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3D blood-brain barr...
3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism
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- Adams, Yvonne (author)
- Univ Copenhagen, Denmark
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- Clausen, Anne Skovsbo (author)
- Copenhagen Univ Hosp, Denmark; Copenhagen Univ Hosp, Denmark
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Jensen, Peter Ostrup (author)
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- Lager, Malin (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden
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- Wilhelmsson, Peter (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden
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- Henningsson, Anna J., 1972- (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden
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- Lindgren, Per-Eric (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Natl Reference Lab Borrel, Div Clin Microbiol, Other Tick Borne Bacter, Lab Med, Reg Jonkoping Cty, Jonkoping, Sweden
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- Faurholt-Jepsen, Daniel (author)
- Copenhagen Univ Hosp, Denmark
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- Mens, Helene (author)
- Copenhagen Univ Hosp, Denmark
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- Kraiczy, Peter (author)
- Goethe Univ Frankfurt, Germany
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- Kragh, Kasper Norskov (author)
- Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
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- Bjarnsholt, Thomas (author)
- Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
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- Kjaer, Andreas (author)
- Copenhagen Univ Hosp, Denmark; Copenhagen Univ Hosp, Denmark
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- Lebech, Anne-Mette (author)
- Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark
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- Jensen, Anja R. (author)
- Univ Copenhagen, Denmark
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(creator_code:org_t)
- CELL PRESS, 2023
- 2023
- English.
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In: ISCIENCE. - : CELL PRESS. - 2589-0042. ; 26:1
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Lyme neuroborreliosis (LNB), a tick-borne infection caused by spirochetes within the Borrelia burgdorferi sensu lato (s.L.) complex, is among the most prevalent bacterial central nervous system (CNS) infections in Europe and the US. Here we have screened a panel of low- passage B. burgdorferi s.l. isolates using a novel, human-derived 3D blood-brain barrier (BBB)-organoid model. We show that human-derived BBB-organoids support the entry of Borrelia spirochetes, leading to swelling of the organoids and a loss of their structural integrity. The use of the BBB-organoid model highlights the organotropism between B. burgdorferi s.l. genospecies and their ability to cross the BBB contributing to CNS infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Adams, Yvonne
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Clausen, Anne Sk ...
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Jensen, Peter Os ...
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Lager, Malin
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Wilhelmsson, Pet ...
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Henningsson, Ann ...
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Lindgren, Per-Er ...
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Faurholt-Jepsen, ...
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Mens, Helene
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Kraiczy, Peter
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Kragh, Kasper No ...
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Bjarnsholt, Thom ...
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Kjaer, Andreas
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Lebech, Anne-Met ...
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Jensen, Anja R.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Linköping University