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| 2. |
- Massie, Barry M, et al.
(författare)
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Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.
- 2010
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Ingår i: The New England journal of medicine. - 1533-4406. ; 363:15, s. 1419-28
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Tidskriftsartikel (refereegranskat)abstract
- Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We tested the hypothesis that the use of rolofylline, an adenosine A1-receptor antagonist, would improve dyspnea, reduce the risk of worsening renal function, and lead to a more favorable clinical course in patients with acute heart failure.
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| 3. |
- Lewis, Stephen R., et al.
(författare)
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Effect of humidity, temperature and railhead contamination on the performance of friction modifiers : Pin-on-disk study
- 2013
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Ingår i: Proceedings of the Institution of mechanical engineers. Part F, journal of rail and rapid transit. - : SAGE Publications. - 0954-4097 .- 2041-3017. ; 227:F2, s. 115-127
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Tidskriftsartikel (refereegranskat)abstract
- Commercially available friction modifiers are used in many different countries that have widely different atmospheric conditions. These variations in atmospheric conditions lead to varying levels of railhead oxidation and debris build-up. Friction modifiers can be applied to the rail without any prior cleaning of the rail and this can lead to varying friction modifier/iron oxide ratios potentially affecting the performance of the friction modifier. This paper reports the results of an investigation that was performed to determine the effects of varying atmospheric and oxide conditions on the performance of friction modifiers. A pin-on-disk test rig with an attached environmental chamber was used for the study. Results show that relative humidity has a pronounced effect on the way in which the friction modifier affects friction levels, and also the amount of time it remains on the disk. This also depends on the concentration of oxide in the friction modifier. Glow discharge optical emission spectroscopy analysis was also carried out to assess the effect of the friction modifier and atmospheric conditions on the chemical composition of the surface of the disk. Results show that the depth of surface modification is vastly different depending on the conditions and level of railhead debris.
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| 4. |
- Scuteri, Angelo, et al.
(författare)
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Arterial stiffness and influences of the metabolic syndrome: A cross-countries study.
- 2014
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Ingår i: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 233:2, s. 654-660
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Tidskriftsartikel (refereegranskat)abstract
- Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in ≥3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV).
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