecheremshanskaya Formation and their Sm-Nd model ages
- 2015
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Ingår i: Stratigraphy and Geological Correlation. - 0869-5938. ; 23:1, s. 1-23
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of isotope-geochronological study of metasedimentary rocks of the Bolshecheremshanskaya Formation of the Volgo-Uralian segment of the East European Craton carried out to identify their protoliths. 16 samples of high-alumina gneisses from well cores were studied using the Sm-Nd isotope method and T-Nd(DM) model ages. Accessory zircons were selected from rocks with the most ancient model ages (more 3.2 Ga) in three wells: Minnibaevskaya 20000, Novo-Elkhovskaya 20009, and Zai-Karatayskaya 12930 in South Tatarstan. The isotope U-Pb dating of 200 zircon grains was performed on a Cameca 1280 NORDSIM secondary ion mass spectrometer at the Natural History Museum (Stockholm, Sweden). The most applicable sites for analysis of zircon crystals were pre-selected based on cathodoluminescence images. The analytical results demonstrate the diversity of zircon groups in age from 3.8 to 2.6 Ga and together with geochemical features of metasedimentary rocks of the Bolshecheremshanskaya Formation suggest the heterogeneous composition and age of provenance areas under denudation. Occurrence of Eoarchean and Paleoarchean zircons in the clastic material of the protolith of the Bolshecheremshanskaya gneisses indicates the existence of Early Archean crustal terrains in Volgo-Uralia.
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| 3. |
- Claesson, J., et al.
(författare)
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Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome
- 2016
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Ingår i: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 60:6, s. 697-709
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Forskningsöversikt (refereegranskat)abstract
- Background: The objective of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI) task force on fluid and drug therapy in adults with acute respiratory distress syndrome (ARDS) was to provide clinically relevant, evidence-based treatment recommendations according to standards for trustworthy guidelines. Methods: The guideline was developed according to standards for trustworthy guidelines, including a systematic review of the literature and use of the GRADE methodology for assessment of the quality of evidence and for moving from evidence to recommendations. Results: A total of seven ARDS interventions were assessed. We suggest fluid restriction in patients with ARDS (weak recommendation, moderate quality evidence). Also, we suggest early use of neuromuscular blocking agents (NMBAs) in patients with severe ARDS (weak recommendation, moderate quality evidence). We recommend against the routine use of other drugs, including corticosteroids, beta2 agonists, statins, and inhaled nitric oxide (iNO) or prostanoids in adults with ARDS (strong recommendations: low-to high-quality evidence). These recommendations do not preclude the use of any drug or combination of drugs targeting underlying or co-existing disorders. Conclusion: This guideline emphasizes the paucity of evidence of benefit - and potential for harm - of common interventions in adults with ARDS and highlights the need for prudence when considering use of non-licensed interventions in this patient population.
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| 4. |
- Claesson, Nils
(författare)
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Spökmaskinen : Sju förändringar och förflyttningar – gestaltningsprocesser i animerad film
- 2017
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- The Ghost Machine is a practice-based research project that explores the process of embodiment in animated film. It describes the process of transfiguration from the artist’s/auteur’s point of view and not from an outside position. The dissertation follows the embodiment of a dramatic text, the Ghost Sonata by August Strindberg (1907), into an animated film. The starting point is my experience of the drama, at the age of thirteen, when staged by Ingmar Bergman at the Royal Dramatic Theatre. As a teenager, the world of the grown-ups seemed to be corrupt, twisted and ruled by violent power plays and economic sanctions, and this play confirmed my world view. Was I right, as a thirteen-year-old boy? What kind of world emerges in my version of the Ghost Sonata? In this thesis work, the films and the experimental research process meet the practice and art of writing. Using text, not as “theory” separated from “practice” but as a bodily art practice, creates a shifting border between the results and intentions of art and filmmaking, and the results of writing. At the same time a unity emerges where the results of the research process can be seen and experienced in the interaction between the texts and the artwork. The Ghost Machine is a totality where the text, films and artworks included in the project are equally important and must be seen as a unity. The Ghost Machine is a work journey where travelling, animated film practice, networking with colleagues and collecting data are mixed with experiments using methods from contemporary arts practice, performance, reenactment, appropriation and transfiguration, blended with traditional puppet animation in classic Czech style. In collaboration with actors, mime artists, puppet makers, musicians and a minimal film crew, century old stop-motion animation is combined with computer animation. The textual part of the work falls into two categories: life stories and work stories. The work stories traces the forming of an artwork in all aspects. The life stories are related to the subject of ghosts. Suddenly, dead friends and dear family members claimed their space. The understanding of the Ghost Sonata came to be a process of sorting out and following lines of memory using an inverted version of the Orpheus myth as a guide. Instead of never turning around, when walking the dead out of oblivion, I chose to look back, again and again, until I hit something and could not write anymore.
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| 5. |
- Corada, Monica, et al.
(författare)
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Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier
- 2019
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Ingår i: Circulation Research. - 0009-7330 .- 1524-4571. ; 124:4, s. 511-525
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: The microvasculature of the central nervous system includes the blood-brain barrier (BBB), which regulates the permeability to nutrients and restricts the passage of toxic agents and inflammatory cells. Canonical Wnt/β-catenin signaling is responsible for the early phases of brain vascularization and BBB differentiation. However, this signal declines after birth, and other signaling pathways able to maintain barrier integrity at postnatal stage are still unknown.Objective: Sox17 (SRY [sex-determining region Y]-box 17) constitutes a major downstream target of Wnt/β-catenin in endothelial cells and regulates arterial differentiation. In the present article, we asked whether Sox17 may act downstream of Wnt/β-catenin in inducing BBB differentiation and maintenance.Methods and Results: Using reporter mice and nuclear staining of Sox17 and β-catenin, we report that although β-catenin signaling declines after birth, Sox17 activation increases and remains high in the adult. Endothelial-specific inactivation of Sox17 leads to increase of permeability of the brain microcirculation. The severity of this effect depends on the degree of BBB maturation: it is strong in the embryo and progressively declines after birth. In search of Sox17 mechanism of action, RNA sequencing analysis of gene expression of brain endothelial cells has identified members of the Wnt/β-catenin signaling pathway as downstream targets of Sox17. Consistently, we found that Sox17 is a positive inducer of Wnt/β-catenin signaling, and it acts in concert with this pathway to induce and maintain BBB properties. In vivo, inhibition of the β-catenin destruction complex or expression of a degradation-resistant β-catenin mutant, prevent the increase in permeability and retina vascular malformations observed in the absence of Sox17.Conclusions: Our data highlight a novel role for Sox17 in the induction and maintenance of the BBB, and they underline the strict reciprocal tuning of this transcription factor and Wnt/β-catenin pathway. Modulation of Sox17 activity may be relevant to control BBB permeability in pathological conditions.
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| 6. |
- Edlund, Petra, et al.
(författare)
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The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus radiodurans phytochrome at 2.1 angstrom resolution. The structure was obtained by serial femtosecond X-ray crystallography from microcrystals at an X-ray free electron laser. We find overall good agreement compared to a crystal structure at 1.35 angstrom resolution derived from conventional crystallography at cryogenic temperatures, which we also report here. The thioether linkage between chromophore and protein is subject to positional ambiguity at the synchrotron, but is fully resolved with SFX. The study paves the way for time-resolved structural investigations of the phytochrome photocycle with time-resolved SFX.
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| 7. |
- Fedotova, A. A., et al.
(författare)
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New Data on the Paleoproterozoic Age of Metamorphism in the Yelabuga Deformation Zone of Volgo-Uralia, East European Craton
- 2019
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Ingår i: Doklady Earth Sciences. - 1028-334X. ; 488:1, s. 1123-1127
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Tidskriftsartikel (refereegranskat)abstract
- Abstract: This data on the age of metamorphism of rocks of the Yelabuga zone and the geochronological data on detrital zircon from paragneisses of the same zone are presented, and their correlation with the ages of rocks from the Middle Volga megablock is made. The rocks of the Yelabuga zone and Middle Volga megablock have similar geochemical characteristics and degrees of metamorphism, but demonstrate the following differences: Paleoproterozoic metamorphism was clearly expressed in the studied rocks of the Yelabuga zone, which contrasts to rocks of the Middle Volga megablock, where no metamorphism of this age is manifested. The study of the U–Pb isotopic system in external zones of zircon crystals from the Yelabuga deformation zone suggests that rocks underwent two stages of metamorphism, 1.99 and 1.95 Ga ago.
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| 8. |
- Fernandez-Alonso, R., et al.
(författare)
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p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGF beta signaling
- 2015
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Ingår i: Cell Death and Differentiation. - : Springer Science and Business Media LLC. - 1350-9047 .- 1476-5403. ; 22:8, s. 1287-
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Tidskriftsartikel (refereegranskat)abstract
- Vasculogenesis, the establishment of the vascular plexus and angiogenesis, branching of new vessels from the preexisting vasculature, involves coordinated endothelial differentiation, proliferation and migration. Disturbances in these coordinated processes may accompany diseases such as cancer. We hypothesized that the p53 family member p73, which regulates cell differentiation in several contexts, may be important in vascular development. We demonstrate that p73 deficiency perturbed vascular development in the mouse retina, decreasing vascular branching, density and stability. Furthermore, p73 deficiency could affect non endothelial cells (ECs) resulting in reduced in vivo proangiogenic milieu. Moreover, p73 functional inhibition, as well as p73 deficiency, hindered vessel sprouting, tubulogenesis and the assembly of vascular structures in mouse embryonic stem cell and induced pluripotent stem cell cultures. Therefore, p73 is necessary for EC biology and vasculogenesis and, in particular, that DNp73 regulates EC migration and tube formation capacity by regulation of expression of pro-angiogenic factors such as transforming growth factor-beta and vascular endothelial growth factors. DNp73 expression is upregulated in the tumor environment, resulting in enhanced angiogenic potential of B16-F10 melanoma cells. Our results demonstrate, by the first time, that differential p73-isoform regulation is necessary for physiological vasculogenesis and angiogenesis and DNp73 overexpression becomes a positive advantage for tumor progression due to its pro-angiogenic capacity.
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| 9. |
- Fredman, D., et al.
(författare)
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Experiences and outcome from the implementation of a national Swedish automated external defibrillator registry
- 2018
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Ingår i: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 130, s. 73-80
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early cardiopulmonary resuscitation (CPR) and defibrillation with an Automated External Defibrillator (AED) increase survival from out-of-hospital cardiac arrest (OHCA). Although international guidelines recommend the use of AED registries to increase AED use, little is known about implementation. The aim of this paper is to describe the development of a national AED registry, to analyse the coverage and barriers to register AEDs. Methods: The Swedish AED Registry (SAEDREG) was initiated in 2009 with the purpose of gathering the data of all public AEDs in Sweden. Data on all AEDs between 2013 and 2016 were included in the study. Additionally, data of non-registered AEDs was collected in one region using a survey to AED owners focusing on AED functionality. Results: The number of AEDs doubled between 2013–2016. A total of 6703 AEDs (30%) were removed due to unavailability of validation. At the end of 2016, AEDs were most frequently registered in offices and workplaces, 45% (n = 7241) followed by shops, 7% (n = 1200). In the Gotland region, 218 AEDs, 57% (n = 124) were registered in the SAEDREG. Of n = 94 Non-registered AED functionality was high, the main reason not to register was unawareness of the SAEDREG, 74.5%. Of those aware of the register but not having registered, 25% stated “hard to register” as cause. Conclusions: A national AED registry may gather information of AEDs on a national level. Although numbers have doubled between 2013–2016 in Sweden, a large proportion is still non-registered. More awareness of the registry and easier registration process is needed. General AED functionality seems high regardless of registered or non-registered AEDs. A key area for future research may be to use AED-registers to ascertain effectiveness of AED programs in terms of actual patient outcome.
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| 10. |
- Gertsovich, Irina, et al.
(författare)
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Automatic estimation of a scale resolution in forensic images
- 2018
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 283, s. 58-71
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Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a new method for an automatic detection of a resolution of a scale or a ruler with graduation marks in the shoeprint images. The method creates a vector of the correlations estimated from the co-occurrence matrices for every row in a shoeprint image. The scale resolution is estimated from maxima in Fourier spectrum of the correlations’ vectors. The proposed method is evaluated on over 500 images taken at crime scenes and in a forensics laboratory. The experimental results indicate the possibility of applying the proposed method to automatically estimate the scale resolution in forensic images. The automatic detection of a scale resolution could be used to automatically rescale a forensic image before the printing this image in “one-to-one” scale. Furthermore, the proposed method could be used to automatically rescale images to an equal scale thus allowing to compare the images digitally.
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