| 1. |
- Jern, Patrick, et al.
(författare)
-
Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?
- 2012
-
Ingår i: Bju International. - 1464-4096. ; 110:11C
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES To investigate associations between single nucleotide polymorphisms (SNPs) linked to the oxytocin, To investigate these associations in a large, population-based sample. PATIENTS AND METHODS In all, 1517 male twins and non-twin brothers of twins aged 18-45 years (mean = 26.43; SD = 4.87) A Bayesian linear mixed-effects model, which appropriately controls for between subjects dependence, We corrected for multiple testing using a linkage disequilibrium correlation measure. RESULTS We found a heterozygote effect on one SNP in the oxytocin receptor gene (rs75775), so that individuals Several SNPs in the arginine vasopressin receptor genes had rare or very rare genotypes. This study CONCLUSIONS Our results regarding the oxytocin receptor polymorphisms support previous studies that indicate a Oxytocin receptor genes are, for example, unlikely suitable targets for pharmacogenetic intervention Rare variants in arginine vasopressin receptor genes may have significant effects on premature
|
|
| 2. |
- Johansson, A, et al.
(författare)
-
Alcohol and aggressive behavior in men-moderating effects of oxytocin receptor gene (OXTR) polymorphisms.
- 2012
-
Ingår i: Genes, brain, and behavior. - 1601-183X. ; 11:2, s. 214-221
-
Tidskriftsartikel (refereegranskat)abstract
- We explored if the disposition to react with aggression while alcohol intoxicated was moderated by polymorphic variants of the oxytocin receptor gene (OXTR). Twelve OXTR polymorphisms were genotyped in 116 Finnish men [aged 18-30, M = 22.7, standard deviation (SD) = 2.4] who were randomly assigned to an alcohol condition in which they received an alcohol dose of 0.7 g pure ethanol/kg body weight or a placebo condition. Aggressive behavior was measured using a laboratory paradigm in which it was operationalized as the level of aversive noise administered to a fictive opponent. No main effects of the polymorphisms on aggressive behavior were found after controlling for multiple testing. The interactive effects between alcohol and two of the OXTR polymorphisms (rs4564970 and rs1488467) on aggressive behavior were nominally significant and remained significant for the rs4564970 when controlled for multiple tests. To the best of our knowledge, this is the first experimental study suggesting interactive effects of specific genetic variants and alcohol on aggressive behavior in humans.
|
|
| 3. |
|
|
