| 1. |
- Dgedge, M, et al.
(författare)
-
The burden of disease in Maputo city, Mozambique : registered and autopsied deaths in 1994
- 2001
-
Ingår i: Bulletin of the World Health Organization. - 0042-9686 .- 1564-0604. ; 79:6, s. 546-552
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To classify the causes of death in Maputo City, Mozambique, using the methods of the Global Burden of Disease study, in order to provide information for health policy-makers and to obtain a baseline for future studies in Maputo City and provincial capitals.Methods: Data were taken from the Maputo City death register and autopsy records for 1994.Findings: A total of 9011 deaths were recorded in the death register, representing a coverage of approximately86%. Of these, 8114 deaths (92%) were classified by cause. Communicable, maternal, perinatal, and nutritionaldisorders accounted for 5319 deaths; noncommunicable diseases for 1834; and injuries for 961. The 10 leadingcauses of registered deaths were perinatal disorders (1643 deaths); malaria (928); diarrhoeal diseases (814);tuberculosis (456); lower respiratory infections (416); road-traffic accidents (371); anaemia (269); cerebrovasculardiseases (269); homicide (188); and bacterial meningitis (178).Conclusions: Infectious diseases of all types, injuries, and cerebrovascular disease ranked as leading causes of death, according to both the autopsy records and the city death register. AIDS-related deaths were underreported.With HIV infection increasing rapidly, AIDS will add to the already high burden of infectious diseases and premature mortality in Maputo City. The results of the study indicate that cause of death is a useful outcome indicator for disease control programmes.
|
|
| 2. |
- Cobb, Christopher S., et al.
(författare)
-
Angiotensin I-converting enzyme-like activity in tissues from the Atlantic hagfish (Myxine glutinosa) and detection of immunoreactive plasma angiotensins
- 2004
-
Ingår i: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. - : Elsevier BV. - 1096-4959. ; 138,:4, s. 357-364
-
Tidskriftsartikel (refereegranskat)abstract
- Using a highly sensitive fluorimetric assay, significant levels of angiotensin I -converting enzyme-like activity (ACELA) were detected in a range of tissues (branchial heart, gill, kidney with associated vasculature and archinephric duct, liver, whole brain and gut) from the Atlantic hagfish (Myxine glutinosa). The highest ACELA occurred in heart and gill (1.8 and 1.5 nmol His–Leu min−1 mg protein−1, respectively). The mammalian angiotensin I-converting enzyme (ACE) inhibitor, captopril, at 10−5 M was a potent inhibitor of the ACELA found in all hagfish tissues. Radioimmunoassay showed that immunoreactive angiotensins (251.8±11.8 pM) were detectable in hagfish plasma. The validity of the assay for measurement of hagfish angiotensins was indicated by the parallelism of the angiotensin II standard curve against serially diluted hagfish plasma. Measurement of immunoreactive plasma angiotensins and detection of significant levels of ACELA in a wide range of tissues gives indirect evidence for the presence of a renin–angiotensin system in hagfishes, the earliest evolved group of craniates
|
|
| 3. |
|
|
| 4. |
|
|
