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Träfflista för sökning "WFRF:(Compagno A.) srt2:(2005-2009)"

Sökning: WFRF:(Compagno A.) > (2005-2009)

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1.
  • Andersen, Gorm, et al. (författare)
  • Catabolism of pyrimidines in yeast: A tool to understand degradation of anticancer drugs
  • 2006
  • Ingår i: Nucleosides, Nucleotides & Nucleic Acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 25:9-11, s. 991-996
  • Tidskriftsartikel (refereegranskat)abstract
    • The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved in degradation of several chemotherapeutic drugs, such as 5-fluorouracil; it also is important in plants, unicellular eukaryotes, and bacteria for the degradation of pyrimidine-based biocides/antibiotics. During the last decade we have developed a yeast species, Saccharomyces kluyveri, as a model and tool to study the genes and enzymes of the pyrimidine catabolic pathway. In this report, we studied degradation of uracil and its putative degradation products in 38 yeasts and showed that this pathway was present in the ancient yeasts but was lost approximately 100 million years ago in the S. cerevisiae lineage.
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2.
  • Piskur, Jure, et al. (författare)
  • How did Saccharomyces evolve to become a good brewer?
  • 2006
  • Ingår i: Trends in Genetics. - : Elsevier BV. - 1362-4555 .- 0168-9525. ; 22:4, s. 183-186
  • Tidskriftsartikel (refereegranskat)abstract
    • Brewing and wine production are among the oldest technologies and their products are almost indispensable in our lives. The central biological agents of beer and wine fermentation are yeasts belonging to the genus Saccharomyces, which can accumulate ethanol. Recent advances in comparative genomics and bioinformatics have made it possible to elucidate when and why yeasts produce ethanol in high concentrations, and how this remarkable trait originated and developed during their evolutionary history. Two research groups have shed light on the origin of the genes encoding alcohol dehydrogenase and the process of ethanol accumulation in Saccharomyces cerevisiae.
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