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Impact of type of r...
Impact of type of reduced-intensity conditioning regimen on the outcomes of allogeneic haematopoietic cell transplantation in classical Hodgkin lymphoma
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- Ahmed, Sairah (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
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- Ghosh, Nilanjan (författare)
- Atrium Hlth, Levine Canc Inst, Hematol Oncol & Blood Disorders, Charlotte, NC USA.
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- Ahn, Kwang W. (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
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- Khanal, Manoj (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Litovich, Carlos (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.
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- Mussetti, Alberto (författare)
- Inst Catal Oncol Hosp, Hematol Dept, Barcelona, Spain.;Hosp Llobregat, IDIBELL Inst Catala Oncol, El Prat De Llobregat, Spain.
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- Chhabra, Saurabh (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- Cairo, Mitchell (författare)
- New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.
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- Mei, Matthew (författare)
- City Hope Natl Med Ctr, Duarte, CA USA.
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- William, Basem (författare)
- Ohio State Univ, Div Hematol, Columbus, OH 43210 USA.
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- Nathan, Sunita (författare)
- Rush Univ, Med Ctr, Chicago, IL 60612 USA.
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- Bejanyan, Nelli (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
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- Olsson, Richard (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
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- Dahi, Parastoo B. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA.
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- van der Poel, Marjolein (författare)
- Maastricht Univ, Med Ctr, Maastricht, Netherlands.
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- Steinberg, Amir (författare)
- Mt Sinai Hosp, Div Hematol & Oncol, New York, NY 10029 USA.
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- Kanakry, Jennifer (författare)
- NCI, NIH, Bethesda, MD 20892 USA.
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- Cerny, Jan (författare)
- Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.
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- Farooq, Umar (författare)
- Univ Iowa Hosp & Clin, Div Hematol, Oncol & Blood & Marrow Transplantat, Iowa City, IA 52242 USA.
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.
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- Kharfan-Dabaja, Mohamed A. (författare)
- Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL 32224 USA.
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- Sureda, Anna (författare)
- Univ Barcelona, Inst Catal Oncol Hosp, Hematol Dept, IDIBELL, Barcelona, Spain.
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- Fenske, Timothy S. (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- Hamadani, Mehdi (författare)
- Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Atrium Hlth, Levine Canc Inst, Hematol Oncol & Blood Disorders, Charlotte, NC USA. (creator_code:org_t)
- 2020-04-21
- 2020
- Engelska.
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Ingår i: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 190:4, s. 573-582
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Reduced-intensity conditioning (RIC) allogeneic haematopoietic cell transplantation (allo-HCT) is a curative option for select relapsed/refractory Hodgkin lymphoma (HL) patients; however, there are sparse data to support superiority of any particular conditioning regimen. We analyzed 492 adult patients undergoing human leucocyte antigen (HLA)-matched sibling or unrelated donor allo-HCT for HL between 2008 and 2016, utilizing RIC with either fludarabine/busulfan (Flu/Bu), fludarabine/melphalan (Flu/Mel140) or fludarabine/cyclophosphamide (Flu/Cy). Multivariable regression analysis was performed using a significance level of <0 center dot 01. There were no significant differences between regimens in risk for non-relapse mortality (NRM) (P = 0 center dot 54), relapse/progression (P = 0 center dot 02) or progression-free survival (PFS) (P = 0 center dot 14). Flu/Cy conditioning was associated with decreased risk of mortality in the first 11 months after allo-HCT (HR = 0 center dot 28; 95% CI = 0 center dot 10-0 center dot 73; P = 0 center dot 009), but beyond 11 months post allo-HCT it was associated with a significantly higher risk of mortality, (HR = 2 center dot 46; 95% CI = 0 center dot 1.32-4 center dot 61; P = 0 center dot 005). Four-year adjusted overall survival (OS) was similar across regimens at 62% for Flu/Bu, 59% for Flu/Mel140 and 55% for Flu/Cy (P = 0 center dot 64), respectively. These data confirm the choice of RIC for allo-HCT in HL does not influence risk of relapse, NRM or PFS. Although no OS benefit was seen between Flu/Bu and Flu/Mel 140; Flu/Cy was associated with a significantly higher risk of mortality beyond 11 months from allo-HCT (possibly due to late NRM events).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- reduced-intensity conditioning
- allogeneic hematopoietic cell transplant
- classical Hodgkin lymphoma
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Ahmed, Sairah
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Ghosh, Nilanjan
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Ahn, Kwang W.
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Khanal, Manoj
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Litovich, Carlos
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Mussetti, Albert ...
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visa fler...
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Chhabra, Saurabh
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Cairo, Mitchell
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Mei, Matthew
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William, Basem
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Nathan, Sunita
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Bejanyan, Nelli
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Olsson, Richard
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Dahi, Parastoo B ...
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van der Poel, Ma ...
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Steinberg, Amir
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Kanakry, Jennife ...
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Cerny, Jan
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Farooq, Umar
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Seo, Sachiko
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Kharfan-Dabaja, ...
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Sureda, Anna
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Fenske, Timothy ...
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Hamadani, Mehdi
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