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| 2. |
- Chotiyarnwong, P., et al.
(författare)
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Is it time to consider population screening for fracture risk in postmenopausal women? A position paper from the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group
- 2022
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Ingår i: Archives of Osteoporosis. - : Springer Science and Business Media LLC. - 1862-3522 .- 1862-3514. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- A Summary The IOF Epidemiology and Quality of Life Working Group has reviewed the potential role of population screening for high hip fracture risk against well-established criteria. The report concludes that such an approach should strongly be considered in many health care systems to reduce the burden of hip fractures. Introduction The burden of long-term osteoporosis management falls on primary care in most healthcare systems. However, a wide and stable treatment gap exists in many such settings; most of which appears to be secondary to a lack of awareness of fracture risk. Screening is a public health measure for the purpose of identifying individuals who are likely to benefit from further investigations and/or treatment to reduce the risk of a disease or its complications. The purpose of this report was to review the evidence for a potential screening programme to identify postmenopausal women at increased risk of hip fracture. Methods The approach took well-established criteria for the development of a screening program, adapted by the UK National Screening Committee, and sought the opinion of 20 members of the International Osteoporosis Foundation's Working Group on Epidemiology and Quality of Life as to whether each criterion was met (yes, partial or no). For each criterion, the evidence base was then reviewed and summarized. Results and Conclusion The report concludes that evidence supports the proposal that screening for high fracture risk in primary care should strongly be considered for incorporation into many health care systems to reduce the burden of fractures, particularly hip fractures. The key remaining hurdles to overcome are engagement with primary care healthcare professionals, and the implementation of systems that facilitate and maintain the screening program.
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| 3. |
- Gomez, J. F., et al.
(författare)
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An SiO Toroid and Wide-angle Outflow Associated with the Massive Protostar W75N(B)-VLA2
- 2023
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Ingår i: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 956:2
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Tidskriftsartikel (refereegranskat)abstract
- We have carried out Atacama Large Millimeter/submillimeter Array observations of the massive star-forming region W75N(B), which contains the massive protostars VLA1, VLA2, and VLA3. Particularly, VLA2 is an enigmatic protostar associated with a wind-driven H2O maser shell, which has evolved from an almost isotropic outflow to a collimated one in just 20 yr. The shell expansion seemed to be halted by an obstacle located to the northeast of VLA2. Here we present our findings from observing the 1.3 mm continuum and H2CO and SiO emission lines. Within a region of ∼30″ (∼39,000 au) diameter, we have detected 40 compact millimeter continuum sources, three of them coinciding with VLA1, VLA2, and VLA3. While the H2CO emission is mainly distributed in a fragmented structure around the three massive protostars, but without any of the main H2CO clumps spatially coinciding with them, the SiO is highly concentrated on VLA2, indicating the presence of very strong shocks generated near this protostar. The SiO emission is clearly resolved into an elongated structure (∼0.″6 × 0.″3; ∼780 au×390 au) perpendicular to the major axis of the wind-driven maser shell. The structure and kinematics of the SiO emission are consistent with a toroid and a wide-angle outflow surrounding a central mass of ∼10 M ⊙, thus supporting previous theoretical predictions regarding the evolution of the outflow. Additionally, we have identified the expected location and estimated the gas density of the obstacle that is hindering the expansion of the maser shell.
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| 4. |
- Rodriguez-Kamenetzky, A., et al.
(författare)
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Characterizing the radio continuum nature of sources in the massive star-forming region W75N (B)
- 2020
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 496:3, s. 3128-3141
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Tidskriftsartikel (refereegranskat)abstract
- The massive star-forming region W75N (B) is thought to host a cluster of massive protostars (VLA 1, VLA 2, and VLA 3) undergoing different evolutionary stages. In this work, we present radio continuum data with the highest sensitivity and angular resolution obtained to date in this region, using the VLA-A and covering a wide range of frequencies (4-48 GHz), which allowed us to study the morphology and the nature of the emission of the different radio continuum sources. We also performed complementary studies with multi-epoch Very Large Array (VLA) data and Atacama Large Millimeter Array (ALMA) archive data at 1.3 mm wavelength. We find that VLA 1 is driving a thermal radio jet at scales of approximate to 0.1 arcsec (approximate to 130 au), but also shows signs of an incipient hypercompact HII region at scales of less than or similar to 1 arcsec (less than or similar to 1300 au). VLA 3 is also driving a thermal radio jet at scales of a few tenths of arcsec (few hundred of au). We conclude that this jet is shock exciting the radio continuum sources Bc and VLA 4 (obscured Herbig-Haro objects), which show proper motions moving outward from VLA 3 at velocities of approximate to 112-118 km s(-1). We have also detected three new weak radio continuum sources, two of them associated with millimetre continuum cores observed with ALMA, suggesting that these two sources are also embedded young stellar objects in this massive star-forming region.
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| 5. |
- Surcis, G., et al.
(författare)
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Monitoring of the polarized H 2 O maser emission around the massive protostars W75N(B)-VLA 1 and W75N(B)-VLA 2
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 673
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Tidskriftsartikel (refereegranskat)abstract
- Context. Several radio sources have been detected in the high-mass star-forming region W75N(B), with the massive young stellar objects VLA 1 and VLA 2 shown to be of particular interest among them. These objects are thought to be at different evolutionary stages: VLA 1 is in the early stage of photoionization and driving a thermal radio jet, while VLA 2 is a thermal, collimated ionized wind surrounded by a dusty disk or envelope. In both sources, 22 GHz H2O masers have been detected in the past. Those around VLA 1 show a persistent linear distribution along the thermal radio jet, while those around VLA 2 have traced the evolution from a non-collimated to a collimated outflow over a period of ~20 yr. The magnetic field inferred from the H2O masers has shown an orientation rotation following the direction of the major-axis of the shell around VLA 2, whereas it is immutable around VLA 1. Aims. By monitoring the polarized emission of the 22 GHz H2O masers around both VLA 1 and VLA 2 over a period of six years, we aim to determine whether the H2O maser distributions show any variation over time and whether the magnetic field behaves accordingly. Methods. The European VLBI Network was used in full polarization and phase-reference mode in order to determine the absolute positions of the 22 GHz H2O masers with a beam size of ~1 mas and to determine the orientation and the strength of the magnetic field. We observed four epochs separated by two years from 2014 to 2020. Results. We detected polarized emission from the H2O masers around both VLA 1 and VLA 2 in all the epochs. By comparing the H2O masers detected in the four epochs, we find that the masers around VLA 1 are tracing a nondissociative shock originating from the expansion of the thermal radio jet, while the masers around VLA 2 are tracing an asymmetric expansion of the gas that is halted in the northeast where the gas likely encounters a very dense medium. We also found that the magnetic field inferred from the H2O masers in each epoch can be considered as a portion of a quasi-static magnetic field estimated in that location rather than in that time. This allowed us to study the morphology of the magnetic field around both VLA 1 and VLA 2 locally across a larger area by considering the vectors estimated in all the epochs as a whole. We find that the magnetic field in VLA 1 is located along the jet axis, bending toward the north and south at the northeasterly and southwesterly ends of the jet, respectively, reconnecting with the large-scale magnetic field. The magnetic field in VLA 2 is perpendicular to the expansion directions until it encounters the denser matter in the northeast, where the magnetic field is parallel to the expansion direction and agrees with the large-scale magnetic field. We also measured the magnetic field strength along the line of sight in three of the four epochs, with resulting values of -764mG
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| 7. |
- Zhou, D, et al.
(författare)
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Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies
- 2023
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Ingår i: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 82:2, s. 235-245
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Tidskriftsartikel (refereegranskat)abstract
- Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle fibres, chronic weakness and fatigue. While complement-mediated destruction of capillary endothelia is implicated in paediatric and adult dermatomyositis, the complex diversity of complementC4in IIM pathology was unknown.MethodsWe elucidated the gene copy number (GCN) variations of totalC4,C4AandC4B, longandshort genesin 1644 Caucasian patients with IIM, plus 3526 matched healthy controls using real-time PCR or Southern blot analyses. Plasma complement levels were determined by single radial immunodiffusion.ResultsThe large study populations helped establish the distribution patterns of variousC4GCN groups. Low GCNs ofC4T(C4T=2+3) andC4Adeficiency (C4A=0+1) were strongly correlated with increased risk of IIM with OR equalled to 2.58 (2.28–2.91), p=5.0×10−53forC4T, and 2.82 (2.48–3.21), p=7.0×10−57forC4Adeficiency. Contingency and regression analyses showed that among patients withC4Adeficiency, the presence ofHLA-DR3became insignificant as a risk factor in IIM except for inclusion body myositis (IBM), by which 98.2% hadHLA-DR3with an OR of 11.02 (1.44–84.4). Intragroup analyses of patients with IIM for C4 protein levels and IIM-related autoantibodies showed that those with anti-Jo-1 or with anti-PM/Scl had significantly lower C4 plasma concentrations than those without these autoantibodies.ConclusionsC4Adeficiency is relevant in dermatomyositis,HLA-DRB1*03is important in IBM and bothC4Adeficiency andHLA-DRB1*03contribute interactively to risk of polymyositis.
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