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- Cox, Peter N., et al.
(författare)
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Fluorocarbons facilitate lung recruitment
- 2003
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Ingår i: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 29, s. 2297-2302
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Tidskriftsartikel (refereegranskat)abstract
- Objective: "Open the lung and keep it open" is increasingly accepted as a fundamental principle for mechanical ventilation. However, it is sometimes very difficult, or impossible, to recruit the diseased lung. We questioned whether one could facilitate recruitment by using a low dose of fluorocarbon in a model previously shown to be non-recruitable by conventional sustained inflation maneuvers. Design and setting: Experimental prospective study in a university laboratory. Animals and interventions: Nine saline-lavaged rabbits subjected to prolonged large tidal volume mechanical ventilation to establish significant lung injury were randomly allocated to two groups: control [High Frequency Oscillation (HFO) alone: n=4] or 1 ml/kg fluorocarbon (FC) treated (HFO/FC: n=5) for 2+1 h (experiment 1). An additional four similarly prepared animals were treated by single-lung instillation of 0.5 ml/kg dose of fluorocarbon and underwent serial computerized tomography scans at a series of predetermined step-wise pressure increase in both lungs (experiment 2). Measurements and results: In experiment 1 there was a very significant improvement in oxygenation in HFO/FC group (PaO2 increased from 108 mmHg to 424±81 mmHg; P<0.05) while there was no significant change in the control group. In experiment 2 lung volumes were determined using three-dimensional reconstruction. The lung having fluorocarbon showed a 2.4-fold increase in lung volume at inflation pressure of 15 cmH 2O compared to the lung without fluorocarbon. Conclusions: We propose that the low equilibrium surface tension and positive spreading coefficient of fluorocarbon facilitates lung recruitment by ungluing adherent surfaces in this model of lung injury.
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| 2. |
- Hedlund, Jonas, et al.
(författare)
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High-flux MFI membranes
- 2002
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Ingår i: Microporous and Mesoporous Materials. - 1387-1811 .- 1873-3093. ; 52:3, s. 179-189
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis and evaluation of high performance MFI-type membranes is described. These systems exhibit fluxes that are one to two orders of magnitude higher than previous literature reports, with comparable selectivities, when tested for various single component gases and for mixtures of C4, C6 and xylene isomers.These materials are the result of a rational fabrication approach targeting ultra-thin, defect-free MFI films on open supports by using a two-step support masking technique and a monolayer of colloidal nucleation seeds, followed by in situ hydrothermal growth, producing a defect-free film with a thickness of 0.5 μm. Reproducibility of the membrane preparation was excellent.
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