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| 2. |
- Pantazis, N, et al.
(författare)
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Determining the likely place of HIV acquisition for migrants in Europe combining subject-specific information and biomarkers data
- 2019
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Ingår i: Statistical methods in medical research. - : SAGE Publications. - 1477-0334 .- 0962-2802. ; 28:7, s. 1979-1997
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Tidskriftsartikel (refereegranskat)abstract
- In most HIV-positive individuals, infection time is only known to lie between the time an individual started being at risk for HIV and diagnosis time. However, a more accurate estimate of infection time is very important in certain cases. For example, one of the objectives of the Advancing Migrant Access to Health Services in Europe (aMASE) study was to determine if HIV-positive migrants, diagnosed in Europe, were infected pre- or post-migration. We propose a method to derive subject-specific estimates of unknown infection times using information from HIV biomarkers’ measurements, demographic, clinical, and behavioral data. We assume that CD4 cell count (CD4) and HIV-RNA viral load trends after HIV infection follow a bivariate linear mixed model. Using post-diagnosis CD4 and viral load measurements and applying the Bayes’ rule, we derived the posterior distribution of the HIV infection time, whereas the prior distribution was informed by AIDS status at diagnosis and behavioral data. Parameters of the CD4–viral load and time-to-AIDS models were estimated using data from a large study of individuals with known HIV infection times (CASCADE). Simulations showed substantial predictive ability (e.g. 84% of the infections were correctly classified as pre- or post-migration). Application to the aMASE study ( n = 2009) showed that 47% of African migrants and 67% to 72% of migrants from other regions were most likely infected post-migration. Applying a Bayesian method based on bivariate modeling of CD4 and viral load, and subject-specific information, we found that the majority of HIV-positive migrants in aMASE were most likely infected after their migration to Europe.
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| 3. |
- Jaworski, G., et al.
(författare)
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The New Neutron Multiplicity Filter NEDA and Its First Physics Campaign with AGATA
- 2019
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Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 50:3, s. 585-590
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Tidskriftsartikel (refereegranskat)abstract
- A new neutron multiplicity filter NEDA, after a decade of design, R&D and construction, was employed in its first physics campaign with the AGATA spectrometer. Properties and performance of the array are discussed.
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| 4. |
- Valiente-Dobon, J. J., et al.
(författare)
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NEDA-NEutron Detector Array
- 2019
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 927, s. 81-86
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Tidskriftsartikel (refereegranskat)abstract
- The NEutron Detector Array, NEDA, will form the next generation neutron detection system that has been designed to be operated in conjunction with gamma-ray arrays, such as the tracking-array AGATA, to aid nuclear spectroscopy studies. NEDA has been designed to be a versatile device, with high-detection efficiency, excellent neutron-gamma discrimination, and high rate capabilities. It will be employed in physics campaigns in order to maximise the scientific output, making use of the different stable and radioactive ion beams available in Europe. The first implementation of the neutron detector array NEDA with AGATA 1 pi was realised at GANIL. This manuscript reviews the various aspects of NEDA.
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| 5. |
- Testov, D., et al.
(författare)
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High Resolution γ-Ray Spectrometry Using Galileo Array
- 2019
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Ingår i: Eurasian Journal of Physics and Functional Materials. - : L.N. Gumilyov Eurasian National University. - 2522-9869. ; 3:1, s. 84-90
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Tidskriftsartikel (refereegranskat)abstract
- The GALILEO γ-ray spectrometer has been constructed at the Legnaro National Laboratory of INFN (LNL-INFN). It can be coupled to advanced ancillary devices which allows nuclear structure studies employing the variety of in-beam γ-ray spectroscopy methods. Such studies benefit from reactions induced by the intense stable beams delivered by the Tandem-ALPI-PIAVE accelerator complex and by the radioactive beams which will be provided by the SPES facility. In this paper we outline two experiments performed within the experimental campaign at GALILEO coupled to the EUCLIDES Si-ball and the Neutron Wall array. The first one was aimed at spectroscopic studies in A=31 mirror nuclei and the second one at measurements of lifetimes of excited states in nuclei in the vicinity of 100Sn.
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