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- Dahl, Sara, et al.
(författare)
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Can sense of coherence be a predictor for treatment outcome in patients with TMD-pain?
- 2011
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Ingår i: Svenska tandläkaresällskapets 47:e odontologisk riksstämma 2011. - : Svenska tandläkaresällskapet. ; , s. 110-110
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Aims. To investigate whether SOC (sense of coherence) changed after twelve months of treatment of TMD-pain, and if any such change could be correlated with treatment outcome. Another objective was to examine whether SOC was correlated with grade of depression and somatisation. Materials and Methods. 73 patients participated in the double-blind randomized controlled trial. The TMD-treatment was active for at least ten weeks and consisted of either a resilient or a non-occluding control appliance. Patients were diagnosed according to RDC/TMD and completed the SOC-29 at baseline and after twelve months. Treatment outcome was evaluated as a reduction of pain registered as characteristic pain intensity. No difference was found between the resilient appliance and the control appliance in reducing pain at the 12-months follow-up. Therefore the material was pooled together. Results. Of the 73 participating TMD-pain patients, a total of 44 patients filled in the SOC-29 at both baseline and after twelve months, and 42 of them also stated values for depression and somatisation. There was no correlation between high SOC and treatment outcome. No differences were found in the mean value of SOC for patients younger and older than 30 respectively 40 years. Significant correlations were found between mean differences of SOC and grade of depression, and between mean differences of grade of depression and somatisation. Conclusion. Our results showed that SOC was not a predictor for treatment outcome in TMD-pain patients previously treated with an appliance. SOC seems to be correlated to grade of depression.
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- Dahl, Åslög, 1955, et al.
(författare)
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Pollen, luftföroreningar och väderlek
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Pollenallergiker kan få ett bättre liv om de får information om tillståndet i luften. Det är till och med deras medborgerliga rättighet, enligt EU-direktiv, att få det. Därmed kan de förebygga symptom och planera sina aktiviteter. Avsikten med vår rapport är att bidra till underlaget för sådan en information, och att belysa hur de allergiska symptomen varierar med miljöfaktorer. Informationen bör innehålla en rapport om situationen innevarande dag. Vi ger ett förslag på hur den kan presenteras i form av ett luftkvalitetsindex. Dessutom bör informationen innehålla en prognos för de kommande dagarna. Pollenallergi, inklusive allergisk astma, är ett vanligt problem i vårt samhälle. Var fjärde till femte person är drabbad. Under sommarhalvåret bidrar allergin inte bara till att allergikerna får symptom från ögon och näsa, utan också till en totalt sett sänkt livskvalitet (Kiotseridis et al. 2013a, b). Ett flertal studier visar att luftföroreningar också påverkar luftvägarna. De kan orsaka en inflammation som kan förstärka allergiska besvär och som kan sänka tröskeln för att den skall uppstå. Våra resultat visar att ozon, kvävedioxid och partiklar bidrar till behovet av allergiläkemedel, när halterna överskrider ett visst tröskelvärde. Myndigheter med ansvar för miljö och folkhälsa på statlig, regional och kommunal nivå bör garantera att det finns förutsättningar för att förmedla informationen till allmänhet och sjukvård. Pollenövervakning saknas i flera regioner. I de fall sådan övervakning finns, är expertisen på området och nvändig infrastruktur inte långsiktigt tryggade. Verksamheten har hittills aldrig garanterats mer än ett år i taget. Detta innebär en ständig risk för bristande kontinuitet, att kompetens skall gå förlorad, och att underlaget till informationen är otillräcklig. I rapporten vill vi visa att allergibesvär beror av en kombination av faktorer, och bara kan förstås genom samarbete mellan experter från olika ämnesdiscipliner. Det är myndigheternas ås uppgift att tillhandahålla förutsättningar för att kompetens inom dessa områden kan samordnas. Föreliggande rapport är resultatet av ett regionalt utvecklingsprojekt i regi av länsstyrelserna i Västra Götaland och Skåne, inom ramen för Naturvårdsverkets programområde Hälsorelaterad Miljöpåverkan.
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- Fahnehjelm, Kristina, et al.
(författare)
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Optic nerve hypoplasia in children and adolescents; prevalence, ocular characteristics and behavioural problems
- 2014
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 92:6, s. 563-570
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To report prevalence, ocular characteristics and coexisting behavioural problems in children and adolescents with optic nerve hypoplasia (ONH), which is a common cause of visual impairment in children in western countries, often associated with neurological or endocrinological problems and where autism has been reported in severe cases with blindness. Methods: This is a population-based cross-sectional study of patients <20 years of age who had been diagnosed with ONH and lived in the county of Stockholm in December 2009. Ophthalmological assessments including fundus photographs with optic disc analyses were made. A questionnaire was used to screen for behaviour and development. Results: The prevalence of ONH in all living children <18 years of age in Stockholm was 17.3/100 000 with a prevalence of visual impairment (<0.3) of 3.9/100 000. In total, 66 patients, median age 9.3 years (0.6-19.4), 36 with bilateral and 30 with unilateral ONH, were included in the current study; 53 were re-examined clinically, group A, and 13 agreed to retrospective analyses of existing medical records, group B. Analyses of the optic discs were made in fundus photographs from 53 patients comparing a semi-automated (Retinal Size Tool) and a manual method (Zeki). There was a strong curvilinear correlation (rS = -0.91 p < 0.0001 for both eyes). Behavioural problems were more common (p < 0.05) in bilateral ONH. Conclusion: Opticnerve hypoplasia is a common ocular malformation with a prevalence of 17.3/100 000 children and adolescents <18 years of age in Stockholm. Unilateral ONH seems as common as bilateral.
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- Gabriková, Dana, et al.
(författare)
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Familiar Meniere's disease restricted to 1.48 Mb on chromosome 12p12.3 by allelic and haplotype association
- 2010
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Ingår i: Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1434-5161 .- 1435-232X. ; 55:12, s. 834-837
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Tidskriftsartikel (refereegranskat)abstract
- Meniere's disease (MD) is a disorder of the inner ear characterized by episodes of vertigo, tinnitus and fluctuating sensorineural hearing loss. Most MD cases are sporadic, but 5-15% of patients are familial following an autosomal dominant mode of inheritance with incomplete penetrance. We have previously identified a candidate gene region for MD on chromosome 12p12.3 using linkage analysis. We genotyped 15 Swedish families segregating familial MD (FMD) to further clarify the role of chromosome 12p in a larger cohort of families. Highly polymorphic marker loci were analyzed over the 16-Mb candidate region in affected and healthy family members as well as in control subjects. The results revealed allelic association between FMD and several individual polymorphic marker alleles and single-nucleotide polymorphisms. Moreover, a common three-marker haplotype spanning 1.48 Mb co-segregates with FMD in 60% of the families investigated, forming the core of a possible ancestral haplotype associated with FMD in Sweden.
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- Linderholm, Klas R, et al.
(författare)
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Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
- 2012
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Ingår i: Schizophrenia Bulletin. - : Oxford University Press. - 0586-7614 .- 1745-1701. ; 38:3, s. 426-432
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Tidskriftsartikel (refereegranskat)abstract
- Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
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