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Growth Hormone Impr...
Growth Hormone Improves Cognitive Function After Experimental Stroke
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Ong, L. K. (författare)
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Chow, W. Z. (författare)
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Tebay, C. (författare)
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Kluge, M. (författare)
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Pietrogrande, G. (författare)
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Zalewska, K. (författare)
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Crock, P. (författare)
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- Åberg, N David, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Bivard, A. (författare)
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Johnson, S. J. (författare)
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Walker, F. R. (författare)
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Nilsson, M. (författare)
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Isgaard, J. (författare)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2018
- 2018
- Engelska.
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Ingår i: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 49:5, s. 1257-1266
- Relaterad länk:
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https://www.ahajourn...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Purpose-Cognitive impairment is a common outcome for stroke survivors. Growth hormone (GH) could represent a potential therapeutic option as this peptide hormone has been shown to improve cognition in various clinical conditions. In this study, we evaluated the effects of peripheral administration of GH at 48 hours poststroke for 28 days on cognitive function and the underlying mechanisms. Methods-Experimental stroke was induced by photothrombotic occlusion in young adult mice. We assessed the associative memory cognitive domain using mouse touchscreen platform for paired-associate learning task. We also evaluated neural tissue loss, neurotrophic factors, and markers of neuroplasticity and cerebrovascular remodeling using biochemical and histology analyses. Results-Our results show that GH-treated stroked mice made a significant improvement on the paired-associate learning task relative to non-GH-treated mice at the end of the study. Furthermore, we observed reduction of neural tissue loss in GH-treated stroked mice. We identified that GH treatment resulted in significantly higher levels of neurotrophic factors (IGF-1 [insulin-like growth factor-1] and VEGF [vascular endothelial growth factor]) in both the circulatory and peri-infarct regions. GH treatment in stroked mice not only promoted protein levels and density of presynaptic marker (SYN-1 [synapsin-1]) and marker of myelination (MBP [myelin basic protein]) but also increased the density and area coverage of 2 major vasculature markers (CD31 and collagen-IV), within the peri-infarct region. Conclusions-These findings provide compelling preclinical evidence for the usage of GH as a potential therapeutic tool in the recovery phase of patients after stroke. Visual Overview-An online visual overview is available for this article.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- cognition
- growth hormone
- insulin-like growth factor-1
- neuronal plasticity
- stroke
- vascular
- traumatic brain-injury
- stress-induced disruption
- focal
- cerebral-ischemia
- photothrombotic stroke
- secondary neurodegeneration
- replacement therapy
- gh replacement
- mice
- performance
- poststroke
- Neurosciences & Neurology
- Cardiovascular System & Cardiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Stroke
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Till lärosätets databas
- Av författaren/redakt...
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Ong, L. K.
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Chow, W. Z.
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Tebay, C.
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Kluge, M.
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Pietrogrande, G.
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Zalewska, K.
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visa fler...
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Crock, P.
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Åberg, N David, ...
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Bivard, A.
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Johnson, S. J.
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Walker, F. R.
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Nilsson, M.
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Isgaard, J.
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visa färre...
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Göteborgs universitet