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- Uy, G. L., et al.
(författare)
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Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation
- 2015
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Ingår i: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 50:12, s. 1513-1518
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Tidskriftsartikel (refereegranskat)abstract
- In patients with multiple myeloma (MM) undergoing autologous hematopoietic cell transplantation (auto-HCT), peripheral blood progenitor cells may be collected following mobilization with growth factor alone (GF) or cytotoxic chemotherapy plus GF (CC+GF). It is uncertain whether the method of mobilization affects post-transplant outcomes. We compared these mobilization strategies in a retrospective analysis of 968 patients with MM from the Center for International Blood and Marrow Transplant Research database who received an auto-Ha in the US and Canada between 2007 and 2012. The kinetics of neutrophil engraftment (>= 0.5 x 10(9)/L) was similar between groups (13 vs 13 days, P=0.69) while platelet engraftment (>= 20 x 10(9)/L) was slightly faster with CC+GF (19 vs 18 days, P=0.006). Adjusted 3-year PFS was 43% (95% confidence interval (CI) 38-48) in GF and 40% (95% CI 35-45) in CC+GF, P=0.33. Adjusted 3-year OS was 82% (95% CI 78-86) vs 80% (95% CI 75-84), P=0.43 and adjusted 5-year OS was 62% (95% CI 54-68) vs 60% (95% CI 52-67), P=0.76, for GF and CC+GF, respectively. We conclude that MM patients undergoing auto-Ha have similar outcomes irrespective of the method of mobilization and found no evidence that the addition of chemotherapy to mobilization contributes to disease control.
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- Colliston, W. P., et al.
(författare)
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Geochronological constraints on the Hartbees River Thrust and Augrabies Nappe: New insights into the assembly of the Mesoproterozoic Namaqua-Natal Province of Southern Africa
- 2015
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Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 265, s. 150-165
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Tidskriftsartikel (refereegranskat)abstract
- The region around Augrabies in the Namaqua sector provides insights into the processes that formed the Namaqua-Natal tectonic Province. Progressive ductile shear deformation during the long lasting Namaqua Orogeny was coeval with the global Grenvillian Orogeny. The Mesoproterozoic Namaqua-Natal Province is composed of severely deformed and metamorphosed rocks in terranes bounded by major thrust and shear zones. The interpreted research results deal with events around the Hartbees River Thrust, a suture zone where the granulite grade Grunau (Kakamas) terrane was overthrust onto the amphibolite grade Bladgrond (Bushmanland) terrane. The series of distinct deformation stages D-1-D-6 that have been identified during previous research in the western regions of the Namaqua sector, is also discernible in the study region around Augrabies. Microbeam geochronological techniques were used to date zircons from four samples of a granitic rock (the Karama'am Augen Gneiss) intrusive into the Hartbees River Thrust zone, and of a sample of granite (the Augrabies Granite) from the core of a large allochthonous sheath fold nappe in the Grunau terrane. The mean crystallisation age of the Karama'am intrusive is 1108 +/- 4 Ma and of the Augrabies Granite 1168 +/- 6 Ma. The sheath fold core of the latter granite is enclosed in the sheetlike Rooipad Granite (Riemvasmaak Granite) previously determined to be 1155 +/- 7 Ma. Crustal residence times deduced from Lu-Hf isotopic compositions of zircon cores and xenocrysts, cluster around 1710 Ma for the Augrabies Granite and about 200 Ma older for the Karama'am Granite Gneiss (with the oldest date at 2069 Ma). Collectively the available data enable reconstruction of the sequence of Namaqua Orogeny deformation stages: terrane assembly (D-1) at similar to 1195 Ma with metamorphism at 1191 +/- 12 Ma, pervasive folding and thrusting (D-2) at 1168 +/- 6 Ma, formation of major sheath and coaxial folds (D-3) at 1155 +/- 7 Ma, late open folds (D-4) at 1090 +/- 16 and a late metamorphism (coeval with major shear zones D-5-D-6?) at 1018 +/- 11 to 1024 +/- 14 Ma. (C) 2015 Elsevier B.V. All rights reserved.
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- Radivoyevitch, Tomas, et al.
(författare)
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Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma
- 2018
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Ingår i: Leukemia research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 74, s. 130-136
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Tidskriftsartikel (refereegranskat)abstract
- Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).Methods: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n=916), non-Hodgkin lymphoma (NHL; n=3546) and plasma cell myeloma (PCM; n=4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS.Results: 335 MDS/ AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR=4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR=2.5 [1.1, 2.5]); (2) >= 3 versus 1 line of chemotherapy for NHL (HR=1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005-2010 versus 1995-1999 (HR=2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/ MDS in HL, NHL and PCM to be 5-10 times the background rate. In contrast, relative risks were 10-50 for AML and approximately 100 for MDS in the autotransplant cohort.Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.
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| 7. |
- Tai, F, et al.
(författare)
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Abdominal Wall Miscellaneous
- 2015
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Ingår i: Hernia : the journal of hernias and abdominal wall surgery. - 1248-9204. ; 19 Suppl 1, s. S5-S12
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Tidskriftsartikel (refereegranskat)
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- Ahlström, Hanna, et al.
(författare)
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Governance, polycentricity and the global nitrogen and phosphorus cycles
- 2018
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Ingår i: Environmental Science and Policy. - : Elsevier BV. - 1462-9011 .- 1873-6416. ; 79, s. 54-65
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Tidskriftsartikel (refereegranskat)abstract
- Global change and governance scholars frequently highlight polycentricity as a feature of resilient governance, but both theoretical and empirical knowledge about features and outcomes of the concept are lacking at the global scale. Here we investigate the structural properties of governance of global nitrogen (N) and phosphorus (P) cycles, two processes in the 'planetary boundaries' framework. We have used a mixed-methods approach to institutional analysis, integrating polycentric theory with social network theory in environmental policy and legal studies. We include an actor collaboration case study, the Global Partnership on Nutrient Management (GPNM), to explore governance challenges associated with global N and P cycles. We set the scope for selection of relevant legal instruments using an overview of global N and P flows between Earth system 'components' (land, water, atmosphere, oceans, biosphere) and the major anthropogenic N and P perturbations. Our network analysis of citations of global N and P governance exposes the structural patterns of a loose network among the principal institutions and actors, in which legal instruments of the European Union serve as key cross-scale and cross-sectoral 'gateways'. We show that the current international regimes in place for regulating N- and P-related issues represent a gap in governance at the global level. In addition, we are able to show that the emergence of GPNM provides synergies in this context of insufficient governance. The GPNM can be viewed as a structure of polycentric governance as it involves deliberate attempts for mutual adjustments and self-organised action.
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- Athron, Peter, et al.
(författare)
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GAMBIT : the global and modular beyond-the-standard-model inference tool
- 2017
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
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Tidskriftsartikel (refereegranskat)abstract
- We describe the open-source global fitting package GAMBIT: the Global And Modular Beyond-the-Standard-Model Inference Tool. GAMBIT combines extensive calculations of observables and likelihoods in particle and astroparticle physics with a hierarchical model database, advanced tools for automatically building analyses of essentially any model, a flexible and powerful system for interfacing to external codes, a suite of different statistical methods and parameter scanning algorithms, and a host of other utilities designed to make scans faster, safer and more easily-extendible than in the past. Here we give a detailed description of the framework, its design and motivation, and the current models and other specific components presently implemented in GAMBIT. Accompanying papers deal with individual modules and present flrst GAMBIT results. GAMBIT can be downloaded from gambit.hepforge.org.
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| 10. |
- Athron, Peter, et al.
(författare)
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GAMBIT : the global and modular beyond-the-standard-model inference tool
- 2018
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Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:2
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Tidskriftsartikel (refereegranskat)abstract
- In Ref. (GAMBIT Collaboration: Athron et. al., Eur. Phys. J. C. arXiv: 1705.07908, 2017) we introduced the global-fitting framework GAMBIT. In this addendum, we describe a new minor version increment of this package. GAMBIT 1.1 includes full support for Mathematica backends, which we describe in some detail here. As an example, we backend SUSYHD (Vega and Villadoro, JHEP 07: 159, 2015), which calculates the mass of the Higgs boson in the MSSM from effective field theory. We also describe updated likelihoods in PrecisionBit and DarkBit, and updated decay data included in DecayBit.
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