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Highlights from the first year of Odin observations
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
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Tidskriftsartikel (refereegranskat)abstract
- Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
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| 2. |
- Dahlgren, Curt, et al.
(författare)
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Dödens semiotik : gravstenen som odödlighetens medium
- 2002
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Ingår i: Religion och sociologi : ett fruktbart möte : festskrift till Göran Gustafsson. - 0280-5723. ; , s. 97-110
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Allt fler gravstenar har enbart namn och födelsedata. Likaså minskar antalet gravar med yrkesangivelse. Antalet gravstenar med blommor, fåglar och naturscenerier ökar. Huruvida dessa skall ses som en beskrivning av individen är osäkert, men i vissa fall är det uppenbart, t ex när tecknet utgörs av en hund eller en tydlig yrkessymbol. Liksom i dödsannonserna kan man förvänta sig att också gravstenar kommer att ge antydningar om vem den döda var. På så sätt ökar chansen till odödlighet. Detta kan då antingen göras genom indicier eller genom ikoner, dvs. ett foto av den avlidna. Av de gravstenar som presenterats här kan enbart ett fåtal med säkerhet påstås vara ikoner eller indicier. Förmodligen kommer dessa att bli vanligare i framtiden. Så finns t ex två gravstenar på Västra kyrkogården i Halmstad där den ena har dels en färgbild av den avlidna svenska kvinnan, dels en flygande kolibri som suger nektar ur en blomma. Dessutom sitter en liten groda ovanpå naturstenen. Den andra stenen är rest över en invandrad och har dels en fjäril, dels ett kors, vilka båda är kristna tecken. Över korset finns ett fiskespö med en krokad fisk. Enligt min mening visar dessa tydligt på strävan efter odödlighet. Aven om jag kommer tillbaka om 20 år så vet jag hur kvinnan såg ut utan att någonsin ha träffat henne. Likaså vet jag att den invandrade mannen tyckte om att fiska, och kanske också var troende kristen.
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| 3. |
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| 4. |
- Lagerkvist, CI, et al.
(författare)
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A study of Cybele asteroids - I. Spin properties of ten asteroids
- 2001
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Ingår i: ICARUS. - : ACADEMIC PRESS INC. - 0019-1035. ; 149:1, s. 190-197
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Tidskriftsartikel (refereegranskat)abstract
- As a part of an observational program on Cybele asteroids we have obtained lightcurves of 10 of the larger asteroids. In this paper the results are presented for 229 Adelinda, 260 Huberta, 401 Ottilia 420 Bertholda, 466 Tisiphone, 522 Helga, 570 Kythera,
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| 6. |
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| 7. |
- Christophe, T, et al.
(författare)
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Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.
- 2002
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Ingår i: Scandinavian journal of immunology. - 0300-9475. ; 56:5, s. 470-6
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Tidskriftsartikel (refereegranskat)abstract
- Lipoxin A4 (LXA4) has been shown to bind to the leucocyte formyl peptide receptor (FPR) homologue, FPRL1, without triggering the biological activities induced by other FPRL1 agonists. We investigated the direct effect of LXA4 as well as the effect on agonist-induced biological responses using transfected HL-60 cells expressing FPR, FPRL1 or FPRL2. LXA4 neither induced an intracellular rise in calcium in these transfectants nor affected the response induced by the peptide Trp-Lys-Tyr-Met-Val-Met (WKYMVM), an agonist that activates cells through FPRL1 and -2. Both agonists induced Erk-2 activation; however, the eicosanoid-induced activity was independent of FPRL1 and FPRL2. Moreover, LXA4 was unable to trigger neutrophil upregulation of complement receptor 3 and respiratory burst, and it had no effect on the responses induced by triggering with WKYMVM. We conclude that LXA4 is unable to affect the WKYMVM-induced signalling through FPRL1 and suggest that it acts through a receptor different from FPRL1.
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| 8. |
- Christophe, T, et al.
(författare)
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The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
- 2001
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Ingår i: The Journal of biological chemistry. - 0021-9258. ; 276:24, s. 21585-93
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Tidskriftsartikel (refereegranskat)abstract
- Neutrophils express the G protein-coupled N-formyl peptide receptor (FPR) and its homologue FPRL1, whereas monocytes express FPR, FPRL1, and FPRL2, an orphan receptor sharing 83% amino acid identity with FPRL1. FPRL1 is a promiscuous receptor activated by serum amyloid A and by different synthetic peptides, including the hexapeptide Trp-Lys-Tyr-Met-Val-d-Met-NH(2) (WKYMVm). By measuring calcium flux in HL-60 cells transfected with FPR, FPRL1, or FPRL2, we show that WKYMVm activated all three receptors, whereas the l-conformer WKYMVM activated exclusively FPRL1 and FPRL2. The functionality of FPRL2 was further assessed by the ability of HL-60-FPRL2 cells to migrate toward nanomolar concentrations of hexapeptides. The half-maximal effective concentrations of WKYMVM for calcium mobilization in HL-60-FPRL1 and HL-60-FPRL2 cells were 2 and 80 nm, respectively. Those of WKYMVm were 75 pm and 3 nm. The tritiated peptide WK[3,5-(3)H(2)]YMVM bound to FPRL1 (K(D) approximately 160 nm), but not to FPR. The two conformers similarly inhibited binding of (125)I-labeled WKYMVm to FPRL2-expressing cells (IC(50) approximately 2.5-3 micrometer). Metabolic labeling with orthophosphoric acid revealed that FPRL1 was differentially phosphorylated upon addition of the l- or d-conformer, indicating that it induced different conformational changes. In contrast to FPRL1, FPRL2 was already phosphorylated in the absence of agonist and not evenly distributed in the plasma membrane of unstimulated cells. However, both receptors were internalized upon addition of either of the two conformers. Taken together, the results indicate that neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.
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| 9. |
- Dahlgren, Claes, 1949, et al.
(författare)
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The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor.
- 2000
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Ingår i: Blood. - 0006-4971. ; 95:5, s. 1810-8
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Tidskriftsartikel (refereegranskat)abstract
- A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis, mobilization of neutrophil complement receptor 3 (CR3), and activation of the neutrophil NADPH-oxidase. The fact that binding of fML[(3)H]F was inhibited by both fMLF and WKYMVm suggests that N-formyl peptide receptor (FPR) is shared by these peptides. However, the neutrophil response induced by the WKYMVm peptide was insensitive to the fMLF antagonists, cyclosporin H, and Boc-FLFLF that specifically block the function of the FPR. These results suggest that even though WKYMVm may bind FPR the cells are activated preferentially through a receptor distinct from the FPR. Using transfected HL-60 cells expressing either the FPR or its neutrophil homologue FPRL1, also referred to as LXA(4)R because it has been shown to bind lipoxin A(4), we show that WKYMVm is about 300-fold more active at mobilizing intracellular calcium through FPRL1 than through FPR. The WKYMVm activates FPRL1-expressing cells in a cyclosporin H-independent manner with an EC(50 )of around 75 pmol/L, whereas it activates FPR-expressing cells with an EC(50 )of around 25 nmol/L. The observation that exudated cells are primed in their response to WKYMVm suggests that FPRL1/LXA(4)R like FPR is stored in mobilizable organelles. (Blood. 2000;95:1810-1818)
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| 10. |
- Dahlgren, Thomas G., 1963, et al.
(författare)
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Molecular phylogeny of the model annelid Ophryotrocha
- 2001
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Ingår i: Biological Bulletin. - 0006-3185. ; 201:2, s. 193-203
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Tidskriftsartikel (refereegranskat)abstract
- Annelids of the genus Ophryotrocha are small opportunistic worms commonly found in polluted and nutrient-rich habitats such as harbors. Within this small group of about a, 40 described taxa a large variety of reproductive strategies are found, ranging from gonochoristic broadcast spawners to sequential hermaphroditic brooders. Many of the species have a short generation time and are easily maintained as laboratory cultures. Thus they have become a popular system for exploring a variety of biological questions including developmental genetics, ethology, and sexual selection. Despite considerable behavioral, reproductive, and karyological studies, a phylogenetic framework is lacking because most taxa are morphologically similar. In this study we use 16S mitochondrial gene sequence data to infer the phylogeny of Ophryotrocha strains commonly used in the laboratory. The resulting mtDNA topologies are generally well resolved and support a genetic split between hermaphroditic and gonochoristic species. Although the ancestral state could not be unambiguously identified, a change in reproductive strategy (i.e., hermaphroditism and gonochorism) occurred once within Ophryotrocha. Additionally, we show that sequential hermaphroditism evolved from a simultaneous hermaphroditic ancestor, and that characters previously used in phylogenetic reconstruction (i.e., jaw morphology and shape of egg mass) are homoplasic within the group.
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